FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367173883> ?p ?o ?g. }

• W4367173883 endingPage "993" @default.
• W4367173883 startingPage "985" @default.
• W4367173883 abstract "Mutations in the ASXL transcriptional regulator 1 (ASXL1) and splicing factor 3b subunit 1(SF3B1) genes are commonly observed in myeloid neoplasms and are independent predicative factors for overall survival (OS). Only a few contradictory reports exist on the clinical significance of concurrent ASXL1 and SF3B1 mutations. Previous studies also did not exclude patients with mutations of other genes, which could be confounding factors.We identified 69 patients with mutation of only ASXL1, 89 patients with mutation of only SF3B1, and 17 patients with mutations exclusively of both ASXL1 and SF3B1 from our database of 8,285 patients and compared their clinical features and outcomes.Patients with ASXL1 mutations more frequently had acute myeloid leukemia (22.47%) or clonal cytopenia of unknown significance than patients with SF3B1 mutations (1.45%) or with ASXL1/SF3B1 mutations (11.76%). Patients with SF3B1 or ASXL1/SF3B1 mutations were more frequently diagnosed with myelodysplastic syndrome (75.36% and 64.71%, respectively) than patients with ASXL1 mutations (24.72%). Patients with ASXL1/SF3B1 (23.53%) mutations more frequently had myelodysplastic/myeloid proliferative neoplasm than did patients with ASXL1 mutations (5.62%) or with SF3B1 mutations (15.94%). OS of the ASXL1 mutation-only group was worse than that of the SF3B1 mutation-only group with a hazard ratio of 5.83 (p=0.017). Finally, and most importantly, the OS of the ASXL1/SF3B1 co-mutation group was poorer than that of both single-mutation groups (p=0.005).ASXL1/SF3B1 co-mutations portend worse OS than isolated ASXL1 or SF3B1 mutations, which might be due to abnormalities in both the epigenetic-regulatory and RNA-splicing pathways or because two genes instead of one are mutated." @default.
• W4367173883 created "2023-04-28" @default.
• W4367173883 creator A5000919987 @default.
• W4367173883 creator A5037567260 @default.
• W4367173883 creator A5047025874 @default.
• W4367173883 creator A5047282995 @default.
• W4367173883 creator A5070811797 @default.
• W4367173883 creator A5090794926 @default.
• W4367173883 date "2023-01-01" @default.
• W4367173883 modified "2023-10-16" @default.
• W4367173883 title "Co-mutation of<i>ASXL1</i>and<i>SF3B1</i>Predicts Poorer Overall Survival Than Isolated<i>ASXL1</i>or<i>SF3B1</i>Mutations" @default.
• W4367173883 cites W1486648620 @default.
• W4367173883 cites W1498250169 @default.
• W4367173883 cites W1889574318 @default.
• W4367173883 cites W1891790327 @default.
• W4367173883 cites W1969276101 @default.
• W4367173883 cites W1970390241 @default.
• W4367173883 cites W1972914723 @default.
• W4367173883 cites W1978972655 @default.
• W4367173883 cites W1985270900 @default.
• W4367173883 cites W1985823023 @default.
• W4367173883 cites W1993236149 @default.
• W4367173883 cites W1999813105 @default.
• W4367173883 cites W2014793178 @default.
• W4367173883 cites W2024401882 @default.
• W4367173883 cites W2026134786 @default.
• W4367173883 cites W2028803880 @default.
• W4367173883 cites W2036038124 @default.
• W4367173883 cites W2036318424 @default.
• W4367173883 cites W2045204068 @default.
• W4367173883 cites W2059497670 @default.
• W4367173883 cites W2063260586 @default.
• W4367173883 cites W2066040214 @default.
• W4367173883 cites W2073358532 @default.
• W4367173883 cites W2075017638 @default.
• W4367173883 cites W2090843125 @default.
• W4367173883 cites W2095340797 @default.
• W4367173883 cites W2104287429 @default.
• W4367173883 cites W2115400483 @default.
• W4367173883 cites W2123355582 @default.
• W4367173883 cites W2125482846 @default.
• W4367173883 cites W2126650761 @default.
• W4367173883 cites W2126816979 @default.
• W4367173883 cites W2135835093 @default.
• W4367173883 cites W2140352493 @default.
• W4367173883 cites W2140419897 @default.
• W4367173883 cites W2144878135 @default.
• W4367173883 cites W2144892629 @default.
• W4367173883 cites W2148933554 @default.
• W4367173883 cites W2149089431 @default.
• W4367173883 cites W2149858388 @default.
• W4367173883 cites W2159355068 @default.
• W4367173883 cites W2301134026 @default.
• W4367173883 cites W2326726820 @default.
• W4367173883 cites W2419140434 @default.
• W4367173883 cites W2608160060 @default.
• W4367173883 cites W2767788589 @default.
• W4367173883 cites W2770503151 @default.
• W4367173883 cites W2794277570 @default.
• W4367173883 cites W2820089296 @default.
• W4367173883 cites W2906235395 @default.
• W4367173883 cites W2928779381 @default.
• W4367173883 cites W2974725190 @default.
• W4367173883 cites W2983353988 @default.
• W4367173883 cites W2992415557 @default.
• W4367173883 cites W3006667406 @default.
• W4367173883 cites W3008933479 @default.
• W4367173883 cites W3013407285 @default.
• W4367173883 cites W3017704884 @default.
• W4367173883 cites W3097144642 @default.
• W4367173883 cites W3106538919 @default.
• W4367173883 cites W3119059375 @default.
• W4367173883 cites W3163866267 @default.
• W4367173883 cites W3208071358 @default.
• W4367173883 cites W3208512174 @default.
• W4367173883 cites W4226144246 @default.
• W4367173883 cites W4283271244 @default.
• W4367173883 cites W4283510917 @default.
• W4367173883 doi "https://doi.org/10.21873/invivo.13172" @default.
• W4367173883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37103105" @default.
• W4367173883 hasPublicationYear "2023" @default.
• W4367173883 type Work @default.
• W4367173883 citedByCount "0" @default.
• W4367173883 crossrefType "journal-article" @default.
• W4367173883 hasAuthorship W4367173883A5000919987 @default.
• W4367173883 hasAuthorship W4367173883A5037567260 @default.
• W4367173883 hasAuthorship W4367173883A5047025874 @default.
• W4367173883 hasAuthorship W4367173883A5047282995 @default.
• W4367173883 hasAuthorship W4367173883A5070811797 @default.
• W4367173883 hasAuthorship W4367173883A5090794926 @default.
• W4367173883 hasBestOaLocation W43671738831 @default.
• W4367173883 hasConcept C104317684 @default.
• W4367173883 hasConcept C126322002 @default.
• W4367173883 hasConcept C127716648 @default.
• W4367173883 hasConcept C207103383 @default.
• W4367173883 hasConcept C2778729363 @default.
• W4367173883 hasConcept C2779282312 @default.
• W4367173883 hasConcept C2780007613 @default.

• next