FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367187079> ?p ?o ?g. }

• W4367187079 endingPage "122136" @default.
• W4367187079 startingPage "122136" @default.
• W4367187079 abstract "Regional metastasis of head and neck cancer (HNC) is prevalent (approximately 50% of patients at diagnosis), yet the underlying drivers and mechanisms of lymphatic spread remain unclear. The complex tumor microenvironment (TME) of HNC plays a crucial role in disease maintenance and progression; however, the contribution of the lymphatics remains underexplored. We created a primary patient cell derived microphysiological system that incorporates cancer-associated-fibroblasts from patients with HNC alongside a HNC tumor spheroid and a lymphatic microvessel to create an in vitro TME platform to investigate metastasis. Screening of soluble factor signaling identified novel secretion of macrophage migration inhibitory factor (MIF) by lymphatic endothelial cells conditioned in the TME. Importantly, we also observed patient-to-patient heterogeneity in cancer cell migration similar to the heterogeneity observed in clinical disease. Optical metabolic imaging at the single cell level identified a distinct metabolic profile of migratory versus non-migratory HNC cells in a microenvironment dependent manner. Additionally, we report a unique role of MIF in increasing HNC reliance on glycolysis over oxidative phosphorylation. This multicellular, microfluidic platform expands the tools available to explore HNC biology in vitro through multiple orthogonal outputs and establishes a system with enough resolution to visualize and quantify patient-to-patient heterogeneity." @default.
• W4367187079 created "2023-04-28" @default.
• W4367187079 creator A5000590503 @default.
• W4367187079 creator A5001024092 @default.
• W4367187079 creator A5014133933 @default.
• W4367187079 creator A5049773860 @default.
• W4367187079 creator A5054078149 @default.
• W4367187079 creator A5056957750 @default.
• W4367187079 creator A5080856494 @default.
• W4367187079 creator A5084628898 @default.
• W4367187079 date "2023-07-01" @default.
• W4367187079 modified "2023-09-29" @default.
• W4367187079 title "Microphysiological head and neck cancer model identifies novel role of lymphatically secreted monocyte migration inhibitory factor in cancer cell migration and metabolism" @default.
• W4367187079 cites W1508618954 @default.
• W4367187079 cites W1540077618 @default.
• W4367187079 cites W1583958653 @default.
• W4367187079 cites W1683381145 @default.
• W4367187079 cites W1892152977 @default.
• W4367187079 cites W1944951884 @default.
• W4367187079 cites W1966913795 @default.
• W4367187079 cites W1967062775 @default.
• W4367187079 cites W1983783590 @default.
• W4367187079 cites W1986255777 @default.
• W4367187079 cites W1990956554 @default.
• W4367187079 cites W1991922050 @default.
• W4367187079 cites W2010922778 @default.
• W4367187079 cites W2022185889 @default.
• W4367187079 cites W2022835736 @default.
• W4367187079 cites W2051505604 @default.
• W4367187079 cites W2071867803 @default.
• W4367187079 cites W2086995300 @default.
• W4367187079 cites W2111920179 @default.
• W4367187079 cites W2115298350 @default.
• W4367187079 cites W2121388227 @default.
• W4367187079 cites W2126116350 @default.
• W4367187079 cites W2126405914 @default.
• W4367187079 cites W2129827453 @default.
• W4367187079 cites W2144602805 @default.
• W4367187079 cites W2147793640 @default.
• W4367187079 cites W2167279371 @default.
• W4367187079 cites W2178070127 @default.
• W4367187079 cites W2251072051 @default.
• W4367187079 cites W2395626624 @default.
• W4367187079 cites W2537739770 @default.
• W4367187079 cites W2604318464 @default.
• W4367187079 cites W2625525216 @default.
• W4367187079 cites W2770871597 @default.
• W4367187079 cites W2792988832 @default.
• W4367187079 cites W2793035160 @default.
• W4367187079 cites W2806277779 @default.
• W4367187079 cites W2899763802 @default.
• W4367187079 cites W2904634758 @default.
• W4367187079 cites W2909132458 @default.
• W4367187079 cites W2912525330 @default.
• W4367187079 cites W2920318548 @default.
• W4367187079 cites W2937861116 @default.
• W4367187079 cites W2939560267 @default.
• W4367187079 cites W2945192934 @default.
• W4367187079 cites W2948287839 @default.
• W4367187079 cites W2997271239 @default.
• W4367187079 cites W3017030871 @default.
• W4367187079 cites W3023106176 @default.
• W4367187079 cites W3030219438 @default.
• W4367187079 cites W3092970695 @default.
• W4367187079 cites W3114119064 @default.
• W4367187079 cites W3119005666 @default.
• W4367187079 cites W3121611509 @default.
• W4367187079 cites W3128844369 @default.
• W4367187079 cites W3156552383 @default.
• W4367187079 cites W3158724419 @default.
• W4367187079 cites W3206685614 @default.
• W4367187079 cites W4220965805 @default.
• W4367187079 cites W4226141710 @default.
• W4367187079 cites W4281761004 @default.
• W4367187079 doi "https://doi.org/10.1016/j.biomaterials.2023.122136" @default.
• W4367187079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37178589" @default.
• W4367187079 hasPublicationYear "2023" @default.
• W4367187079 type Work @default.
• W4367187079 citedByCount "0" @default.
• W4367187079 crossrefType "journal-article" @default.
• W4367187079 hasAuthorship W4367187079A5000590503 @default.
• W4367187079 hasAuthorship W4367187079A5001024092 @default.
• W4367187079 hasAuthorship W4367187079A5014133933 @default.
• W4367187079 hasAuthorship W4367187079A5049773860 @default.
• W4367187079 hasAuthorship W4367187079A5054078149 @default.
• W4367187079 hasAuthorship W4367187079A5056957750 @default.
• W4367187079 hasAuthorship W4367187079A5080856494 @default.
• W4367187079 hasAuthorship W4367187079A5084628898 @default.
• W4367187079 hasConcept C104177226 @default.
• W4367187079 hasConcept C121608353 @default.
• W4367187079 hasConcept C126322002 @default.
• W4367187079 hasConcept C137738243 @default.
• W4367187079 hasConcept C1491633281 @default.
• W4367187079 hasConcept C181152851 @default.
• W4367187079 hasConcept C203014093 @default.
• W4367187079 hasConcept C2776107976 @default.
• W4367187079 hasConcept C2776530083 @default.
• W4367187079 hasConcept C2776833033 @default.

• next