Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367175053> ?p ?o ?g. }
- W4367175053 endingPage "177" @default.
- W4367175053 startingPage "170" @default.
- W4367175053 abstract "Toll-like receptor (TLR) 7/8 and 9 agonists stimulate an innate immune response that supports the development of tumor-specific immunity. Previous studies showed that either agonist individually could cure mice of small tumors and that when used in combination, they could prevent the progression of larger tumors (>300 mm 3 ). To examine whether these agents combined could control metastatic disease, syngeneic mice were challenged with the highly aggressive 66cl4 triple-negative breast tumor cell line. Treatment was not initiated until pulmonary metastases were established, as verified by bioluminescent imaging of luciferase-tagged tumor cells. Results show that combined therapy with TLR7/8 and TLR9 agonists delivered to both primary and metastatic tumor sites significantly reduced tumor burden and extended survival. The inclusion of cyclophosphamide and anti-PD-L1 resulted in optimal tumor control, characterized by a 5-fold increase in the average duration of survival." @default.
- W4367175053 created "2023-04-28" @default.
- W4367175053 creator A5002584399 @default.
- W4367175053 creator A5020952032 @default.
- W4367175053 creator A5043470455 @default.
- W4367175053 date "2023-04-28" @default.
- W4367175053 modified "2023-09-27" @default.
- W4367175053 title "TLR Agonist Therapy of Metastatic Breast Cancer in Mice" @default.
- W4367175053 cites W1504879144 @default.
- W4367175053 cites W1512675081 @default.
- W4367175053 cites W1542775986 @default.
- W4367175053 cites W1582847607 @default.
- W4367175053 cites W1585754595 @default.
- W4367175053 cites W1826768019 @default.
- W4367175053 cites W1893566975 @default.
- W4367175053 cites W1984618863 @default.
- W4367175053 cites W1988723336 @default.
- W4367175053 cites W1991636753 @default.
- W4367175053 cites W1994391392 @default.
- W4367175053 cites W1996641994 @default.
- W4367175053 cites W1998794592 @default.
- W4367175053 cites W2004280628 @default.
- W4367175053 cites W2006749087 @default.
- W4367175053 cites W2033441782 @default.
- W4367175053 cites W2037381647 @default.
- W4367175053 cites W2047110135 @default.
- W4367175053 cites W2050841284 @default.
- W4367175053 cites W2051998002 @default.
- W4367175053 cites W2057754694 @default.
- W4367175053 cites W2059884673 @default.
- W4367175053 cites W2084692958 @default.
- W4367175053 cites W2100413206 @default.
- W4367175053 cites W2105757811 @default.
- W4367175053 cites W2107752337 @default.
- W4367175053 cites W2118471749 @default.
- W4367175053 cites W2121044753 @default.
- W4367175053 cites W2124999867 @default.
- W4367175053 cites W2126397566 @default.
- W4367175053 cites W2128940859 @default.
- W4367175053 cites W2129053095 @default.
- W4367175053 cites W2131419135 @default.
- W4367175053 cites W2131567916 @default.
- W4367175053 cites W2131577873 @default.
- W4367175053 cites W2144798464 @default.
- W4367175053 cites W2147547193 @default.
- W4367175053 cites W2151777859 @default.
- W4367175053 cites W2169035834 @default.
- W4367175053 cites W2170123390 @default.
- W4367175053 cites W2170612601 @default.
- W4367175053 cites W2419582720 @default.
- W4367175053 cites W2509486054 @default.
- W4367175053 cites W2781905683 @default.
- W4367175053 cites W3007539640 @default.
- W4367175053 cites W3046123570 @default.
- W4367175053 cites W3160126603 @default.
- W4367175053 cites W4211032970 @default.
- W4367175053 cites W4361866506 @default.
- W4367175053 cites W2098751820 @default.
- W4367175053 doi "https://doi.org/10.1097/cji.0000000000000467" @default.
- W4367175053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37103328" @default.
- W4367175053 hasPublicationYear "2023" @default.
- W4367175053 type Work @default.
- W4367175053 citedByCount "0" @default.
- W4367175053 crossrefType "journal-article" @default.
- W4367175053 hasAuthorship W4367175053A5002584399 @default.
- W4367175053 hasAuthorship W4367175053A5020952032 @default.
- W4367175053 hasAuthorship W4367175053A5043470455 @default.
- W4367175053 hasBestOaLocation W43671750532 @default.
- W4367175053 hasConcept C104317684 @default.
- W4367175053 hasConcept C121608353 @default.
- W4367175053 hasConcept C126322002 @default.
- W4367175053 hasConcept C143998085 @default.
- W4367175053 hasConcept C150194340 @default.
- W4367175053 hasConcept C170493617 @default.
- W4367175053 hasConcept C190727270 @default.
- W4367175053 hasConcept C2775930923 @default.
- W4367175053 hasConcept C2776694085 @default.
- W4367175053 hasConcept C2776755627 @default.
- W4367175053 hasConcept C2777701055 @default.
- W4367175053 hasConcept C2778938600 @default.
- W4367175053 hasConcept C2779013556 @default.
- W4367175053 hasConcept C2779138994 @default.
- W4367175053 hasConcept C2780283643 @default.
- W4367175053 hasConcept C502942594 @default.
- W4367175053 hasConcept C530470458 @default.
- W4367175053 hasConcept C55493867 @default.
- W4367175053 hasConcept C71924100 @default.
- W4367175053 hasConcept C86803240 @default.
- W4367175053 hasConceptScore W4367175053C104317684 @default.
- W4367175053 hasConceptScore W4367175053C121608353 @default.
- W4367175053 hasConceptScore W4367175053C126322002 @default.
- W4367175053 hasConceptScore W4367175053C143998085 @default.
- W4367175053 hasConceptScore W4367175053C150194340 @default.
- W4367175053 hasConceptScore W4367175053C170493617 @default.
- W4367175053 hasConceptScore W4367175053C190727270 @default.
- W4367175053 hasConceptScore W4367175053C2775930923 @default.
- W4367175053 hasConceptScore W4367175053C2776694085 @default.
- W4367175053 hasConceptScore W4367175053C2776755627 @default.