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• W4367183783 abstract "Sterols constitute vital structural and regulatory components of eukaryotic cells. In the oleaginous microorganism Schizochytrium sp. S31, the sterol biosynthetic pathway primarily produces cholesterol, stigmasterol, lanosterol, and cycloartenol. However, the sterol biosynthesis pathway and its functional roles in Schizochytrium remain unidentified. Through Schizochytrium genomic data mining and a chemical biology approach, we first in silico elucidated the mevalonate and sterol biosynthesis pathways of Schizochytrium. The results showed that owing to the lack of plastids in Schizochytrium, it is likely to use the mevalonate pathway as the terpenoid backbone pathway to supply isopentenyl diphosphate for the synthesis of sterols, similar to that in fungi and animals. In addition, our analysis revealed a chimeric organization of the Schizochytrium sterol biosynthesis pathway, which possesses features of both algae and animal pathways. Temporal tracking of sterol profiles reveals that sterols play important roles in Schizochytrium growth, carotenoid synthesis, and fatty acid synthesis. Furthermore, the dynamics of fatty acid and transcription levels of genes involved in fatty acid upon chemical inhibitor-induced sterol inhibition reveal possible co-regulation of sterol synthesis and fatty acid synthesis, as the inhibition of sterol synthesis could promote the accumulation of fatty acid in Schizochytrium. Sterol and carotenoid metabolisms are also found possibly co-regulated, as the inhibition of sterols led to decreased carotenoid synthesis through down-regulating the gene HMGR and crtIBY in Schizochytrium. Together, elucidation of the Schizochytrium sterol biosynthesis pathway and its co-regulation with fatty acid synthesis lay the essential foundation for engineering Schizochytrium for the sustainable production of lipids and high-value chemicals." @default.
• W4367183783 created "2023-04-28" @default.
• W4367183783 creator A5010738468 @default.
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• W4367183783 creator A5053720993 @default.
• W4367183783 creator A5055716191 @default.
• W4367183783 date "2023-04-27" @default.
• W4367183783 modified "2023-10-06" @default.
• W4367183783 title "Elucidation of sterol biosynthesis pathway and its co-regulation with fatty acid biosynthesis in the oleaginous marine protist Schizochytrium sp." @default.
• W4367183783 cites W1003742411 @default.
• W4367183783 cites W1247621250 @default.
• W4367183783 cites W1553469602 @default.
• W4367183783 cites W1566896745 @default.
• W4367183783 cites W1851472440 @default.
• W4367183783 cites W1964064737 @default.
• W4367183783 cites W1968248461 @default.
• W4367183783 cites W1968457798 @default.
• W4367183783 cites W1974833847 @default.
• W4367183783 cites W1979129439 @default.
• W4367183783 cites W1979344830 @default.
• W4367183783 cites W1982115860 @default.
• W4367183783 cites W1985236712 @default.
• W4367183783 cites W1996019617 @default.
• W4367183783 cites W1996073861 @default.
• W4367183783 cites W1996228271 @default.
• W4367183783 cites W2000151183 @default.
• W4367183783 cites W2000973674 @default.
• W4367183783 cites W2001012518 @default.
• W4367183783 cites W2023011330 @default.
• W4367183783 cites W2023481684 @default.
• W4367183783 cites W2031271408 @default.
• W4367183783 cites W2034052401 @default.
• W4367183783 cites W2043364597 @default.
• W4367183783 cites W2043642851 @default.
• W4367183783 cites W2045817429 @default.
• W4367183783 cites W2048258966 @default.
• W4367183783 cites W2050289184 @default.
• W4367183783 cites W2051143095 @default.
• W4367183783 cites W2051821524 @default.
• W4367183783 cites W2052002049 @default.
• W4367183783 cites W2058726121 @default.
• W4367183783 cites W2061716618 @default.
• W4367183783 cites W2063802807 @default.
• W4367183783 cites W2070400628 @default.
• W4367183783 cites W2073715954 @default.
• W4367183783 cites W2073984828 @default.
• W4367183783 cites W2085031753 @default.
• W4367183783 cites W2088260215 @default.
• W4367183783 cites W2088364769 @default.
• W4367183783 cites W2101970140 @default.
• W4367183783 cites W2107277218 @default.
• W4367183783 cites W2110763841 @default.
• W4367183783 cites W2111076637 @default.
• W4367183783 cites W2117158343 @default.
• W4367183783 cites W2120327960 @default.
• W4367183783 cites W2121989498 @default.
• W4367183783 cites W2125149319 @default.
• W4367183783 cites W2133711112 @default.
• W4367183783 cites W2134529777 @default.
• W4367183783 cites W2144676492 @default.
• W4367183783 cites W2146544786 @default.
• W4367183783 cites W2146948565 @default.
• W4367183783 cites W2148668859 @default.
• W4367183783 cites W2148735872 @default.
• W4367183783 cites W2153271274 @default.
• W4367183783 cites W2155918029 @default.
• W4367183783 cites W2192080449 @default.
• W4367183783 cites W2302459349 @default.
• W4367183783 cites W2596643790 @default.
• W4367183783 cites W2755011935 @default.
• W4367183783 cites W2793523524 @default.
• W4367183783 cites W2808404315 @default.
• W4367183783 cites W2884046262 @default.
• W4367183783 cites W2889096164 @default.
• W4367183783 cites W2901977783 @default.
• W4367183783 cites W2909131232 @default.
• W4367183783 cites W2944497438 @default.
• W4367183783 cites W2948243966 @default.
• W4367183783 cites W2955393186 @default.
• W4367183783 cites W2964834922 @default.
• W4367183783 cites W2972479207 @default.
• W4367183783 cites W2980581135 @default.
• W4367183783 cites W2982718945 @default.
• W4367183783 cites W3003852717 @default.
• W4367183783 cites W3022998324 @default.
• W4367183783 cites W3023190156 @default.
• W4367183783 cites W3041525348 @default.
• W4367183783 cites W3044040031 @default.
• W4367183783 cites W3137056319 @default.
• W4367183783 cites W3212496429 @default.
• W4367183783 cites W3214123312 @default.
• W4367183783 cites W365344764 @default.
• W4367183783 cites W4200168046 @default.
• W4367183783 cites W4200367542 @default.
• W4367183783 cites W4212882217 @default.
• W4367183783 cites W4252021281 @default.
• W4367183783 cites W4255115086 @default.
• W4367183783 doi "https://doi.org/10.3389/fbioe.2023.1188461" @default.
• W4367183783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37180050" @default.

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