FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367173638> ?p ?o ?g. }

• W4367173638 endingPage "1310" @default.
• W4367173638 startingPage "1298" @default.
• W4367173638 abstract "Abstract Although the landscape for treating acute myeloid leukemia (AML) patients has changed substantially in recent years, the majority of patients will eventually relapse and succumb to their disease. Allogeneic stem cell transplantation provides the best anti-AML treatment strategy, but is only suitable in a minority of patients. In contrast to B-cell neoplasias, chimeric antigen receptor (CAR) T-cell therapy in AML has encountered challenges in target antigen heterogeneity, safety, and T-cell dysfunction. We established a Fab-based adapter CAR (AdCAR) T-cell platform with flexibility of targeting and control of AdCAR T-cell activation. Utilizing AML cell lines and a long-term culture assay for primary AML cells, we were able to demonstrate AML-specific cytotoxicity using anti-CD33, anti-CD123, and anti-CLL1 adapter molecules in vitro and in vivo. Notably, we show for the first time the feasibility of sequential application of adapter molecules of different specificity in primary AML co-cultures. Importantly, using the AML platform, we were able to demonstrate that chronic T-cell stimulation and exhaustion can be counteracted through introduction of treatment-free intervals. As T-cell exhaustion and target antigen heterogeneity are well-known causes of resistance, the AdCAR platform might offer effective strategies to ameliorate these limitations." @default.
• W4367173638 created "2023-04-28" @default.
• W4367173638 creator A5003069482 @default.
• W4367173638 creator A5003705592 @default.
• W4367173638 creator A5006829356 @default.
• W4367173638 creator A5014818903 @default.
• W4367173638 creator A5015060661 @default.
• W4367173638 creator A5017273558 @default.
• W4367173638 creator A5031935199 @default.
• W4367173638 creator A5032183980 @default.
• W4367173638 creator A5033945848 @default.
• W4367173638 creator A5034688689 @default.
• W4367173638 creator A5037246404 @default.
• W4367173638 creator A5041376830 @default.
• W4367173638 creator A5045089174 @default.
• W4367173638 creator A5047324457 @default.
• W4367173638 creator A5047983915 @default.
• W4367173638 creator A5054978307 @default.
• W4367173638 creator A5057216216 @default.
• W4367173638 creator A5058141873 @default.
• W4367173638 creator A5065977507 @default.
• W4367173638 creator A5081503542 @default.
• W4367173638 creator A5082140749 @default.
• W4367173638 date "2023-04-27" @default.
• W4367173638 modified "2023-10-18" @default.
• W4367173638 title "Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML" @default.
• W4367173638 cites W1980594873 @default.
• W4367173638 cites W2020242768 @default.
• W4367173638 cites W2023101543 @default.
• W4367173638 cites W2065709542 @default.
• W4367173638 cites W2080750996 @default.
• W4367173638 cites W2514996992 @default.
• W4367173638 cites W2592935721 @default.
• W4367173638 cites W2610701591 @default.
• W4367173638 cites W2736799285 @default.
• W4367173638 cites W2761903029 @default.
• W4367173638 cites W2787301955 @default.
• W4367173638 cites W2787621143 @default.
• W4367173638 cites W2801641802 @default.
• W4367173638 cites W2811405063 @default.
• W4367173638 cites W2892758519 @default.
• W4367173638 cites W2898640974 @default.
• W4367173638 cites W2899030939 @default.
• W4367173638 cites W2906083502 @default.
• W4367173638 cites W2910803005 @default.
• W4367173638 cites W2913271650 @default.
• W4367173638 cites W2940767284 @default.
• W4367173638 cites W2952976647 @default.
• W4367173638 cites W2956092422 @default.
• W4367173638 cites W296750810 @default.
• W4367173638 cites W2982859960 @default.
• W4367173638 cites W2992738455 @default.
• W4367173638 cites W3003403042 @default.
• W4367173638 cites W3029593460 @default.
• W4367173638 cites W3132778321 @default.
• W4367173638 cites W3150736119 @default.
• W4367173638 cites W3157227887 @default.
• W4367173638 cites W3177405944 @default.
• W4367173638 cites W4205416963 @default.
• W4367173638 cites W4225404334 @default.
• W4367173638 cites W4226460098 @default.
• W4367173638 cites W4287578662 @default.
• W4367173638 doi "https://doi.org/10.1038/s41375-023-01905-0" @default.
• W4367173638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37106163" @default.
• W4367173638 hasPublicationYear "2023" @default.
• W4367173638 type Work @default.
• W4367173638 citedByCount "4" @default.
• W4367173638 countsByYear W43671736382023 @default.
• W4367173638 crossrefType "journal-article" @default.
• W4367173638 hasAuthorship W4367173638A5003069482 @default.
• W4367173638 hasAuthorship W4367173638A5003705592 @default.
• W4367173638 hasAuthorship W4367173638A5006829356 @default.
• W4367173638 hasAuthorship W4367173638A5014818903 @default.
• W4367173638 hasAuthorship W4367173638A5015060661 @default.
• W4367173638 hasAuthorship W4367173638A5017273558 @default.
• W4367173638 hasAuthorship W4367173638A5031935199 @default.
• W4367173638 hasAuthorship W4367173638A5032183980 @default.
• W4367173638 hasAuthorship W4367173638A5033945848 @default.
• W4367173638 hasAuthorship W4367173638A5034688689 @default.
• W4367173638 hasAuthorship W4367173638A5037246404 @default.
• W4367173638 hasAuthorship W4367173638A5041376830 @default.
• W4367173638 hasAuthorship W4367173638A5045089174 @default.
• W4367173638 hasAuthorship W4367173638A5047324457 @default.
• W4367173638 hasAuthorship W4367173638A5047983915 @default.
• W4367173638 hasAuthorship W4367173638A5054978307 @default.
• W4367173638 hasAuthorship W4367173638A5057216216 @default.
• W4367173638 hasAuthorship W4367173638A5058141873 @default.
• W4367173638 hasAuthorship W4367173638A5065977507 @default.
• W4367173638 hasAuthorship W4367173638A5081503542 @default.
• W4367173638 hasAuthorship W4367173638A5082140749 @default.
• W4367173638 hasBestOaLocation W43671736381 @default.
• W4367173638 hasConcept C10205521 @default.
• W4367173638 hasConcept C126322002 @default.
• W4367173638 hasConcept C147483822 @default.
• W4367173638 hasConcept C176290653 @default.
• W4367173638 hasConcept C203014093 @default.
• W4367173638 hasConcept C2776090121 @default.
• W4367173638 hasConcept C2777701055 @default.

• next