Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367171823> ?p ?o ?g. }
- W4367171823 abstract "Abstract Background Polymyxin B is the first-line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data for its pharmacokinetic/pharmacodynamic (PK/PD) relationship are limited. This study aimed to investigate the relationship between polymyxin B exposure and efficacy for the treatment of CRO pneumonia in critically ill patients, and to optimize the individual dosing regimens. Methods Patients treated with polymyxin B for CRO pneumonia were enrolled. Blood samples were assayed using a validated high-performance liquid chromatography-tandem mass spectrometry method. Population PK analysis and Monte Carlo simulation were performed using Phoenix NLME software. Logistic regression analyses and receiver operating characteristic (ROC) curve were employed to identify the significant predictors and PK/PD indices of polymyxin B efficacy. Results A total of 105 patients were included, and the population PK model was developed based on 295 plasma concentrations. AUC ss,24 h /MIC (AOR = 0.97, 95% CI 0.95–0.99, p = 0.009), daily dose (AOR = 0.98, 95% CI 0.97–0.99, p = 0.028), and combination of inhaled polymyxin B (AOR = 0.32, 95% CI 0.11–0.94, p = 0.039) were independent risk factors for polymyxin B efficacy. ROC curve showed that AUC ss,24 h /MIC is the most predictive PK/PD index of polymyxin B for the treatment of nosocomial pneumonia caused by CRO, and the optimal cutoff point value was 66.9 in patients receiving combination therapy with another antimicrobial. Model-based simulation suggests that the maintaining daily dose of 75 and 100 mg Q12 h could achieve ≥ 90% PTA of this clinical target at MIC values ≤ 0.5 and 1 mg/L, respectively. For patients unable to achieve the target concentration by intravenous administration, adjunctive inhalation of polymyxin B would be beneficial. Conclusions For CRO pneumonia, daily dose of 75 and 100 mg Q12 h was recommended for clinical efficacy. Inhalation of polymyxin B is beneficial for patients who cannot achieve the target concentration by intravenous administration." @default.
- W4367171823 created "2023-04-28" @default.
- W4367171823 creator A5021737513 @default.
- W4367171823 creator A5035987284 @default.
- W4367171823 creator A5048237780 @default.
- W4367171823 creator A5060002817 @default.
- W4367171823 creator A5065452686 @default.
- W4367171823 creator A5069511766 @default.
- W4367171823 creator A5069579550 @default.
- W4367171823 creator A5083670512 @default.
- W4367171823 creator A5091076252 @default.
- W4367171823 date "2023-04-28" @default.
- W4367171823 modified "2023-10-17" @default.
- W4367171823 title "Optimization of polymyxin B regimens for the treatment of carbapenem-resistant organism nosocomial pneumonia: a real-world prospective study" @default.
- W4367171823 cites W1612376079 @default.
- W4367171823 cites W1804516907 @default.
- W4367171823 cites W1986647861 @default.
- W4367171823 cites W2010825345 @default.
- W4367171823 cites W2021909817 @default.
- W4367171823 cites W2068417232 @default.
- W4367171823 cites W2070752040 @default.
- W4367171823 cites W2106050397 @default.
- W4367171823 cites W2136635915 @default.
- W4367171823 cites W2139088282 @default.
- W4367171823 cites W2164032940 @default.
- W4367171823 cites W2168223549 @default.
- W4367171823 cites W2170001997 @default.
- W4367171823 cites W2178886985 @default.
- W4367171823 cites W2402789472 @default.
- W4367171823 cites W2473016454 @default.
- W4367171823 cites W2532347900 @default.
- W4367171823 cites W2605507933 @default.
- W4367171823 cites W2606797031 @default.
- W4367171823 cites W2609991153 @default.
- W4367171823 cites W2620438757 @default.
- W4367171823 cites W2765209236 @default.
- W4367171823 cites W2774590026 @default.
- W4367171823 cites W2781961936 @default.
- W4367171823 cites W2782523178 @default.
- W4367171823 cites W2786314763 @default.
- W4367171823 cites W2904470960 @default.
- W4367171823 cites W2911566892 @default.
- W4367171823 cites W2983277151 @default.
- W4367171823 cites W3011516456 @default.
- W4367171823 cites W3034104302 @default.
- W4367171823 cites W3034250799 @default.
- W4367171823 cites W3093388534 @default.
- W4367171823 cites W3111685685 @default.
- W4367171823 cites W3196041263 @default.
- W4367171823 cites W3216835035 @default.
- W4367171823 cites W4200250437 @default.
- W4367171823 cites W4290503168 @default.
- W4367171823 cites W4306694399 @default.
- W4367171823 doi "https://doi.org/10.1186/s13054-023-04448-z" @default.
- W4367171823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37106370" @default.
- W4367171823 hasPublicationYear "2023" @default.
- W4367171823 type Work @default.
- W4367171823 citedByCount "0" @default.
- W4367171823 crossrefType "journal-article" @default.
- W4367171823 hasAuthorship W4367171823A5021737513 @default.
- W4367171823 hasAuthorship W4367171823A5035987284 @default.
- W4367171823 hasAuthorship W4367171823A5048237780 @default.
- W4367171823 hasAuthorship W4367171823A5060002817 @default.
- W4367171823 hasAuthorship W4367171823A5065452686 @default.
- W4367171823 hasAuthorship W4367171823A5069511766 @default.
- W4367171823 hasAuthorship W4367171823A5069579550 @default.
- W4367171823 hasAuthorship W4367171823A5083670512 @default.
- W4367171823 hasAuthorship W4367171823A5091076252 @default.
- W4367171823 hasBestOaLocation W43671718231 @default.
- W4367171823 hasConcept C111113717 @default.
- W4367171823 hasConcept C112705442 @default.
- W4367171823 hasConcept C126322002 @default.
- W4367171823 hasConcept C2776685102 @default.
- W4367171823 hasConcept C2777288759 @default.
- W4367171823 hasConcept C2777914695 @default.
- W4367171823 hasConcept C2780026444 @default.
- W4367171823 hasConcept C2780675486 @default.
- W4367171823 hasConcept C2908647359 @default.
- W4367171823 hasConcept C501593827 @default.
- W4367171823 hasConcept C58471807 @default.
- W4367171823 hasConcept C71924100 @default.
- W4367171823 hasConcept C76318530 @default.
- W4367171823 hasConcept C86803240 @default.
- W4367171823 hasConcept C89423630 @default.
- W4367171823 hasConcept C99454951 @default.
- W4367171823 hasConceptScore W4367171823C111113717 @default.
- W4367171823 hasConceptScore W4367171823C112705442 @default.
- W4367171823 hasConceptScore W4367171823C126322002 @default.
- W4367171823 hasConceptScore W4367171823C2776685102 @default.
- W4367171823 hasConceptScore W4367171823C2777288759 @default.
- W4367171823 hasConceptScore W4367171823C2777914695 @default.
- W4367171823 hasConceptScore W4367171823C2780026444 @default.
- W4367171823 hasConceptScore W4367171823C2780675486 @default.
- W4367171823 hasConceptScore W4367171823C2908647359 @default.
- W4367171823 hasConceptScore W4367171823C501593827 @default.
- W4367171823 hasConceptScore W4367171823C58471807 @default.
- W4367171823 hasConceptScore W4367171823C71924100 @default.
- W4367171823 hasConceptScore W4367171823C76318530 @default.
- W4367171823 hasConceptScore W4367171823C86803240 @default.
- W4367171823 hasConceptScore W4367171823C89423630 @default.