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- W4367186358 abstract "Human milk fatty acids derive from maternal diet, body stores, and mammary synthesis and may be influenced by women’s underlying cardiometabolic health. We explored whether milk fatty acid composition was associated with maternal cardiometabolic disease (CMD) during pregnancy and up to 5 years postpartum. We analyzed data from the prospective CHILD Cohort Study on 1,018 women with no pre-existing CMD who provided breast milk samples at 3-4 months postpartum. Milk fatty acids were measured using gas liquid chromatography. Maternal CMD (diabetes or hypertension) was classified using questionnaires and birth records as: no CMD (reference outcome group; 81.1%), perinatal CMD (developed and resolved during the perinatal period; 14.9%), persistent CMD (developed during and persisted beyond the perinatal period; 2.9%), or incident CMD (developed after the perinatal period; 1.1%). Multinomial logistic regression was used to model associations between milk fatty acid composition (individual, summary, ratios, and patterns identified using principal component analysis) and maternal CMD, adjusting for pre-pregnancy anthropometry and race/ethnicity. Medium-chain saturated fatty acids (MC-SFA), lauric (OR=0.73, 95% CI=0.60–0.89) and myristic acid (OR=0.80, 95% CI=0.66–0.97), and the high MC-SFA pattern (OR=0.86, 95% CI=0.76–0.96) were inversely associated with perinatal CMD. Long-chain polyunsaturated fatty acid adrenic acid was positively associated with perinatal (OR=1.21, 95% CI=1.01–1.44) and persistent CMD (OR=1.56, 95% CI=1.08–2.25). The arachidonic acid-to-docosahexaenoic acid ratio was inversely associated with incident CMD (OR=0.52, 95% CI=0.28–0.96). These exploratory findings highlight a potential novel utility of breast milk for understanding women’s cardiometabolic health." @default.
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- W4367186358 date "2023-05-01" @default.
- W4367186358 modified "2023-09-25" @default.
- W4367186358 title "Association of Human Milk Fatty Acid Composition with Maternal Cardiometabolic Diseases: An Exploratory Prospective Cohort Study" @default.
- W4367186358 doi "https://doi.org/10.1016/j.cjca.2023.02.030" @default.
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