Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367178800> ?p ?o ?g. }
- W4367178800 abstract "The frequent mutation of KRAS oncogene in some of the most lethal human cancers has spurred incredible efforts to develop KRAS inhibitors, yet only one covalent inhibitor for the KRASG12C mutant has been approved to date. New venues to interfere with KRAS signaling are desperately needed. Here, we report a “localized oxidation-coupling” strategy to achieve protein-specific glycan editing on living cells for disrupting KRAS signaling. This glycan remodeling method exhibits excellent protein and sugar specificity and is applicable to different donor sugars and cell types. Attachment of mannotriose to the terminal galactose/N-acetyl-D-galactosamine epitopes of integrin αvβ3, a membrane receptor upstream of KRAS, blocks its binding to galectin-3, suppresses the activation of KRAS and downstream effectors, and mitigates KRAS-driven malignant phenotypes. Our work represents the first successful attempt to interfere with KRAS activity by manipulating membrane receptor glycosylation." @default.
- W4367178800 created "2023-04-28" @default.
- W4367178800 creator A5000432967 @default.
- W4367178800 creator A5002556086 @default.
- W4367178800 creator A5010807393 @default.
- W4367178800 creator A5012661141 @default.
- W4367178800 creator A5014674714 @default.
- W4367178800 creator A5019257366 @default.
- W4367178800 creator A5025634034 @default.
- W4367178800 creator A5035571017 @default.
- W4367178800 creator A5037299407 @default.
- W4367178800 creator A5050469940 @default.
- W4367178800 creator A5052848702 @default.
- W4367178800 creator A5053075491 @default.
- W4367178800 creator A5060857183 @default.
- W4367178800 creator A5062233182 @default.
- W4367178800 creator A5067548058 @default.
- W4367178800 creator A5069528198 @default.
- W4367178800 creator A5081221478 @default.
- W4367178800 date "2023-05-12" @default.
- W4367178800 modified "2023-10-16" @default.
- W4367178800 title "Protein‐Targeted Glycan Editing on Living Cells Disrupts KRAS Signaling" @default.
- W4367178800 cites W1147913471 @default.
- W4367178800 cites W1607041879 @default.
- W4367178800 cites W1971849905 @default.
- W4367178800 cites W1977598450 @default.
- W4367178800 cites W1989949259 @default.
- W4367178800 cites W1992724001 @default.
- W4367178800 cites W2029572050 @default.
- W4367178800 cites W2033567679 @default.
- W4367178800 cites W2052039807 @default.
- W4367178800 cites W2055800251 @default.
- W4367178800 cites W2065829276 @default.
- W4367178800 cites W2067302621 @default.
- W4367178800 cites W2081990599 @default.
- W4367178800 cites W2086532397 @default.
- W4367178800 cites W2090158969 @default.
- W4367178800 cites W2094188666 @default.
- W4367178800 cites W2159440209 @default.
- W4367178800 cites W2312299865 @default.
- W4367178800 cites W2508974650 @default.
- W4367178800 cites W2620507130 @default.
- W4367178800 cites W2624616322 @default.
- W4367178800 cites W2755492550 @default.
- W4367178800 cites W2808973017 @default.
- W4367178800 cites W2867022353 @default.
- W4367178800 cites W2901320017 @default.
- W4367178800 cites W2902901751 @default.
- W4367178800 cites W2982321167 @default.
- W4367178800 cites W3003574401 @default.
- W4367178800 cites W3006438030 @default.
- W4367178800 cites W3014644177 @default.
- W4367178800 cites W3029342336 @default.
- W4367178800 cites W3034504519 @default.
- W4367178800 cites W3084102915 @default.
- W4367178800 cites W3094407181 @default.
- W4367178800 cites W3135254146 @default.
- W4367178800 cites W3171214906 @default.
- W4367178800 cites W3188243150 @default.
- W4367178800 cites W2040623056 @default.
- W4367178800 doi "https://doi.org/10.1002/ange.202218148" @default.
- W4367178800 hasPublicationYear "2023" @default.
- W4367178800 type Work @default.
- W4367178800 citedByCount "0" @default.
- W4367178800 crossrefType "journal-article" @default.
- W4367178800 hasAuthorship W4367178800A5000432967 @default.
- W4367178800 hasAuthorship W4367178800A5002556086 @default.
- W4367178800 hasAuthorship W4367178800A5010807393 @default.
- W4367178800 hasAuthorship W4367178800A5012661141 @default.
- W4367178800 hasAuthorship W4367178800A5014674714 @default.
- W4367178800 hasAuthorship W4367178800A5019257366 @default.
- W4367178800 hasAuthorship W4367178800A5025634034 @default.
- W4367178800 hasAuthorship W4367178800A5035571017 @default.
- W4367178800 hasAuthorship W4367178800A5037299407 @default.
- W4367178800 hasAuthorship W4367178800A5050469940 @default.
- W4367178800 hasAuthorship W4367178800A5052848702 @default.
- W4367178800 hasAuthorship W4367178800A5053075491 @default.
- W4367178800 hasAuthorship W4367178800A5060857183 @default.
- W4367178800 hasAuthorship W4367178800A5062233182 @default.
- W4367178800 hasAuthorship W4367178800A5067548058 @default.
- W4367178800 hasAuthorship W4367178800A5069528198 @default.
- W4367178800 hasAuthorship W4367178800A5081221478 @default.
- W4367178800 hasConcept C104317684 @default.
- W4367178800 hasConcept C108625454 @default.
- W4367178800 hasConcept C185592680 @default.
- W4367178800 hasConcept C206212055 @default.
- W4367178800 hasConcept C2777313579 @default.
- W4367178800 hasConcept C2781187634 @default.
- W4367178800 hasConcept C501734568 @default.
- W4367178800 hasConcept C502942594 @default.
- W4367178800 hasConcept C51785407 @default.
- W4367178800 hasConcept C55493867 @default.
- W4367178800 hasConcept C86803240 @default.
- W4367178800 hasConcept C95444343 @default.
- W4367178800 hasConceptScore W4367178800C104317684 @default.
- W4367178800 hasConceptScore W4367178800C108625454 @default.
- W4367178800 hasConceptScore W4367178800C185592680 @default.
- W4367178800 hasConceptScore W4367178800C206212055 @default.
- W4367178800 hasConceptScore W4367178800C2777313579 @default.
- W4367178800 hasConceptScore W4367178800C2781187634 @default.