Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367187462> ?p ?o ?g. }
- W4367187462 endingPage "414.e2" @default.
- W4367187462 startingPage "400" @default.
- W4367187462 abstract "Tobramycin (TOB) exhibits variable pharmacokinetic properties due to the clinical condition of patients. This study aimed to investigate the AUC-guided dosing of TOB based on population pharmacokinetic analysis in the treatment of infections caused by Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia.This retrospective study was conducted between January 2010 and December 2020 after obtaining approval from our institutional review board. For 53 patients who received therapeutic drug monitoring of TOB, a population pharmacokinetic model was developed with covariates of estimated glomerular filtration rate using serum creatinine (eGFRcre) on clearance (CL) and weight on both CL and Vd in exponential error modeling (CL = 2.84 × [weight/70] × eGFRcre0.568, interindividual variability [IIV] = 31.1%; Vd = 26.3 × [weight/70], IIV = 20.2%; residual variability = 28.8%).The final regression model for predicting 30-day mortality was developed with risk factors of AUC during a 24-hour period after the first dose to MIC ratio (odds ratio [OR] = 0.996; 95% CI, 0.968-1.003) and serum albumin (OR = 0.137; 95% CI, 0.022-0.632). The final regression model for predicting acute kidney injury was developed with the risk factors of C-reactive protein (OR = 1.136; 95% CI, 1.040-1.266) and AUC during a 72-hour period after the first dose (OR = 1.004; 95% CI, 1.000-1.001). A dose of 8 or 15 mg/kg was beneficial for achievement of AUC during a 24-hour period after the first dose/MIC >80 and trough concentration <1 µg/mL in patients with preserved kidney function and TOB CL >4.47 L/h/70 kg in the events of MIC of 1 or 2 µg/mL, respectively. We propose that the first dose of 15, 11, 10, 8, and 7 mg/kg for eGFRcre >90, 60 to 89, 45 to 59, 30 to 44, and 15 to 29 mL/min/1.73 m2 be followed by therapeutic drug monitoring at peak and 24 hours after the first dose.This study suggests that TOB use encourages the replacement of trough- and peak-targeted dosing with AUC-guided dosing." @default.
- W4367187462 created "2023-04-28" @default.
- W4367187462 creator A5010918379 @default.
- W4367187462 creator A5039137137 @default.
- W4367187462 creator A5057923441 @default.
- W4367187462 creator A5061450565 @default.
- W4367187462 creator A5066355089 @default.
- W4367187462 date "2023-05-01" @default.
- W4367187462 modified "2023-09-27" @default.
- W4367187462 title "Population Pharmacokinetics and AUC-Guided Dosing of Tobramycin in the Treatment of Infections Caused by Glucose-Nonfermenting Gram-Negative Bacteria" @default.
- W4367187462 cites W1921056904 @default.
- W4367187462 cites W1950543547 @default.
- W4367187462 cites W1965479467 @default.
- W4367187462 cites W1972313504 @default.
- W4367187462 cites W1974826069 @default.
- W4367187462 cites W1988114782 @default.
- W4367187462 cites W2004026051 @default.
- W4367187462 cites W2011719960 @default.
- W4367187462 cites W2018125671 @default.
- W4367187462 cites W2026274122 @default.
- W4367187462 cites W2057101877 @default.
- W4367187462 cites W2063111478 @default.
- W4367187462 cites W2066241879 @default.
- W4367187462 cites W2073742622 @default.
- W4367187462 cites W2076306411 @default.
- W4367187462 cites W2090581372 @default.
- W4367187462 cites W2090750145 @default.
- W4367187462 cites W2097945561 @default.
- W4367187462 cites W2110424949 @default.
- W4367187462 cites W2110991941 @default.
- W4367187462 cites W2114123644 @default.
- W4367187462 cites W2124791110 @default.
- W4367187462 cites W2125417606 @default.
- W4367187462 cites W2131824057 @default.
- W4367187462 cites W2138712728 @default.
- W4367187462 cites W2142447850 @default.
- W4367187462 cites W2149186506 @default.
- W4367187462 cites W2149772238 @default.
- W4367187462 cites W2152189242 @default.
- W4367187462 cites W2153615679 @default.
- W4367187462 cites W2155681864 @default.
- W4367187462 cites W2167676776 @default.
- W4367187462 cites W2337544276 @default.
- W4367187462 cites W2587355458 @default.
- W4367187462 cites W2681190354 @default.
- W4367187462 cites W2765631041 @default.
- W4367187462 cites W2806092108 @default.
- W4367187462 cites W2900159876 @default.
- W4367187462 cites W2943847872 @default.
- W4367187462 cites W2970103499 @default.
- W4367187462 cites W3022327571 @default.
- W4367187462 cites W3046685440 @default.
- W4367187462 cites W3068359810 @default.
- W4367187462 cites W3085917842 @default.
- W4367187462 cites W3087589362 @default.
- W4367187462 cites W3092492681 @default.
- W4367187462 cites W3092783549 @default.
- W4367187462 cites W3126910175 @default.
- W4367187462 cites W3129921430 @default.
- W4367187462 cites W3152567849 @default.
- W4367187462 cites W3154042781 @default.
- W4367187462 cites W3159459052 @default.
- W4367187462 cites W3160019729 @default.
- W4367187462 cites W3167226405 @default.
- W4367187462 cites W3172220916 @default.
- W4367187462 cites W3185297652 @default.
- W4367187462 cites W3192527513 @default.
- W4367187462 cites W3215663450 @default.
- W4367187462 cites W4200022531 @default.
- W4367187462 cites W4211144975 @default.
- W4367187462 cites W4220862783 @default.
- W4367187462 cites W4315646833 @default.
- W4367187462 doi "https://doi.org/10.1016/j.clinthera.2023.03.015" @default.
- W4367187462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37120413" @default.
- W4367187462 hasPublicationYear "2023" @default.
- W4367187462 type Work @default.
- W4367187462 citedByCount "0" @default.
- W4367187462 crossrefType "journal-article" @default.
- W4367187462 hasAuthorship W4367187462A5010918379 @default.
- W4367187462 hasAuthorship W4367187462A5039137137 @default.
- W4367187462 hasAuthorship W4367187462A5057923441 @default.
- W4367187462 hasAuthorship W4367187462A5061450565 @default.
- W4367187462 hasAuthorship W4367187462A5066355089 @default.
- W4367187462 hasConcept C112705442 @default.
- W4367187462 hasConcept C126322002 @default.
- W4367187462 hasConcept C159641895 @default.
- W4367187462 hasConcept C2775832221 @default.
- W4367187462 hasConcept C2777288759 @default.
- W4367187462 hasConcept C2778974779 @default.
- W4367187462 hasConcept C2780272996 @default.
- W4367187462 hasConcept C2908647359 @default.
- W4367187462 hasConcept C501593827 @default.
- W4367187462 hasConcept C71924100 @default.
- W4367187462 hasConcept C86803240 @default.
- W4367187462 hasConcept C89423630 @default.
- W4367187462 hasConcept C98274493 @default.
- W4367187462 hasConcept C99454951 @default.
- W4367187462 hasConceptScore W4367187462C112705442 @default.