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• W4367173885 abstract "Background & objectives: During the COVID-19 pandemic, the death rate was reportedly 5-8 fold lower in India which is densely populated as compared to less populated western countries. The aim of this study was to investigate whether dietary habits were associated with the variations in COVID-19 severity and deaths between western and Indian population at the nutrigenomics level. Methods: In this study nutrigenomics approach was applied. Blood transcriptome of severe COVID-19 patients from three western countries (showing high fatality) and two datasets from Indian patients were used. Gene set enrichment analyses were performed for pathways, metabolites, nutrients, etc., and compared for western and Indian samples to identify the food- and nutrient-related factors, which may be associated with COVID-19 severity. Data on the daily consumption of twelve key food components across four countries were collected and a correlation between nutrigenomics analyses and per capita daily dietary intake was investigated. Results: Distinct dietary habits of Indians were observed, which may be associated with low death rate from COVID-19. Increased consumption of red meat, dairy products and processed foods by western populations may increase the severity and death rate by activating cytokine storm-related pathways, intussusceptive angiogenesis, hypercapnia and enhancing blood glucose levels due to high contents of sphingolipids, palmitic acid and byproducts such as CO2 and lipopolysaccharide (LPS). Palmitic acid also induces ACE2 expression and increases the infection rate. Coffee and alcohol that are highly consumed in western countries may increase the severity and death rates from COVID-19 by deregulating blood iron, zinc and triglyceride levels. The components of Indian diets maintain high iron and zinc concentrations in blood and rich fibre in their foods may prevent CO2 and LPS-mediated COVID-19 severity. Regular consumption of tea by Indians maintains high high-density lipoprotein (HDL) and low triglyceride in blood as catechins in tea act as natural atorvastatin. Importantly, regular consumption of turmeric in daily food by Indians maintains strong immunity and curcumin in turmeric may prevent pathways and mechanisms associated with SARS-CoV-2 infection and COVID-19 severity and lowered the death rate. Interpretation & conclusions: Our results suggest that Indian food components suppress cytokine storm and various other severity related pathways of COVID-19 and may have a role in lowering severity and death rates from COVID-19 in India as compared to western populations. However, large multi-centered case−control studies are required to support our current findings." @default.
• W4367173885 created "2023-04-28" @default.
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• W4367173885 date "2023-04-13" @default.
• W4367173885 modified "2023-10-18" @default.
• W4367173885 title "Indian food habit & food ingredients may have a role in lowering the severity & high death rate from COVID-19 in Indians" @default.
• W4367173885 cites W152529333 @default.
• W4367173885 cites W179582070 @default.
• W4367173885 cites W1839068802 @default.
• W4367173885 cites W1840097026 @default.
• W4367173885 cites W1908396164 @default.
• W4367173885 cites W1976420445 @default.
• W4367173885 cites W2026733815 @default.
• W4367173885 cites W2047438155 @default.
• W4367173885 cites W2052156346 @default.
• W4367173885 cites W2054468624 @default.
• W4367173885 cites W2070898850 @default.
• W4367173885 cites W2091246533 @default.
• W4367173885 cites W2103083685 @default.
• W4367173885 cites W2118634694 @default.
• W4367173885 cites W2124564580 @default.
• W4367173885 cites W2137526110 @default.
• W4367173885 cites W2137628898 @default.
• W4367173885 cites W2263668299 @default.
• W4367173885 cites W2293621304 @default.
• W4367173885 cites W2346740434 @default.
• W4367173885 cites W2346762587 @default.
• W4367173885 cites W2523962865 @default.
• W4367173885 cites W2529752507 @default.
• W4367173885 cites W2559463302 @default.
• W4367173885 cites W2579987911 @default.
• W4367173885 cites W2617950657 @default.
• W4367173885 cites W2743623537 @default.
• W4367173885 cites W2754425657 @default.
• W4367173885 cites W2883898864 @default.
• W4367173885 cites W2884775052 @default.
• W4367173885 cites W2900711967 @default.
• W4367173885 cites W2900949667 @default.
• W4367173885 cites W2949207671 @default.
• W4367173885 cites W2964783773 @default.
• W4367173885 cites W2981886926 @default.
• W4367173885 cites W3016981436 @default.
• W4367173885 cites W3030119977 @default.
• W4367173885 cites W3035729646 @default.
• W4367173885 cites W3036601227 @default.
• W4367173885 cites W3036681929 @default.
• W4367173885 cites W3042048038 @default.
• W4367173885 cites W3080135618 @default.
• W4367173885 cites W3083241614 @default.
• W4367173885 cites W3085936898 @default.
• W4367173885 cites W3086383783 @default.
• W4367173885 cites W3088607521 @default.
• W4367173885 cites W3091948906 @default.
• W4367173885 cites W3092069758 @default.
• W4367173885 cites W3093930665 @default.
• W4367173885 cites W3112656922 @default.
• W4367173885 cites W31282998 @default.
• W4367173885 cites W3130824414 @default.
• W4367173885 cites W3132906106 @default.
• W4367173885 cites W3145969289 @default.
• W4367173885 cites W3152358810 @default.
• W4367173885 cites W3157800650 @default.
• W4367173885 cites W3163743378 @default.
• W4367173885 cites W3166349787 @default.
• W4367173885 cites W3169250398 @default.
• W4367173885 cites W3170178772 @default.
• W4367173885 cites W3175780278 @default.
• W4367173885 cites W3177187816 @default.
• W4367173885 cites W3192948115 @default.
• W4367173885 cites W3198631436 @default.
• W4367173885 cites W3199868674 @default.
• W4367173885 cites W3205964128 @default.
• W4367173885 cites W3207328751 @default.
• W4367173885 cites W4210354992 @default.
• W4367173885 cites W4211203954 @default.
• W4367173885 cites W4220677498 @default.
• W4367173885 cites W4221098916 @default.
• W4367173885 cites W4221111336 @default.
• W4367173885 cites W4225247785 @default.
• W4367173885 cites W4226241041 @default.
• W4367173885 cites W4285743626 @default.
• W4367173885 doi "https://doi.org/10.4103/ijmr.ijmr_1701_22" @default.

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