Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367175044> ?p ?o ?g. }
- W4367175044 endingPage "710" @default.
- W4367175044 startingPage "699" @default.
- W4367175044 abstract "Immunoglobulin A nephropathy (IgAN) is characterized by mesangial deposition of immune complexes containing galactose-deficient IgA1 (Gd-IgA1). This Gd-IgA1 is believed to originate from mucosally sited B cells, which are abundant in the Peyer's patches-rich distal ileum. Nefecon is a targeted-release form of budesonide developed to act in the distal ileum, thereby exerting a direct action on the mucosal tissue implicated in the pathogenesis of the disease.This review discusses IgAN pathophysiology and provides an overview of the current therapeutic landscape, focusing on Nefecon, the first drug to receive accelerated US approval and conditional EU approval for the treatment of patients with IgAN at risk of rapid disease progression.Nefecon trial data thus far have demonstrated a promising efficacy profile, with a predictable pattern of adverse events. Treatment with Nefecon for 9 months reduces proteinuria substantially (Part A of the Phase 3 trial and the Phase 2b trial). A nearly complete prevention of deterioration of renal function has been observed at 12 months in patients at greatest risk of rapid disease progression. Long-term data from Part B of the Phase 3 study will provide 24-month data, furthering understanding of the durability of the 9-month treatment course." @default.
- W4367175044 created "2023-04-28" @default.
- W4367175044 creator A5013453825 @default.
- W4367175044 creator A5042356850 @default.
- W4367175044 creator A5055078486 @default.
- W4367175044 creator A5067563722 @default.
- W4367175044 date "2023-05-16" @default.
- W4367175044 modified "2023-10-14" @default.
- W4367175044 title "Budesonide delayed-release capsules to reduce proteinuria in adults with primary immunoglobulin A nephropathy" @default.
- W4367175044 cites W1997948783 @default.
- W4367175044 cites W2015776989 @default.
- W4367175044 cites W2022316910 @default.
- W4367175044 cites W2030173510 @default.
- W4367175044 cites W2032354231 @default.
- W4367175044 cites W2036001773 @default.
- W4367175044 cites W2044471513 @default.
- W4367175044 cites W2050638474 @default.
- W4367175044 cites W2055585414 @default.
- W4367175044 cites W2057856705 @default.
- W4367175044 cites W2101794801 @default.
- W4367175044 cites W2113470371 @default.
- W4367175044 cites W2116730178 @default.
- W4367175044 cites W2123917517 @default.
- W4367175044 cites W2129111988 @default.
- W4367175044 cites W2133473614 @default.
- W4367175044 cites W2135239485 @default.
- W4367175044 cites W2151100311 @default.
- W4367175044 cites W2159666276 @default.
- W4367175044 cites W2161458854 @default.
- W4367175044 cites W2162337442 @default.
- W4367175044 cites W2186629139 @default.
- W4367175044 cites W2313007433 @default.
- W4367175044 cites W2329116021 @default.
- W4367175044 cites W2557141247 @default.
- W4367175044 cites W2600347335 @default.
- W4367175044 cites W2625366743 @default.
- W4367175044 cites W2723539103 @default.
- W4367175044 cites W2727604819 @default.
- W4367175044 cites W2741457765 @default.
- W4367175044 cites W2806064585 @default.
- W4367175044 cites W2889506661 @default.
- W4367175044 cites W2908535040 @default.
- W4367175044 cites W2911011964 @default.
- W4367175044 cites W2939528548 @default.
- W4367175044 cites W2956225796 @default.
- W4367175044 cites W2962169757 @default.
- W4367175044 cites W2970412630 @default.
- W4367175044 cites W3033261685 @default.
- W4367175044 cites W3048507351 @default.
- W4367175044 cites W3080629152 @default.
- W4367175044 cites W3088173406 @default.
- W4367175044 cites W3092114769 @default.
- W4367175044 cites W3101888437 @default.
- W4367175044 cites W3161765141 @default.
- W4367175044 cites W3166016467 @default.
- W4367175044 cites W3170820416 @default.
- W4367175044 cites W3193834526 @default.
- W4367175044 cites W3200479416 @default.
- W4367175044 cites W3201532832 @default.
- W4367175044 cites W3207725325 @default.
- W4367175044 cites W3215284682 @default.
- W4367175044 cites W4206416282 @default.
- W4367175044 cites W4210480986 @default.
- W4367175044 cites W4210849595 @default.
- W4367175044 cites W4229001621 @default.
- W4367175044 cites W4229048576 @default.
- W4367175044 cites W4232976656 @default.
- W4367175044 cites W4242443216 @default.
- W4367175044 cites W4247172809 @default.
- W4367175044 cites W4281567558 @default.
- W4367175044 cites W4306757577 @default.
- W4367175044 cites W4307515255 @default.
- W4367175044 cites W4308183941 @default.
- W4367175044 cites W4308291843 @default.
- W4367175044 doi "https://doi.org/10.1080/1744666x.2023.2206119" @default.
- W4367175044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37103889" @default.
- W4367175044 hasPublicationYear "2023" @default.
- W4367175044 type Work @default.
- W4367175044 citedByCount "1" @default.
- W4367175044 countsByYear W43671750442023 @default.
- W4367175044 crossrefType "journal-article" @default.
- W4367175044 hasAuthorship W4367175044A5013453825 @default.
- W4367175044 hasAuthorship W4367175044A5042356850 @default.
- W4367175044 hasAuthorship W4367175044A5055078486 @default.
- W4367175044 hasAuthorship W4367175044A5067563722 @default.
- W4367175044 hasBestOaLocation W43671750441 @default.
- W4367175044 hasConcept C126322002 @default.
- W4367175044 hasConcept C134018914 @default.
- W4367175044 hasConcept C159654299 @default.
- W4367175044 hasConcept C197934379 @default.
- W4367175044 hasConcept C203014093 @default.
- W4367175044 hasConcept C2776136866 @default.
- W4367175044 hasConcept C2776804153 @default.
- W4367175044 hasConcept C2779561371 @default.
- W4367175044 hasConcept C2780091579 @default.
- W4367175044 hasConcept C2781184683 @default.
- W4367175044 hasConcept C535046627 @default.
- W4367175044 hasConcept C555293320 @default.