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- W4367176907 abstract "The composition, sequence, length and type of glycosidic linkage of polysaccharides profoundly affect their biological and physical properties. However, investigation of the structure–function relationship of polysaccharides is hampered by difficulties in accessing well-defined polysaccharides in sufficient quantities. Here we report a chemical approach to precision polysaccharides with native glycosidic linkages via living cationic ring-opening polymerization of 1,6-anhydrosugars. We synthesized well-defined polysaccharides with tunable molecular weight, low dispersity and excellent regio- and stereo-selectivity using a boron trifluoride etherate catalyst and glycosyl fluoride initiators. Computational studies revealed that the reaction propagated through the monomer α-addition to the oxocarbenium and was controlled by the reversible deactivation of the propagating oxocarbenium to form the glycosyl fluoride dormant species. Our method afforded a facile and scalable pathway to multiple biologically relevant precision polysaccharides, including d-glucan, d-mannan and an unusual l-glucan. We demonstrated that catalytic depolymerization of precision polysaccharides efficiently regenerated monomers, suggesting their potential utility as a class of chemically recyclable materials with tailored thermal and mechanical properties. The inability to access well-defined polysaccharides in sufficient quantities has hampered our understanding of their structure–function relationships. Now it has been shown that native precision polysaccharides can be readily prepared via living polymerization of 1,6-anhydrosugars. The obtained polymers display excellent chemical recyclability, suggesting their potential utility as a class of sustainable materials." @default.
- W4367176907 created "2023-04-28" @default.
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- W4367176907 date "2023-04-27" @default.
- W4367176907 modified "2023-10-05" @default.
- W4367176907 title "Precision native polysaccharides from living polymerization of anhydrosugars" @default.
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- W4367176907 doi "https://doi.org/10.1038/s41557-023-01193-2" @default.
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