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- W4367180690 abstract "A case of poisoning involving two young children was reported to the Nouvelle-Aquitaine poison control center in 2021. Both children had consumed baits prepared with a liquid rodenticide and rapidly developed severe digestive and then neurological and cardiac signs. In both cases the outcome was fatal. The packaging of the product was confusing, suggesting that it contained a VKA. However, the clinical picture was incompatible with this conjecture and a collegiality between the clinical toxicologists and analysts made it possible to evoke the compatibility of the clinical picture with a poisoning by sodium fluoroacetate. This was quickly confirmed analytically by LC-HRMS. Fluoroacetate is a metabolic poison capable of blocking the Krebs cycle. The blockage of the cycle leads to lactic acidosis, ATP depletion and indirectly to hyperammonia. This intoxication also includes profound hypocalcaemia and hypoglycaemia. The first symptoms appear very quickly and the treatment remains purely symptomatic, and there is currently no antidote. There are relatively few cases described in the literature, which is surprising given the extreme seriousness of sodium fluoroacetate intoxication, particularly in children." @default.
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- W4367180690 date "2023-09-01" @default.
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- W4367180690 title "Fatal case of sodium fluoroacetate poisoning in two young children" @default.
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- W4367180690 doi "https://doi.org/10.1016/j.toxac.2023.04.002" @default.
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