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- W4367183041 endingPage "7892" @default.
- W4367183041 startingPage "7892" @default.
- W4367183041 abstract "Multidrug-resistant Gram-negative bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, and members of the Enterobacterales order are a challenging multi-sectorial and global threat, being listed by the WHO in the priority list of pathogens requiring the urgent discovery and development of therapeutic strategies. We present here an overview of the antibiotic resistance profiles and epidemiology of Gram-negative pathogens listed in the ESCAPE group circulating in Romania. The review starts with a discussion of the mechanisms and clinical significance of Gram-negative bacteria, the most frequent genetic determinants of resistance, and then summarizes and discusses the epidemiological studies reported for A. baumannii, P. aeruginosa, and Enterobacterales-resistant strains circulating in Romania, both in hospital and veterinary settings and mirrored in the aquatic environment. The Romanian landscape of Gram-negative pathogens included in the ESCAPE list reveals that all significant, clinically relevant, globally spread antibiotic resistance genes and carrying platforms are well established in different geographical areas of Romania and have already been disseminated beyond clinical settings." @default.
- W4367183041 created "2023-04-28" @default.
- W4367183041 creator A5001059217 @default.
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- W4367183041 creator A5035743675 @default.
- W4367183041 creator A5039986426 @default.
- W4367183041 creator A5084077366 @default.
- W4367183041 date "2023-04-26" @default.
- W4367183041 modified "2023-09-30" @default.
- W4367183041 title "Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors" @default.
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