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• W4367183896 abstract "New early low-invasive biomarkers are demanded for the management of Oligoarticular Juvenile Idiopathic Arthritis (OJIA), the most common chronic pediatric rheumatic disease in Western countries and a leading cause of disability. A deeper understanding of the molecular basis of OJIA pathophysiology is essential for identifying new biomarkers for earlier disease diagnosis and patient stratification and to guide targeted therapeutic intervention. Proteomic profiling of extracellular vesicles (EVs) released in biological fluids has recently emerged as a minimally invasive approach to elucidate adult arthritis pathogenic mechanisms and identify new biomarkers. However, EV-prot expression and potential as biomarkers in OJIA have not been explored. This study represents the first detailed longitudinal characterization of the EV-proteome in OJIA patients.Fourty-five OJIA patients were recruited at disease onset and followed up for 24 months, and protein expression profiling was carried out by liquid chromatography-tandem mass spectrometry in EVs isolated from plasma (PL) and synovial fluid (SF) samples.We first compared the EV-proteome of SF vs paired PL and identified a panel of EV-prots whose expression was significantly deregulated in SF. Interaction network and GO enrichment analyses performed on deregulated EV-prots through STRING database and ShinyGO webserver revealed enrichment in processes related to cartilage/bone metabolism and inflammation, suggesting their role in OJIA pathogenesis and potential value as early molecular indicators of OJIA development. Comparative analysis of the EV-proteome in PL and SF from OJIA patients vs PL from age/gender-matched control children was then carried out. We detected altered expression of a panel of EV-prots able to differentiate new-onset OJIA patients from control children, potentially representing a disease-associated signature measurable at both the systemic and local levels with diagnostic potential. Deregulated EV-prots were significantly associated with biological processes related to innate immunity, antigen processing and presentation, and cytoskeleton organization. Finally, we ran WGCNA on the SF- and PL-derived EV-prot datasets and identified a few EV-prot modules associated with different clinical parameters stratifying OJIA patients in distinct subgroups.These data provide novel mechanistic insights into OJIA pathophysiology and an important contribution in the search of new candidate molecular biomarkers for the disease." @default.
• W4367183896 created "2023-04-28" @default.
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• W4367183896 date "2023-04-27" @default.
• W4367183896 modified "2023-10-09" @default.
• W4367183896 title "Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers" @default.
• W4367183896 cites W106249247 @default.
• W4367183896 cites W1515429739 @default.
• W4367183896 cites W1560020441 @default.
• W4367183896 cites W1594863916 @default.
• W4367183896 cites W1606004059 @default.
• W4367183896 cites W1902608065 @default.
• W4367183896 cites W1917694766 @default.
• W4367183896 cites W1966327575 @default.
• W4367183896 cites W1972399884 @default.
• W4367183896 cites W1976310007 @default.
• W4367183896 cites W1977098485 @default.
• W4367183896 cites W1979036381 @default.
• W4367183896 cites W1984507087 @default.
• W4367183896 cites W1988952405 @default.
• W4367183896 cites W1991586357 @default.
• W4367183896 cites W1992274603 @default.
• W4367183896 cites W1992308020 @default.
• W4367183896 cites W1994261002 @default.
• W4367183896 cites W1995262329 @default.
• W4367183896 cites W1996584569 @default.
• W4367183896 cites W2002785521 @default.
• W4367183896 cites W2003328421 @default.
• W4367183896 cites W2003585061 @default.
• W4367183896 cites W2005108003 @default.
• W4367183896 cites W2005858950 @default.
• W4367183896 cites W2008948213 @default.
• W4367183896 cites W2009094020 @default.
• W4367183896 cites W2011002011 @default.
• W4367183896 cites W2017854718 @default.
• W4367183896 cites W2022305566 @default.
• W4367183896 cites W2032062578 @default.
• W4367183896 cites W2036054943 @default.
• W4367183896 cites W2036556119 @default.
• W4367183896 cites W2037673858 @default.
• W4367183896 cites W2046507356 @default.
• W4367183896 cites W2046615133 @default.
• W4367183896 cites W2055313665 @default.
• W4367183896 cites W2056012261 @default.
• W4367183896 cites W2062152303 @default.
• W4367183896 cites W2064595835 @default.
• W4367183896 cites W2065054671 @default.
• W4367183896 cites W2072500831 @default.
• W4367183896 cites W2080752012 @default.
• W4367183896 cites W2083251543 @default.
• W4367183896 cites W2086938022 @default.
• W4367183896 cites W2089430367 @default.
• W4367183896 cites W2090332309 @default.
• W4367183896 cites W2093662620 @default.
• W4367183896 cites W2096737028 @default.
• W4367183896 cites W2103511188 @default.
• W4367183896 cites W2111322263 @default.
• W4367183896 cites W2112478769 @default.
• W4367183896 cites W2116951100 @default.
• W4367183896 cites W2119047401 @default.
• W4367183896 cites W2133656640 @default.
• W4367183896 cites W2133854933 @default.
• W4367183896 cites W2133876809 @default.
• W4367183896 cites W2135581618 @default.
• W4367183896 cites W2139124373 @default.
• W4367183896 cites W2140681886 @default.
• W4367183896 cites W2140861987 @default.
• W4367183896 cites W2149193891 @default.
• W4367183896 cites W2165763198 @default.
• W4367183896 cites W2169432812 @default.
• W4367183896 cites W2171000684 @default.
• W4367183896 cites W2171170297 @default.
• W4367183896 cites W2211059366 @default.
• W4367183896 cites W2221264044 @default.
• W4367183896 cites W2271680371 @default.
• W4367183896 cites W2323113905 @default.
• W4367183896 cites W2324552632 @default.
• W4367183896 cites W2325305253 @default.
• W4367183896 cites W2326555481 @default.
• W4367183896 cites W2427671177 @default.
• W4367183896 cites W2463195069 @default.
• W4367183896 cites W2474719271 @default.
• W4367183896 cites W2513003030 @default.
• W4367183896 cites W2551886441 @default.
• W4367183896 cites W2558513068 @default.
• W4367183896 cites W2580175309 @default.
• W4367183896 cites W2584250070 @default.
• W4367183896 cites W2591516566 @default.

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