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- W4367182017 abstract "Acute lymphoblastic leukemia (ALL) disseminates with high prevalence to the central nervous system (CNS) in a process resembling aspects of the CNS surveillance of normal immune cells as well as aspects of brain metastasis from solid cancers. Importantly, inside the CNS, the ALL blasts are typically confined within the cerebrospinal fluid (CSF)-filled cavities of the subarachnoid space, which they use as a sanctuary protected from both chemotherapy and immune cells. At present, high cumulative doses of intrathecal chemotherapy are administered to patients, but this is associated with neurotoxicity and CNS relapse still occurs. Thus, it is imperative to identify markers and novel therapy targets specific to CNS ALL. Integrins represent a family of adhesion molecules involved in cell-cell and cell-matrix interactions, implicated in the adhesion and migration of metastatic cancer cells, normal immune cells, and leukemic blasts. The ability of integrins to also facilitate cell-adhesion mediated drug resistance, combined with recent discoveries of integrin-dependent routes of leukemic cells into the CNS, have sparked a renewed interest in integrins as markers and therapeutic targets in CNS leukemia. Here, we review the roles of integrins in CNS surveillance by normal lymphocytes, dissemination to the CNS by ALL cells, and brain metastasis from solid cancers. Furthermore, we discuss whether ALL dissemination to the CNS abides by known hallmarks of metastasis, and the potential roles of integrins in this context." @default.
- W4367182017 created "2023-04-28" @default.
- W4367182017 creator A5004567233 @default.
- W4367182017 creator A5030579881 @default.
- W4367182017 creator A5052351873 @default.
- W4367182017 creator A5086530149 @default.
- W4367182017 date "2023-04-27" @default.
- W4367182017 modified "2023-09-25" @default.
- W4367182017 title "Integrins and the Metastasis-like Dissemination of Acute Lymphoblastic Leukemia to the Central Nervous System" @default.
- W4367182017 cites W105446306 @default.
- W4367182017 cites W1488960198 @default.
- W4367182017 cites W1495945591 @default.
- W4367182017 cites W1507575667 @default.
- W4367182017 cites W1514064771 @default.
- W4367182017 cites W1526705543 @default.
- W4367182017 cites W1539118102 @default.
- W4367182017 cites W1540450123 @default.
- W4367182017 cites W1576773659 @default.
- W4367182017 cites W1588685142 @default.
- W4367182017 cites W1600560134 @default.
- W4367182017 cites W1618952314 @default.
- W4367182017 cites W173609426 @default.
- W4367182017 cites W1801876107 @default.
- W4367182017 cites W1820889700 @default.
- W4367182017 cites W1870664662 @default.
- W4367182017 cites W1901988103 @default.
- W4367182017 cites W1918975836 @default.
- W4367182017 cites W1935319637 @default.
- W4367182017 cites W1940157337 @default.
- W4367182017 cites W1948291240 @default.
- W4367182017 cites W1950118853 @default.
- W4367182017 cites W1956731911 @default.
- W4367182017 cites W1960336193 @default.
- W4367182017 cites W1964250079 @default.
- W4367182017 cites W1966218963 @default.
- W4367182017 cites W1966438873 @default.
- W4367182017 cites W1969706233 @default.
- W4367182017 cites W1971040598 @default.
- W4367182017 cites W1973000903 @default.
- W4367182017 cites W1973054937 @default.
- W4367182017 cites W1977899668 @default.
- W4367182017 cites W1979108161 @default.
- W4367182017 cites W1983967012 @default.
- W4367182017 cites W1984065010 @default.
- W4367182017 cites W1984182254 @default.
- W4367182017 cites W1985649889 @default.
- W4367182017 cites W1987895181 @default.
- W4367182017 cites W1990124715 @default.
- W4367182017 cites W1991918456 @default.
- W4367182017 cites W1992275212 @default.
- W4367182017 cites W1993746949 @default.
- W4367182017 cites W1993907368 @default.
- W4367182017 cites W1996629296 @default.
- W4367182017 cites W1996629582 @default.
- W4367182017 cites W1996659484 @default.
- W4367182017 cites W1996722399 @default.
- W4367182017 cites W2001627351 @default.
- W4367182017 cites W2003853210 @default.
- W4367182017 cites W2007708721 @default.
- W4367182017 cites W2009355727 @default.
- W4367182017 cites W2010011171 @default.
- W4367182017 cites W2010847848 @default.
- W4367182017 cites W2013269126 @default.
- W4367182017 cites W2015344488 @default.
- W4367182017 cites W2016371380 @default.
- W4367182017 cites W2017165266 @default.
- W4367182017 cites W2021314764 @default.
- W4367182017 cites W2022788095 @default.
- W4367182017 cites W2023291646 @default.
- W4367182017 cites W2024495487 @default.
- W4367182017 cites W2024962984 @default.
- W4367182017 cites W2025880272 @default.
- W4367182017 cites W2027373844 @default.
- W4367182017 cites W2030689322 @default.
- W4367182017 cites W2030701238 @default.
- W4367182017 cites W2034713890 @default.
- W4367182017 cites W2035749206 @default.
- W4367182017 cites W2035809865 @default.
- W4367182017 cites W2037905113 @default.
- W4367182017 cites W2039378498 @default.
- W4367182017 cites W2040022930 @default.
- W4367182017 cites W2040283898 @default.
- W4367182017 cites W2040329520 @default.
- W4367182017 cites W2040379229 @default.
- W4367182017 cites W2042184886 @default.
- W4367182017 cites W2043166238 @default.
- W4367182017 cites W2043222263 @default.
- W4367182017 cites W2045284607 @default.
- W4367182017 cites W2046293919 @default.
- W4367182017 cites W2048654561 @default.
- W4367182017 cites W2049644695 @default.
- W4367182017 cites W2050603039 @default.
- W4367182017 cites W2056990001 @default.
- W4367182017 cites W2057151160 @default.
- W4367182017 cites W2058427733 @default.
- W4367182017 cites W2059558712 @default.
- W4367182017 cites W2060237440 @default.
- W4367182017 cites W2060279158 @default.