FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367174249> ?p ?o ?g. }

• W4367174249 endingPage "1245" @default.
• W4367174249 startingPage "1236" @default.
• W4367174249 abstract "Sepsis is a life-threatening biological condition that induces systemic tissue and organ dysfunction and confers a high mortality risk. Although the use of hydrocortisone in combination with ascorbic acid and thiamine (HAT therapy) significantly reduced mortality from sepsis or septic shock in a previous study, it did not improve mortality in subsequent randomized controlled trials (RCTs). Therefore, no definitive conclusion has been established on the benefits of HAT therapy for sepsis or septic shock. We performed a meta-analysis to assess the treatment outcomes of HAT therapy in patients with sepsis or septic shock.We searched databases (PubMed/MEDLINE, Embase, Scopus and Cochrane Library) for RCTs using the terms ascorbic acid, thiamine, sepsis, septic shock, and RCT. The primary outcome of this meta-analysis was the mortality rate, and the secondary outcomes were the incidence of new-onset acute renal injury (AKI), intensive care unit (ICU) length of stay (ICU-LOS), change in the Sequential Organ Failure Assessment (SOFA) score within 72 hours, and duration of vasopressor use.Nine RCTs were identified and included in the outcome evaluation. HAT therapy did not improve the 28-day and ICU mortality, new-onset AKI, ICU-LOS, or SOFA scores. However, HAT therapy significantly shortened the duration of vasopressor use.HAT therapy did not improve mortality, the SOFA score, renal injury, or ICU-LOS. Further studies are needed to confirm whether it shortens the duration of vasopressor use." @default.
• W4367174249 created "2023-04-28" @default.
• W4367174249 creator A5015711180 @default.
• W4367174249 creator A5022405845 @default.
• W4367174249 creator A5028403042 @default.
• W4367174249 creator A5029952836 @default.
• W4367174249 creator A5051870090 @default.
• W4367174249 creator A5061934624 @default.
• W4367174249 creator A5085372495 @default.
• W4367174249 date "2023-01-01" @default.
• W4367174249 modified "2023-09-27" @default.
• W4367174249 title "Efficacy of Ascorbic Acid, Thiamine, and Hydrocortisone Combination Therapy: Meta-analysis of Randomized Controlled Trials" @default.
• W4367174249 cites W1551891264 @default.
• W4367174249 cites W1965209096 @default.
• W4367174249 cites W1971900098 @default.
• W4367174249 cites W2007130516 @default.
• W4367174249 cites W2012342520 @default.
• W4367174249 cites W2065217249 @default.
• W4367174249 cites W2103861359 @default.
• W4367174249 cites W2142927411 @default.
• W4367174249 cites W2143999430 @default.
• W4367174249 cites W2144589352 @default.
• W4367174249 cites W2152465977 @default.
• W4367174249 cites W2398023930 @default.
• W4367174249 cites W2560240742 @default.
• W4367174249 cites W2769196701 @default.
• W4367174249 cites W2773432284 @default.
• W4367174249 cites W2801360758 @default.
• W4367174249 cites W2808829764 @default.
• W4367174249 cites W2884987392 @default.
• W4367174249 cites W2977803759 @default.
• W4367174249 cites W3000652395 @default.
• W4367174249 cites W3003172270 @default.
• W4367174249 cites W3011612860 @default.
• W4367174249 cites W3025274738 @default.
• W4367174249 cites W3069087306 @default.
• W4367174249 cites W3082376696 @default.
• W4367174249 cites W3129701391 @default.
• W4367174249 cites W3163521587 @default.
• W4367174249 cites W3188923037 @default.
• W4367174249 cites W3211482156 @default.
• W4367174249 cites W4200494889 @default.
• W4367174249 cites W4225747403 @default.
• W4367174249 doi "https://doi.org/10.21873/invivo.13200" @default.
• W4367174249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37103081" @default.
• W4367174249 hasPublicationYear "2023" @default.
• W4367174249 type Work @default.
• W4367174249 citedByCount "1" @default.
• W4367174249 countsByYear W43671742492023 @default.
• W4367174249 crossrefType "journal-article" @default.
• W4367174249 hasAuthorship W4367174249A5015711180 @default.
• W4367174249 hasAuthorship W4367174249A5022405845 @default.
• W4367174249 hasAuthorship W4367174249A5028403042 @default.
• W4367174249 hasAuthorship W4367174249A5029952836 @default.
• W4367174249 hasAuthorship W4367174249A5051870090 @default.
• W4367174249 hasAuthorship W4367174249A5061934624 @default.
• W4367174249 hasAuthorship W4367174249A5085372495 @default.
• W4367174249 hasBestOaLocation W43671742491 @default.
• W4367174249 hasConcept C126322002 @default.
• W4367174249 hasConcept C168563851 @default.
• W4367174249 hasConcept C177713679 @default.
• W4367174249 hasConcept C179755657 @default.
• W4367174249 hasConcept C185592680 @default.
• W4367174249 hasConcept C2776376669 @default.
• W4367174249 hasConcept C2776478404 @default.
• W4367174249 hasConcept C2777465075 @default.
• W4367174249 hasConcept C2777628635 @default.
• W4367174249 hasConcept C2778384902 @default.
• W4367174249 hasConcept C2778426790 @default.
• W4367174249 hasConcept C2779541074 @default.
• W4367174249 hasConcept C2780472472 @default.
• W4367174249 hasConcept C2986274086 @default.
• W4367174249 hasConcept C31903555 @default.
• W4367174249 hasConcept C71924100 @default.
• W4367174249 hasConceptScore W4367174249C126322002 @default.
• W4367174249 hasConceptScore W4367174249C168563851 @default.
• W4367174249 hasConceptScore W4367174249C177713679 @default.
• W4367174249 hasConceptScore W4367174249C179755657 @default.
• W4367174249 hasConceptScore W4367174249C185592680 @default.
• W4367174249 hasConceptScore W4367174249C2776376669 @default.
• W4367174249 hasConceptScore W4367174249C2776478404 @default.
• W4367174249 hasConceptScore W4367174249C2777465075 @default.
• W4367174249 hasConceptScore W4367174249C2777628635 @default.
• W4367174249 hasConceptScore W4367174249C2778384902 @default.
• W4367174249 hasConceptScore W4367174249C2778426790 @default.
• W4367174249 hasConceptScore W4367174249C2779541074 @default.
• W4367174249 hasConceptScore W4367174249C2780472472 @default.
• W4367174249 hasConceptScore W4367174249C2986274086 @default.
• W4367174249 hasConceptScore W4367174249C31903555 @default.
• W4367174249 hasConceptScore W4367174249C71924100 @default.
• W4367174249 hasIssue "3" @default.
• W4367174249 hasLocation W43671742491 @default.
• W4367174249 hasLocation W43671742492 @default.
• W4367174249 hasLocation W43671742493 @default.
• W4367174249 hasOpenAccess W4367174249 @default.
• W4367174249 hasPrimaryLocation W43671742491 @default.
• W4367174249 hasRelatedWork W2142349448 @default.
• W4367174249 hasRelatedWork W2617679349 @default.

• next