FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367173889> ?p ?o ?g. }

• W4367173889 endingPage "13144" @default.
• W4367173889 startingPage "13135" @default.
• W4367173889 abstract "Abstract Background The recently developed severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mRNA vaccine has a short history of use and further information is needed regarding its efficacy, especially in immunocompromised conditions, such as plasma cell dyscrasia (PCD). Methods We retrospectively measured serum SARS‐CoV‐2 antibodies against the spike protein (S‐IgG) after the second and third mRNA vaccine doses (doses 2 and 3, respectively) in 109 patients with PCD. We evaluated the proportion of patients with an adequate humoral response (defined as S‐IgG titers ≥300 antibody units/mL). Results Although active anti‐myeloma treatments prior to vaccination had a significantly negative impact on adequate humoral response, specific drug subclasses including immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies were not negatively associated, except for B‐cell maturation antigen‐targeted therapy. Dose 3 (booster vaccination) led to significantly higher S‐IgG titers and more patients acquired an adequate humoral response. Furthermore, evaluation of vaccine‐induced cellular immune response in patients using T‐spot Discovery SARS‐CoV‐2 kit, revealed an enhanced cellular immune response after Dose 3. Conclusions This study highlighted the significance of booster SARS‐CoV‐2 mRNA vaccination in patients with PCD with respect to humoral and cellular immunity. Moreover, this study highlighted the potential impact of certain drug subclasses on vaccine‐induced humoral immune response." @default.
• W4367173889 created "2023-04-28" @default.
• W4367173889 creator A5006648909 @default.
• W4367173889 creator A5008005637 @default.
• W4367173889 creator A5012562620 @default.
• W4367173889 creator A5013530517 @default.
• W4367173889 creator A5017360616 @default.
• W4367173889 creator A5018501206 @default.
• W4367173889 creator A5039702055 @default.
• W4367173889 creator A5044499778 @default.
• W4367173889 creator A5048020501 @default.
• W4367173889 creator A5048802330 @default.
• W4367173889 creator A5050818051 @default.
• W4367173889 creator A5051558325 @default.
• W4367173889 creator A5052201218 @default.
• W4367173889 creator A5056315538 @default.
• W4367173889 creator A5064604064 @default.
• W4367173889 creator A5065236967 @default.
• W4367173889 creator A5078852881 @default.
• W4367173889 creator A5088405882 @default.
• W4367173889 creator A5088550519 @default.
• W4367173889 creator A5091786498 @default.
• W4367173889 creator A5091847960 @default.
• W4367173889 date "2023-04-26" @default.
• W4367173889 modified "2023-09-25" @default.
• W4367173889 title "Humoral and cellular immune response to second and third severe acute respiratory syndrome coronavirus 2 <scp>mRNA</scp> vaccine in patients with plasma cell dyscrasia" @default.
• W4367173889 cites W3045957828 @default.
• W4367173889 cites W3096044266 @default.
• W4367173889 cites W3096680486 @default.
• W4367173889 cites W3131241847 @default.
• W4367173889 cites W3131688063 @default.
• W4367173889 cites W3133936567 @default.
• W4367173889 cites W3135203780 @default.
• W4367173889 cites W3142337598 @default.
• W4367173889 cites W3153656426 @default.
• W4367173889 cites W3157453497 @default.
• W4367173889 cites W3162395942 @default.
• W4367173889 cites W3164553332 @default.
• W4367173889 cites W3173150656 @default.
• W4367173889 cites W3190398149 @default.
• W4367173889 cites W3205252781 @default.
• W4367173889 cites W3205344656 @default.
• W4367173889 cites W3205364181 @default.
• W4367173889 cites W3212220471 @default.
• W4367173889 cites W3214392375 @default.
• W4367173889 cites W4200105778 @default.
• W4367173889 cites W4205483821 @default.
• W4367173889 cites W4206451540 @default.
• W4367173889 cites W4210784896 @default.
• W4367173889 cites W4212798354 @default.
• W4367173889 cites W4213017933 @default.
• W4367173889 cites W4223508610 @default.
• W4367173889 cites W4225725936 @default.
• W4367173889 cites W4226023479 @default.
• W4367173889 cites W4226281116 @default.
• W4367173889 cites W4229050446 @default.
• W4367173889 cites W4282033105 @default.
• W4367173889 cites W4284993065 @default.
• W4367173889 cites W4289529788 @default.
• W4367173889 cites W4367173889 @default.
• W4367173889 doi "https://doi.org/10.1002/cam4.5996" @default.
• W4367173889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37102222" @default.
• W4367173889 hasPublicationYear "2023" @default.
• W4367173889 type Work @default.
• W4367173889 citedByCount "1" @default.
• W4367173889 countsByYear W43671738892023 @default.
• W4367173889 crossrefType "journal-article" @default.
• W4367173889 hasAuthorship W4367173889A5006648909 @default.
• W4367173889 hasAuthorship W4367173889A5008005637 @default.
• W4367173889 hasAuthorship W4367173889A5012562620 @default.
• W4367173889 hasAuthorship W4367173889A5013530517 @default.
• W4367173889 hasAuthorship W4367173889A5017360616 @default.
• W4367173889 hasAuthorship W4367173889A5018501206 @default.
• W4367173889 hasAuthorship W4367173889A5039702055 @default.
• W4367173889 hasAuthorship W4367173889A5044499778 @default.
• W4367173889 hasAuthorship W4367173889A5048020501 @default.
• W4367173889 hasAuthorship W4367173889A5048802330 @default.
• W4367173889 hasAuthorship W4367173889A5050818051 @default.
• W4367173889 hasAuthorship W4367173889A5051558325 @default.
• W4367173889 hasAuthorship W4367173889A5052201218 @default.
• W4367173889 hasAuthorship W4367173889A5056315538 @default.
• W4367173889 hasAuthorship W4367173889A5064604064 @default.
• W4367173889 hasAuthorship W4367173889A5065236967 @default.
• W4367173889 hasAuthorship W4367173889A5078852881 @default.
• W4367173889 hasAuthorship W4367173889A5088405882 @default.
• W4367173889 hasAuthorship W4367173889A5088550519 @default.
• W4367173889 hasAuthorship W4367173889A5091786498 @default.
• W4367173889 hasAuthorship W4367173889A5091847960 @default.
• W4367173889 hasBestOaLocation W43671738891 @default.
• W4367173889 hasConcept C147483822 @default.
• W4367173889 hasConcept C159047783 @default.
• W4367173889 hasConcept C159654299 @default.
• W4367173889 hasConcept C203014093 @default.
• W4367173889 hasConcept C22070199 @default.
• W4367173889 hasConcept C2776548049 @default.
• W4367173889 hasConcept C2777761686 @default.
• W4367173889 hasConcept C2777990475 @default.
• W4367173889 hasConcept C3017875465 @default.

• next