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- W4367180742 abstract "Abstract Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on disease pathophysiology is essential for enhancing their therapeutic effects in periodontitis treatment. As promising localized drug delivery systems and tissue engineering scaffolds, hydrogels have gained significant interest for controlled and sustained release of bioactive agents in periodontal applications. The rational design of bioactive hydrogels can facilitate bacterial control and modulate destructive host inflammation, thereby preventing the progression of periodontitis. In this review, the pathophysiological mechanisms underlying periodontitis as fundamental principles for the design of functional hydrogel systems are first introduced. In the following part, an overview is systematically provided of the types and functions of the bioactive hydrogel systems loaded with anti‐bacterial and anti‐inflammatory agents for periodontal delivery. Finally, the remaining challenges and future perspectives of hydrogel delivery systems for periodontal applications are proposed. It is believed that this review will inspire the rational design and development of innovative functional hydrogel biomaterials toward periodontal therapy." @default.
- W4367180742 created "2023-04-28" @default.
- W4367180742 creator A5000283319 @default.
- W4367180742 creator A5011554093 @default.
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- W4367180742 creator A5036338648 @default.
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- W4367180742 creator A5039575606 @default.
- W4367180742 creator A5086537762 @default.
- W4367180742 date "2023-04-27" @default.
- W4367180742 modified "2023-10-18" @default.
- W4367180742 title "Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications" @default.
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