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- W4367179632 abstract "<p>FLASH irradiation protects synaptic density and spine morphology, 6 months after irradiation. <b>A,</b> Representative images of synaptophysin (red), DAPI (blue; Scale bar = 100 μm). <b>B,</b> Representative image of Homer1a (red)/Bassoon (green), respectively (Scale bar = 10 μm and 2 μm in the zoomed image). <b>C</b> and <b>D</b>, Quantification of synaptic density using synaptophysin found that FLASH did not induce dendritic disruptions that were observed in mice exposed to CONV-RT in both the Hippocampus and mPFC. <b>E</b> and <b>F</b>, Quantification of Homer1a and Bassoon spots within 120 nm of each other. Male and female mice exhibited no differences between presynaptic and postsynaptic binding after FLASH or CONV irradiation in the hippocampus or mPFC. All data were analyzed using a one-way ANOVA followed by Bonferroni multiple comparison test (<i>n</i> = 4/sex/treatment, two sections analyzed/region/animal). *, <i>P</i> ≤ 0.05; **, <i>P</i> ≤ 0.01; ***, <i>P</i> ≤ 0.001; ****, <i>P</i> ≤ 0.0001; ns, no significance.</p>" @default.
- W4367179632 created "2023-04-28" @default.
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- W4367179632 date "2023-04-27" @default.
- W4367179632 modified "2023-10-18" @default.
- W4367179632 title "FIGURE 5 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy" @default.
- W4367179632 doi "https://doi.org/10.1158/2767-9764.22709782.v1" @default.
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