FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367183923> ?p ?o ?g. }

• W4367183923 abstract "Introduction The causes of thrombocytopenia (TP) in critically ill patients are numerous and heterogeneous. Currently, subphenotype identification is a popular approach to address this problem. Therefore, this study aimed to identify subphenotypes that respond differently to therapeutic interventions in patients with TP using routine clinical data and to improve individualized management of TP. Methods This retrospective study included patients with TP admitted to the intensive care unit (ICU) of Dongyang People’s Hospital during 2010–2020. Subphenotypes were identified using latent profile analysis of 15 clinical variables. The Kaplan–Meier method was used to assess the risk of 30-day mortality for different subphenotypes. Multifactorial Cox regression analysis was used to analyze the relationship between therapeutic interventions and in-hospital mortality for different subphenotypes. Results This study included a total of 1,666 participants. Four subphenotypes were identified by latent profile analysis, with subphenotype 1 being the most abundant and having a low mortality rate. Subphenotype 2 was characterized by respiratory dysfunction, subphenotype 3 by renal insufficiency, and subphenotype 4 by shock-like features. Kaplan–Meier analysis revealed that the four subphenotypes had different in-30-day mortality rates. The multivariate Cox regression analysis indicated a significant interaction between platelet transfusion and subphenotype, with more platelet transfusion associated with a decreased risk of in-hospital mortality in subphenotype 3 [hazard ratio (HR): 0.66, 95% confidence interval (CI): 0.46–0.94]. In addition, there was a significant interaction between fluid intake and subphenotype, with a higher fluid intake being associated with a decreased risk of in-hospital mortality for subphenotype 3 (HR: 0.94, 95% CI: 0.89–0.99 per 1 l increase in fluid intake) and an increased risk of in-hospital mortality for high fluid intake in subphenotypes 1 (HR: 1.10, 95% CI: 1.03–1.18 per 1 l increase in fluid intake) and 2 (HR: 1.19, 95% CI: 1.08–1.32 per 1 l increase in fluid intake). Conclusion Four subphenotypes of TP in critically ill patients with different clinical characteristics and outcomes and differential responses to therapeutic interventions were identified using routine clinical data. These findings can help improve the identification of different subphenotypes in patients with TP for better individualized treatment of patients in the ICU." @default.
• W4367183923 created "2023-04-28" @default.
• W4367183923 creator A5001151167 @default.
• W4367183923 creator A5008656862 @default.
• W4367183923 creator A5014963018 @default.
• W4367183923 creator A5040122093 @default.
• W4367183923 date "2023-04-27" @default.
• W4367183923 modified "2023-10-18" @default.
• W4367183923 title "Identification of subphenotypes in critically ill thrombocytopenic patients with different responses to therapeutic interventions: a retrospective study" @default.
• W4367183923 cites W1964549099 @default.
• W4367183923 cites W1967581330 @default.
• W4367183923 cites W1986284681 @default.
• W4367183923 cites W2012883829 @default.
• W4367183923 cites W2032533636 @default.
• W4367183923 cites W2090330784 @default.
• W4367183923 cites W2107584112 @default.
• W4367183923 cites W2114021851 @default.
• W4367183923 cites W2480375429 @default.
• W4367183923 cites W2515625652 @default.
• W4367183923 cites W2572590842 @default.
• W4367183923 cites W2580396496 @default.
• W4367183923 cites W2610784106 @default.
• W4367183923 cites W2612977276 @default.
• W4367183923 cites W2761685264 @default.
• W4367183923 cites W2768689913 @default.
• W4367183923 cites W2777185046 @default.
• W4367183923 cites W2792277667 @default.
• W4367183923 cites W2831286437 @default.
• W4367183923 cites W2894810674 @default.
• W4367183923 cites W2896434545 @default.
• W4367183923 cites W2904677804 @default.
• W4367183923 cites W2906668661 @default.
• W4367183923 cites W2909277870 @default.
• W4367183923 cites W2923372709 @default.
• W4367183923 cites W2973776359 @default.
• W4367183923 cites W3038116030 @default.
• W4367183923 cites W3084940717 @default.
• W4367183923 cites W3090489412 @default.
• W4367183923 cites W3093087806 @default.
• W4367183923 cites W3108515882 @default.
• W4367183923 cites W3182332828 @default.
• W4367183923 cites W4205876010 @default.
• W4367183923 cites W4213164517 @default.
• W4367183923 cites W4224222931 @default.
• W4367183923 cites W4246837663 @default.
• W4367183923 cites W4292451659 @default.
• W4367183923 cites W4311451988 @default.
• W4367183923 doi "https://doi.org/10.3389/fmed.2023.1166896" @default.
• W4367183923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37181358" @default.
• W4367183923 hasPublicationYear "2023" @default.
• W4367183923 type Work @default.
• W4367183923 citedByCount "0" @default.
• W4367183923 crossrefType "journal-article" @default.
• W4367183923 hasAuthorship W4367183923A5001151167 @default.
• W4367183923 hasAuthorship W4367183923A5008656862 @default.
• W4367183923 hasAuthorship W4367183923A5014963018 @default.
• W4367183923 hasAuthorship W4367183923A5040122093 @default.
• W4367183923 hasBestOaLocation W43671839231 @default.
• W4367183923 hasConcept C118552586 @default.
• W4367183923 hasConcept C126322002 @default.
• W4367183923 hasConcept C177713679 @default.
• W4367183923 hasConcept C194828623 @default.
• W4367183923 hasConcept C207103383 @default.
• W4367183923 hasConcept C27415008 @default.
• W4367183923 hasConcept C44249647 @default.
• W4367183923 hasConcept C50382708 @default.
• W4367183923 hasConcept C71924100 @default.
• W4367183923 hasConceptScore W4367183923C118552586 @default.
• W4367183923 hasConceptScore W4367183923C126322002 @default.
• W4367183923 hasConceptScore W4367183923C177713679 @default.
• W4367183923 hasConceptScore W4367183923C194828623 @default.
• W4367183923 hasConceptScore W4367183923C207103383 @default.
• W4367183923 hasConceptScore W4367183923C27415008 @default.
• W4367183923 hasConceptScore W4367183923C44249647 @default.
• W4367183923 hasConceptScore W4367183923C50382708 @default.
• W4367183923 hasConceptScore W4367183923C71924100 @default.
• W4367183923 hasLocation W43671839231 @default.
• W4367183923 hasLocation W43671839232 @default.
• W4367183923 hasLocation W43671839233 @default.
• W4367183923 hasOpenAccess W4367183923 @default.
• W4367183923 hasPrimaryLocation W43671839231 @default.
• W4367183923 hasRelatedWork W1727188710 @default.
• W4367183923 hasRelatedWork W2088206352 @default.
• W4367183923 hasRelatedWork W2119154902 @default.
• W4367183923 hasRelatedWork W2133235702 @default.
• W4367183923 hasRelatedWork W2135028155 @default.
• W4367183923 hasRelatedWork W2203903734 @default.
• W4367183923 hasRelatedWork W2335177398 @default.
• W4367183923 hasRelatedWork W2904476754 @default.
• W4367183923 hasRelatedWork W2917746345 @default.
• W4367183923 hasRelatedWork W4376871959 @default.
• W4367183923 hasVolume "10" @default.
• W4367183923 isParatext "false" @default.
• W4367183923 isRetracted "false" @default.
• W4367183923 workType "article" @default.