Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367187597> ?p ?o ?g. }
- W4367187597 abstract "Abstract Glycans are an essential structural component of Immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association studies (GWAS) identified 29 genomic regions involved in regulation of IgG glycosylation, but only a few were functionally validated. One of the key functional features of IgG glycosylation is the addition of galactose (galactosylation). We performed GWAS of IgG galactosylation (N=13,705) and identified 16 significantly associated loci, indicating that IgG galactosylation is regulated by a complex network of genes that extends beyond the galactosyltransferase enzyme that adds galactose to IgG glycans. Gene prioritization identified 37 candidate genes. Using a recently developed CRISPR/dCas9 system we manipulated gene expression of candidate genes in the in vitro IgG expression system. Up- and downregulation of three genes, EEF1A1, MANBA and TNFRSF13B , changed the IgG glycome composition, which confirmed that these three genes are involved in IgG galactosylation in this in vitro expression system." @default.
- W4367187597 created "2023-04-28" @default.
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- W4367187597 date "2023-04-27" @default.
- W4367187597 modified "2023-10-18" @default.
- W4367187597 title "Mapping of the gene network that regulates glycan clock of ageing" @default.
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