Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367182018> ?p ?o ?g. }
- W4367182018 endingPage "025002" @default.
- W4367182018 startingPage "025002" @default.
- W4367182018 abstract "Abstract Minoxidil (Mxd) is a common medication used for hair regrowth in patients exhibiting different types of alopecia, especially androgenetic alopecia (AGA), but it has some negative aspects such as causing adverse effects and having limited permeation through the outer skin layers. In this study, minoxidil was encapsulated into niosomes and then loaded into chitosan nanoparticles and Aloe vera for creating a nanocomposite (Cs@Alo/Nio-Mxd), which will be used as a topical formulation to overcome these difficulties. The various prepared samples were physico-chemically characterised by their loading efficiency, TEM, SEM, zeta potential, FTIR and in vitro release profiles. The hair growth potential of the prepared formulations was evaluated by an in vivo study using rats with induced alopecia. Thirty-six rats with induced alopecia were randomised into six groups of six rats each. Group 1 (Negative control): rats served as normal and were treated with normal saline, Group 2: rats were treated with topical application of empty nanocomposites. Group 3 (Positive control): rats were treated with topical application of 5% Mxd, Group 4: rats were treated with topical application of (Cs-Mxd NPs), Group 5: rats were treated with topical application of (Cs@Alo-Mxd NPs). Group 6: rats were treated with topical application of (Cs@Alo/Nio-Mxd) nanocomposite. All formulations were applied once daily for 21 days. The treated skin was observed, photographed, and its histological features were examined. Results specified that Cs@Alo/Nio-Mxd nanocomposite could be preferentially deposited into the hair follicles, causing a significant increase ( p < 0.05) in skin thickness, total hair follicle number per field, hair follicle diameter, hypodermis hair follicle number and anagen induction percentage." @default.
- W4367182018 created "2023-04-28" @default.
- W4367182018 creator A5000298653 @default.
- W4367182018 creator A5029104798 @default.
- W4367182018 creator A5081264481 @default.
- W4367182018 creator A5086050666 @default.
- W4367182018 date "2023-04-27" @default.
- W4367182018 modified "2023-10-03" @default.
- W4367182018 title "Chitosan and Aloe Vera decorated nanoparticulate system loaded with Minoxidil as a suggested topical formulation for alopecia therapy" @default.
- W4367182018 cites W1969551291 @default.
- W4367182018 cites W1972089141 @default.
- W4367182018 cites W1990139570 @default.
- W4367182018 cites W1992462568 @default.
- W4367182018 cites W2002865604 @default.
- W4367182018 cites W2016711291 @default.
- W4367182018 cites W2023852740 @default.
- W4367182018 cites W2031368999 @default.
- W4367182018 cites W2035355582 @default.
- W4367182018 cites W2037257919 @default.
- W4367182018 cites W2043502318 @default.
- W4367182018 cites W2046806170 @default.
- W4367182018 cites W2056211275 @default.
- W4367182018 cites W2062868514 @default.
- W4367182018 cites W2066432116 @default.
- W4367182018 cites W2076047978 @default.
- W4367182018 cites W2087421919 @default.
- W4367182018 cites W2089481618 @default.
- W4367182018 cites W2091742793 @default.
- W4367182018 cites W2110022232 @default.
- W4367182018 cites W2145548796 @default.
- W4367182018 cites W2322820873 @default.
- W4367182018 cites W2492965413 @default.
- W4367182018 cites W2530865780 @default.
- W4367182018 cites W2649577577 @default.
- W4367182018 cites W2750142910 @default.
- W4367182018 cites W2787985380 @default.
- W4367182018 cites W2942941939 @default.
- W4367182018 cites W2947383051 @default.
- W4367182018 cites W2968810751 @default.
- W4367182018 cites W2975943876 @default.
- W4367182018 cites W3004726103 @default.
- W4367182018 cites W3006711873 @default.
- W4367182018 cites W3100729600 @default.
- W4367182018 cites W3110330458 @default.
- W4367182018 cites W3195902065 @default.
- W4367182018 cites W4200357992 @default.
- W4367182018 cites W4206020574 @default.
- W4367182018 cites W4206487853 @default.
- W4367182018 cites W4220736340 @default.
- W4367182018 cites W4293797337 @default.
- W4367182018 doi "https://doi.org/10.1088/2043-6262/accc7e" @default.
- W4367182018 hasPublicationYear "2023" @default.
- W4367182018 type Work @default.
- W4367182018 citedByCount "2" @default.
- W4367182018 countsByYear W43671820182023 @default.
- W4367182018 crossrefType "journal-article" @default.
- W4367182018 hasAuthorship W4367182018A5000298653 @default.
- W4367182018 hasAuthorship W4367182018A5029104798 @default.
- W4367182018 hasAuthorship W4367182018A5081264481 @default.
- W4367182018 hasAuthorship W4367182018A5086050666 @default.
- W4367182018 hasConcept C126322002 @default.
- W4367182018 hasConcept C127413603 @default.
- W4367182018 hasConcept C13965031 @default.
- W4367182018 hasConcept C16005928 @default.
- W4367182018 hasConcept C160892712 @default.
- W4367182018 hasConcept C178790620 @default.
- W4367182018 hasConcept C185592680 @default.
- W4367182018 hasConcept C197934379 @default.
- W4367182018 hasConcept C2777397205 @default.
- W4367182018 hasConcept C2779404486 @default.
- W4367182018 hasConcept C2779711729 @default.
- W4367182018 hasConcept C2779732960 @default.
- W4367182018 hasConcept C42360764 @default.
- W4367182018 hasConcept C556039675 @default.
- W4367182018 hasConcept C71924100 @default.
- W4367182018 hasConcept C98274493 @default.
- W4367182018 hasConceptScore W4367182018C126322002 @default.
- W4367182018 hasConceptScore W4367182018C127413603 @default.
- W4367182018 hasConceptScore W4367182018C13965031 @default.
- W4367182018 hasConceptScore W4367182018C16005928 @default.
- W4367182018 hasConceptScore W4367182018C160892712 @default.
- W4367182018 hasConceptScore W4367182018C178790620 @default.
- W4367182018 hasConceptScore W4367182018C185592680 @default.
- W4367182018 hasConceptScore W4367182018C197934379 @default.
- W4367182018 hasConceptScore W4367182018C2777397205 @default.
- W4367182018 hasConceptScore W4367182018C2779404486 @default.
- W4367182018 hasConceptScore W4367182018C2779711729 @default.
- W4367182018 hasConceptScore W4367182018C2779732960 @default.
- W4367182018 hasConceptScore W4367182018C42360764 @default.
- W4367182018 hasConceptScore W4367182018C556039675 @default.
- W4367182018 hasConceptScore W4367182018C71924100 @default.
- W4367182018 hasConceptScore W4367182018C98274493 @default.
- W4367182018 hasIssue "2" @default.
- W4367182018 hasLocation W43671820181 @default.
- W4367182018 hasOpenAccess W4367182018 @default.
- W4367182018 hasPrimaryLocation W43671820181 @default.
- W4367182018 hasRelatedWork W1734771809 @default.
- W4367182018 hasRelatedWork W2024050689 @default.