FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367060296> ?p ?o ?g. }

• W4367060296 abstract "Abstract Surgical resection remains a critical treatment option for many patients with primary and secondary hepatic neoplasms. Extended hepatectomy (eHx) may be required for some patients with large tumors, which may cause liver failure and individual death. Partial hepatectomy (pHx) and eHx mouse models were constructed, liver tissues were sampled at 18, 36, and 72 h post-hepatectomy, transcriptome and metabolome analyses were employed to find the differences in regeneration and injury between pHx and eHx. The results showed that eHx was associated with more severe liver injury and lower survival rates compared with pHx. Compared with the sham groups, transcriptomics data showed there were 1842, 2129, and 1277 differentially expressed genes (DEGs) in eHx and 962, 1305, and 732 DEGs in pHx at 18, 36, and 72 h post-hepatectomy, respectively. Compared with pHx, the number of DEGs reached a maximum of 230 at 18 h after surgery and decreased sequentially to 87 and 43 at 36 h and 72 h. Metabolomics analysis identified a total of 1399 metabolites, and 48 significant differentially produced metabolites (DPMs) were screened between eHx and pHx. Combined analysis of DEGs and DPMs indicated that cholesterol metabolism and insulin resistance may be two important pathways to liver regeneration and mouse survival post-extended hepatectomy. Our results showed the global influence of pHx and eHx on the transcriptome and metabolome in mouse liver, as both cholesterol metabolism and insulin resistance pathways were altered both at the transcriptional and metabolic levels between pHx and eHx groups." @default.
• W4367060296 created "2023-04-27" @default.
• W4367060296 creator A5006083516 @default.
• W4367060296 creator A5027725036 @default.
• W4367060296 creator A5033707375 @default.
• W4367060296 creator A5054691538 @default.
• W4367060296 creator A5063647013 @default.
• W4367060296 creator A5070703807 @default.
• W4367060296 creator A5074605992 @default.
• W4367060296 creator A5084587716 @default.
• W4367060296 creator A5085851862 @default.
• W4367060296 creator A5087276308 @default.
• W4367060296 creator A5089884329 @default.
• W4367060296 creator A5089895423 @default.
• W4367060296 date "2023-04-26" @default.
• W4367060296 modified "2023-10-16" @default.
• W4367060296 title "Transcriptome sequencing and metabolome analysis reveal metabolic reprogramming of partial hepatectomy and extended hepatectomy" @default.
• W4367060296 cites W1513453933 @default.
• W4367060296 cites W1965856483 @default.
• W4367060296 cites W1972126834 @default.
• W4367060296 cites W1991599908 @default.
• W4367060296 cites W1994270165 @default.
• W4367060296 cites W2002203425 @default.
• W4367060296 cites W2023465339 @default.
• W4367060296 cites W2056669979 @default.
• W4367060296 cites W2076981447 @default.
• W4367060296 cites W2095591310 @default.
• W4367060296 cites W2179438025 @default.
• W4367060296 cites W2346645906 @default.
• W4367060296 cites W2563604790 @default.
• W4367060296 cites W2611138580 @default.
• W4367060296 cites W2791712591 @default.
• W4367060296 cites W2791924652 @default.
• W4367060296 cites W2806559730 @default.
• W4367060296 cites W2897916903 @default.
• W4367060296 cites W2899043265 @default.
• W4367060296 cites W2906171798 @default.
• W4367060296 cites W2910969694 @default.
• W4367060296 cites W2946775532 @default.
• W4367060296 cites W2997782431 @default.
• W4367060296 cites W3001749946 @default.
• W4367060296 cites W3005072553 @default.
• W4367060296 cites W3017710116 @default.
• W4367060296 cites W3035458855 @default.
• W4367060296 cites W3047433286 @default.
• W4367060296 cites W3120773393 @default.
• W4367060296 cites W3172792725 @default.
• W4367060296 cites W3216889032 @default.
• W4367060296 cites W4211173486 @default.
• W4367060296 cites W4254164242 @default.
• W4367060296 cites W4281606738 @default.
• W4367060296 doi "https://doi.org/10.21203/rs.3.rs-2784866/v1" @default.
• W4367060296 hasPublicationYear "2023" @default.
• W4367060296 type Work @default.
• W4367060296 citedByCount "0" @default.
• W4367060296 crossrefType "posted-content" @default.
• W4367060296 hasAuthorship W4367060296A5006083516 @default.
• W4367060296 hasAuthorship W4367060296A5027725036 @default.
• W4367060296 hasAuthorship W4367060296A5033707375 @default.
• W4367060296 hasAuthorship W4367060296A5054691538 @default.
• W4367060296 hasAuthorship W4367060296A5063647013 @default.
• W4367060296 hasAuthorship W4367060296A5070703807 @default.
• W4367060296 hasAuthorship W4367060296A5074605992 @default.
• W4367060296 hasAuthorship W4367060296A5084587716 @default.
• W4367060296 hasAuthorship W4367060296A5085851862 @default.
• W4367060296 hasAuthorship W4367060296A5087276308 @default.
• W4367060296 hasAuthorship W4367060296A5089884329 @default.
• W4367060296 hasAuthorship W4367060296A5089895423 @default.
• W4367060296 hasBestOaLocation W43670602961 @default.
• W4367060296 hasConcept C104317684 @default.
• W4367060296 hasConcept C135870905 @default.
• W4367060296 hasConcept C141071460 @default.
• W4367060296 hasConcept C150194340 @default.
• W4367060296 hasConcept C159110652 @default.
• W4367060296 hasConcept C162317418 @default.
• W4367060296 hasConcept C16685009 @default.
• W4367060296 hasConcept C171056886 @default.
• W4367060296 hasConcept C21565614 @default.
• W4367060296 hasConcept C2776795407 @default.
• W4367060296 hasConcept C2776909242 @default.
• W4367060296 hasConcept C54355233 @default.
• W4367060296 hasConcept C55493867 @default.
• W4367060296 hasConcept C60644358 @default.
• W4367060296 hasConcept C71924100 @default.
• W4367060296 hasConcept C86803240 @default.
• W4367060296 hasConceptScore W4367060296C104317684 @default.
• W4367060296 hasConceptScore W4367060296C135870905 @default.
• W4367060296 hasConceptScore W4367060296C141071460 @default.
• W4367060296 hasConceptScore W4367060296C150194340 @default.
• W4367060296 hasConceptScore W4367060296C159110652 @default.
• W4367060296 hasConceptScore W4367060296C162317418 @default.
• W4367060296 hasConceptScore W4367060296C16685009 @default.
• W4367060296 hasConceptScore W4367060296C171056886 @default.
• W4367060296 hasConceptScore W4367060296C21565614 @default.
• W4367060296 hasConceptScore W4367060296C2776795407 @default.
• W4367060296 hasConceptScore W4367060296C2776909242 @default.
• W4367060296 hasConceptScore W4367060296C54355233 @default.
• W4367060296 hasConceptScore W4367060296C55493867 @default.
• W4367060296 hasConceptScore W4367060296C60644358 @default.
• W4367060296 hasConceptScore W4367060296C71924100 @default.

• next