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- W4367176098 abstract "Infection with the protozoan Toxoplasma gondii induces changes in neurotransmission, neuroinflammation, and behavior, yet it remains elusive how these changes come about. In this study we investigated how norepinephrine levels are altered by infection. TINEV (Toxoplasma-induced neuronal extracellular vesicles) isolated from infected noradrenergic cells down-regulated dopamine ß-hydroxylase (DBH) gene expression in human and rodent cells. Here we report that intracerebral injection of TINEVs into the brain is sufficient to induce DBH down-regulation and distrupt catecholaminergic signalling. Further, TINEV treatment induced hypermethylation upstream of the DBH gene. An antisense lncRNA to DBH was found in purified TINEV preparations. Paracrine signalling to induce transcriptional gene silencing and DNA methylation may be a common mode to regulate neurologic function." @default.
- W4367176098 created "2023-04-28" @default.
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- W4367176098 date "2023-04-27" @default.
- W4367176098 modified "2023-10-02" @default.
- W4367176098 title "Infection-induced extracellular vesicles evoke neuronal transcriptional and epigenetic changes" @default.
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- W4367176098 doi "https://doi.org/10.1038/s41598-023-34074-2" @default.
- W4367176098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37106020" @default.
- W4367176098 hasPublicationYear "2023" @default.
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