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- W4367175054 abstract "Female bias is highly prevalent in conditions such as adrenal cortex hyperplasia and neoplasia, but the reasons behind this phenomenon are poorly understood. In this study, we show that overexpression of the secreted WNT agonist R-spondin 1 (RSPO1) leads to ectopic activation of WNT/β-catenin signaling and causes sex-specific adrenocortical hyperplasia in mice. Although female adrenals show ectopic proliferation, male adrenals display excessive immune system activation and cortical thinning. Using a combination of genetic manipulations and hormonal treatment, we show that gonadal androgens suppress ectopic proliferation in the adrenal cortex and determine the selective regulation of the WNT-related genes Axin2 and Wnt4. Notably, genetic removal of androgen receptor (AR) from adrenocortical cells restores the mitogenic effect of WNT/β-catenin signaling. This is the first demonstration that AR activity in the adrenal cortex determines susceptibility to canonical WNT signaling-induced hyperplasia." @default.
- W4367175054 created "2023-04-28" @default.
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- W4367175054 date "2023-06-01" @default.
- W4367175054 modified "2023-10-08" @default.
- W4367175054 title "Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice" @default.
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- W4367175054 cites W1977859620 @default.
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- W4367175054 cites W1996133111 @default.
- W4367175054 cites W1999276992 @default.
- W4367175054 cites W2003456330 @default.
- W4367175054 cites W2017294587 @default.
- W4367175054 cites W2045022304 @default.
- W4367175054 cites W2052746575 @default.
- W4367175054 cites W2071375391 @default.
- W4367175054 cites W2074033866 @default.
- W4367175054 cites W2078060536 @default.
- W4367175054 cites W2085442947 @default.
- W4367175054 cites W2095670260 @default.
- W4367175054 cites W2098622295 @default.
- W4367175054 cites W2102512718 @default.
- W4367175054 cites W2105322502 @default.
- W4367175054 cites W2105695548 @default.
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- W4367175054 cites W2130410032 @default.
- W4367175054 cites W2134359750 @default.
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- W4367175054 cites W2141197851 @default.
- W4367175054 cites W2147054025 @default.
- W4367175054 cites W2156688148 @default.
- W4367175054 cites W2165087323 @default.
- W4367175054 cites W2166045505 @default.
- W4367175054 cites W2167380532 @default.
- W4367175054 cites W2171996338 @default.
- W4367175054 cites W2173106369 @default.
- W4367175054 cites W2336089418 @default.
- W4367175054 cites W2341186316 @default.
- W4367175054 cites W2346239022 @default.
- W4367175054 cites W2410498954 @default.
- W4367175054 cites W2416423710 @default.
- W4367175054 cites W2423003722 @default.
- W4367175054 cites W2495166363 @default.
- W4367175054 cites W2506177002 @default.
- W4367175054 cites W2518536270 @default.
- W4367175054 cites W2519575842 @default.
- W4367175054 cites W2537989070 @default.
- W4367175054 cites W2555524932 @default.
- W4367175054 cites W2605070587 @default.
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- W4367175054 cites W2743410506 @default.
- W4367175054 cites W2774907524 @default.
- W4367175054 cites W2785279119 @default.
- W4367175054 cites W2912378470 @default.
- W4367175054 cites W2917741054 @default.
- W4367175054 cites W2946571865 @default.
- W4367175054 cites W2947757040 @default.
- W4367175054 cites W2957654649 @default.
- W4367175054 cites W2961432668 @default.
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- W4367175054 doi "https://doi.org/10.1242/dmm.050053" @default.
- W4367175054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37102205" @default.
- W4367175054 hasPublicationYear "2023" @default.
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