Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367186136> ?p ?o ?g. }
- W4367186136 endingPage "e15872" @default.
- W4367186136 startingPage "e15872" @default.
- W4367186136 abstract "This study aimed to evaluate the efficacy of puerarin and its effect on synaptic plasticity in rats with focal cerebral ischemia (FCI) by modulating the silent mating type information regulation 2 homolog (SIRT1)/hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway. Fifty specific pathogen-free-grade healthy male rats were randomly divided into sham operation group (SOG), model group, low-dose group, medium-dose group, and high-dose group, with 10 rats in each group. The SOG group received sham operation and saline treatment, while the other four groups received the same amount of saline, 25 mg/kg, 50 mg/kg, and 100 mg/kg of puerarin injection, respectively. After modeling, the rats exhibited higher neurological deficit, inflammation, cerebral infarction rate, and lower forelimb motor function as well as lower protein expressions of SIRT1, HIF-1α, VEGF, synaptophysin (SYN), and postsynaptic density protein (PSD)-95. With the treatment of different doses of puerarin, the degree of neurological impairment, impaired motor function, cerebral infarction rate, and the levels of inflammatory factors (interleukin [IL]-1β, IL-6, and intercellular adhesion molecule 1) in brain tissues were reduced; the protein expressions of SIRT1, HIF-1α, VEGF, SYN, and PSD-95 in brain tissues were enhanced, and the synaptic volume density, numerical density, surface density, width of synaptic cleft, and curvature of the synaptic interface in the cerebral cortex were also improved. Notably, the effects of puerarin on the above-mentioned indicators were dose-dependent. Puerarin can improve neurological impairment and forelimb motor function, reduce inflammatory response, inhibit brain edema, regulate synaptic plasticity, and restore the curvature of synaptic interface in rats with FCI, and its mechanism of action may be related to the activation of SIRT1/HIF-1α/VEGF signaling pathway." @default.
- W4367186136 created "2023-04-28" @default.
- W4367186136 creator A5000510955 @default.
- W4367186136 creator A5016634509 @default.
- W4367186136 creator A5021687717 @default.
- W4367186136 creator A5038696969 @default.
- W4367186136 creator A5041005462 @default.
- W4367186136 date "2023-05-01" @default.
- W4367186136 modified "2023-10-01" @default.
- W4367186136 title "Efficacy of puerarin in rats with focal cerebral ischemia through modulation of the SIRT1/HIF-1α/VEGF signaling pathway and its effect on synaptic plasticity" @default.
- W4367186136 cites W1964000580 @default.
- W4367186136 cites W2004679107 @default.
- W4367186136 cites W2067813055 @default.
- W4367186136 cites W2112505121 @default.
- W4367186136 cites W2132386106 @default.
- W4367186136 cites W2213369694 @default.
- W4367186136 cites W2231130871 @default.
- W4367186136 cites W2888641023 @default.
- W4367186136 cites W2889731020 @default.
- W4367186136 cites W2899624554 @default.
- W4367186136 cites W2900112088 @default.
- W4367186136 cites W2900509384 @default.
- W4367186136 cites W2974087886 @default.
- W4367186136 cites W2990308001 @default.
- W4367186136 cites W2991304024 @default.
- W4367186136 cites W3001780488 @default.
- W4367186136 cites W3005623045 @default.
- W4367186136 cites W3009556151 @default.
- W4367186136 cites W3083125992 @default.
- W4367186136 cites W3095516358 @default.
- W4367186136 cites W3096401852 @default.
- W4367186136 cites W3097256238 @default.
- W4367186136 cites W3109573151 @default.
- W4367186136 cites W3182268005 @default.
- W4367186136 cites W3185277097 @default.
- W4367186136 cites W3212242589 @default.
- W4367186136 doi "https://doi.org/10.1016/j.heliyon.2023.e15872" @default.
- W4367186136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37223716" @default.
- W4367186136 hasPublicationYear "2023" @default.
- W4367186136 type Work @default.
- W4367186136 citedByCount "0" @default.
- W4367186136 crossrefType "journal-article" @default.
- W4367186136 hasAuthorship W4367186136A5000510955 @default.
- W4367186136 hasAuthorship W4367186136A5016634509 @default.
- W4367186136 hasAuthorship W4367186136A5021687717 @default.
- W4367186136 hasAuthorship W4367186136A5038696969 @default.
- W4367186136 hasAuthorship W4367186136A5041005462 @default.
- W4367186136 hasBestOaLocation W43671861361 @default.
- W4367186136 hasConcept C126322002 @default.
- W4367186136 hasConcept C134018914 @default.
- W4367186136 hasConcept C142724271 @default.
- W4367186136 hasConcept C167734588 @default.
- W4367186136 hasConcept C169760540 @default.
- W4367186136 hasConcept C170493617 @default.
- W4367186136 hasConcept C187541742 @default.
- W4367186136 hasConcept C204232928 @default.
- W4367186136 hasConcept C204787440 @default.
- W4367186136 hasConcept C2777025900 @default.
- W4367186136 hasConcept C2777209535 @default.
- W4367186136 hasConcept C2778356392 @default.
- W4367186136 hasConcept C2778646069 @default.
- W4367186136 hasConcept C2778820722 @default.
- W4367186136 hasConcept C42219234 @default.
- W4367186136 hasConcept C541997718 @default.
- W4367186136 hasConcept C71924100 @default.
- W4367186136 hasConcept C86803240 @default.
- W4367186136 hasConcept C98229152 @default.
- W4367186136 hasConceptScore W4367186136C126322002 @default.
- W4367186136 hasConceptScore W4367186136C134018914 @default.
- W4367186136 hasConceptScore W4367186136C142724271 @default.
- W4367186136 hasConceptScore W4367186136C167734588 @default.
- W4367186136 hasConceptScore W4367186136C169760540 @default.
- W4367186136 hasConceptScore W4367186136C170493617 @default.
- W4367186136 hasConceptScore W4367186136C187541742 @default.
- W4367186136 hasConceptScore W4367186136C204232928 @default.
- W4367186136 hasConceptScore W4367186136C204787440 @default.
- W4367186136 hasConceptScore W4367186136C2777025900 @default.
- W4367186136 hasConceptScore W4367186136C2777209535 @default.
- W4367186136 hasConceptScore W4367186136C2778356392 @default.
- W4367186136 hasConceptScore W4367186136C2778646069 @default.
- W4367186136 hasConceptScore W4367186136C2778820722 @default.
- W4367186136 hasConceptScore W4367186136C42219234 @default.
- W4367186136 hasConceptScore W4367186136C541997718 @default.
- W4367186136 hasConceptScore W4367186136C71924100 @default.
- W4367186136 hasConceptScore W4367186136C86803240 @default.
- W4367186136 hasConceptScore W4367186136C98229152 @default.
- W4367186136 hasIssue "5" @default.
- W4367186136 hasLocation W43671861361 @default.
- W4367186136 hasLocation W43671861362 @default.
- W4367186136 hasLocation W43671861363 @default.
- W4367186136 hasOpenAccess W4367186136 @default.
- W4367186136 hasPrimaryLocation W43671861361 @default.
- W4367186136 hasRelatedWork W1975174814 @default.
- W4367186136 hasRelatedWork W1982371864 @default.
- W4367186136 hasRelatedWork W2039496891 @default.
- W4367186136 hasRelatedWork W2396486584 @default.
- W4367186136 hasRelatedWork W2575375033 @default.
- W4367186136 hasRelatedWork W2947198237 @default.