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• W4367183108 abstract "Abstract The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin. The organization of somatosensory endings is essential to their functions, yet the mechanisms which regulate this organization remain unclear. Using a combination of genetic and molecular labeling approaches, we examined the development of mouse hair follicle-innervating low-threshold mechanoreceptors (LTMRs) and explored competition for innervation targets as a mechanism involved in the patterning of their receptive fields. We show that follicle innervating neurons are present in the skin at birth and that LTMR receptive fields gradually add follicle-innervating endings during the first two postnatal weeks. Using a constitutive Bax knockout to increase the number of neurons in adult animals, we show that two LTMR subtypes have differential responses to an increase in neuronal population size: Aδ-LTMR neurons shrink their receptive fields to accommodate the increased number of neurons innervating the skin, while C-LTMR neurons do not. Our findings suggest that competition for hair follicles to innervate plays a role in the patterning and organization of follicle-innervating LTMR neurons." @default.
• W4367183108 created "2023-04-28" @default.
• W4367183108 creator A5032059550 @default.
• W4367183108 creator A5041505294 @default.
• W4367183108 date "2023-04-27" @default.
• W4367183108 modified "2023-09-27" @default.
• W4367183108 title "Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition" @default.
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• W4367183108 doi "https://doi.org/10.1186/s13064-023-00170-2" @default.
• W4367183108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37106422" @default.
• W4367183108 hasPublicationYear "2023" @default.
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