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• W4367178332 abstract "Abstract Background Accumulating evidence indicates that gut microbiota closely correlates with the tumorigenesis of digestive system cancers (DSCs). However, whether the causality between gut microbiota and DSCs exists is unknown. Methods Genome-wide association study (GWAS) summary statistics of gut microbiota and DSCs and the bidirectional two-sample MR analysis were utilized to assess the causality between gut microbiota and DSCs. Sensitivity analyses were performed to evaluate the robustness of our results. Results We found that genus Eggerthella (OR = 0.464, 95%CI: 0.27 to 0.796, P = 0.005) was negatively associated with the risk of gastric cancer. Genetically predicted genus Lachnospiraceae FCS020 group (OR = 0.607, 95%CI: 0.439 to 0.84, P = 0.003) correlated with a lower risk of colorectal cancer, and genus Turicibacter (OR = 0.271, 95%CI: 0.109 to 0.676, P = 0.005) was a protective factor for liver cancer. In the reverse MR, DSCs regulated the relative abundance of specific strains of gut microbiota. Conclusions We comprehensively screened the association of gut microbiota with DSCs via a bidirectional two-sample MR analysis and identified the causality between several microbial taxa and DSCs. Our discoveries are beneficial for the development of novel microbial markers and microbiota-modifying therapeutics for DSCs patients." @default.
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• W4367178332 date "2023-04-27" @default.
• W4367178332 modified "2023-10-16" @default.
• W4367178332 title "Association Between Gut Microbiota and Digestive System Cancers: A Bidirectional Two-Sample Mendelian Randomization Study" @default.
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• W4367178332 doi "https://doi.org/10.21203/rs.3.rs-2854665/v1" @default.
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