Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367175084> ?p ?o ?g. }
- W4367175084 abstract "In contrast to significant advances in the management of patients with chronic heart failure over the past few years, there has been little change in how patients with acute heart failure are treated. Symptoms and signs of fluid overload are the primary reason for hospitalization of patients who experience acute decompensation of heart failure. Intravenous loop diuretics remain the mainstay of therapy in this patient population, with a significant subset of them showing suboptimal response to these agents leading to incomplete decongestion at the time of discharge. Combination diuretic therapy, that is, using loop diuretics along with an add-on agent, is a widely applied strategy to counter renal sodium avidity through sequential blockade of sodium absorption within renal tubules. The choice of the second diuretic is affected by several factors, including the site of action, the anticipated secondary effects, and the available evidence on their efficacy and safety. While the current guidelines recommend combination diuretic therapy as a viable option to overcome suboptimal response to loop diuretics, it is also acknowledged that this strategy is not supported by strong evidence and remains an area of uncertainty. The recent publication of landmark studies has regenerated the interest in sequential nephron blockade. In this article, we provide an overview of the results of the key studies on combination diuretic therapy in the setting of acute heart failure and discuss their findings primarily with regard to the effect on renal sodium avidity and cardiorenal outcomes." @default.
- W4367175084 created "2023-04-28" @default.
- W4367175084 creator A5026155881 @default.
- W4367175084 date "2023-04-27" @default.
- W4367175084 modified "2023-10-17" @default.
- W4367175084 title "Combination Diuretic Therapy to Counter Renal Sodium Avidity in Acute Heart Failure" @default.
- W4367175084 cites W1075135446 @default.
- W4367175084 cites W1856995505 @default.
- W4367175084 cites W1975402385 @default.
- W4367175084 cites W1979049225 @default.
- W4367175084 cites W2003470142 @default.
- W4367175084 cites W2013448178 @default.
- W4367175084 cites W2020204145 @default.
- W4367175084 cites W2023519267 @default.
- W4367175084 cites W2046339602 @default.
- W4367175084 cites W2047636934 @default.
- W4367175084 cites W2050682659 @default.
- W4367175084 cites W2055020815 @default.
- W4367175084 cites W2071369944 @default.
- W4367175084 cites W2111783935 @default.
- W4367175084 cites W2115374758 @default.
- W4367175084 cites W2117890587 @default.
- W4367175084 cites W2119875370 @default.
- W4367175084 cites W2139359396 @default.
- W4367175084 cites W2141703599 @default.
- W4367175084 cites W2150192337 @default.
- W4367175084 cites W2159319899 @default.
- W4367175084 cites W2167809006 @default.
- W4367175084 cites W2169560588 @default.
- W4367175084 cites W2208030318 @default.
- W4367175084 cites W2271304487 @default.
- W4367175084 cites W2334007412 @default.
- W4367175084 cites W2346922973 @default.
- W4367175084 cites W2409027410 @default.
- W4367175084 cites W2519829957 @default.
- W4367175084 cites W2548301463 @default.
- W4367175084 cites W2578604801 @default.
- W4367175084 cites W2596201728 @default.
- W4367175084 cites W2611341068 @default.
- W4367175084 cites W2726497265 @default.
- W4367175084 cites W2736262452 @default.
- W4367175084 cites W2736967138 @default.
- W4367175084 cites W2751295531 @default.
- W4367175084 cites W2769599269 @default.
- W4367175084 cites W2778358228 @default.
- W4367175084 cites W278313891 @default.
- W4367175084 cites W2790066766 @default.
- W4367175084 cites W2808021837 @default.
- W4367175084 cites W2890448542 @default.
- W4367175084 cites W2903080069 @default.
- W4367175084 cites W2929697808 @default.
- W4367175084 cites W2939222610 @default.
- W4367175084 cites W2943375946 @default.
- W4367175084 cites W2944409590 @default.
- W4367175084 cites W2945750558 @default.
- W4367175084 cites W2948205308 @default.
- W4367175084 cites W2959532448 @default.
- W4367175084 cites W2964795371 @default.
- W4367175084 cites W2985754329 @default.
- W4367175084 cites W2994666518 @default.
- W4367175084 cites W2995550955 @default.
- W4367175084 cites W3000647500 @default.
- W4367175084 cites W3005028686 @default.
- W4367175084 cites W3010369848 @default.
- W4367175084 cites W3015126547 @default.
- W4367175084 cites W3025899746 @default.
- W4367175084 cites W3081830235 @default.
- W4367175084 cites W3089283105 @default.
- W4367175084 cites W3093740913 @default.
- W4367175084 cites W3093851112 @default.
- W4367175084 cites W3106776335 @default.
- W4367175084 cites W3127372290 @default.
- W4367175084 cites W3128854844 @default.
- W4367175084 cites W3154453810 @default.
- W4367175084 cites W3193598686 @default.
- W4367175084 cites W3199575284 @default.
- W4367175084 cites W3214709780 @default.
- W4367175084 cites W4214929055 @default.
- W4367175084 cites W4214940159 @default.
- W4367175084 cites W4223477047 @default.
- W4367175084 cites W4281742742 @default.
- W4367175084 cites W4283720835 @default.
- W4367175084 cites W4288176202 @default.
- W4367175084 cites W4292851383 @default.
- W4367175084 cites W4293872386 @default.
- W4367175084 cites W4294817235 @default.
- W4367175084 cites W4302760467 @default.
- W4367175084 cites W4303476222 @default.
- W4367175084 cites W4306684314 @default.
- W4367175084 cites W4308183941 @default.
- W4367175084 cites W4309908777 @default.
- W4367175084 cites W4320717321 @default.
- W4367175084 doi "https://doi.org/10.2215/cjn.0000000000000188" @default.
- W4367175084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37102974" @default.
- W4367175084 hasPublicationYear "2023" @default.
- W4367175084 type Work @default.
- W4367175084 citedByCount "3" @default.
- W4367175084 countsByYear W43671750842023 @default.
- W4367175084 crossrefType "journal-article" @default.
- W4367175084 hasAuthorship W4367175084A5026155881 @default.