Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367276768> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4367276768 endingPage "A102" @default.
- W4367276768 startingPage "A102" @default.
- W4367276768 abstract "Over 1 million Americans suffer from acute myocardial infarction (AMI) annually. Although mortality from AMI has decreased, post-AMI congestive heart failure is increasing due to microvascular obstruction (MVO). MVO comprises mechanical obstruction, along with oxidate stress and inflammation. Currently available treatments for MVO are not consistently effective. Hence, we have been developing ultrasound (US)-targeted microbubble cavitation (UTMC) as a potential treatment for MVO. Nitro-fatty acids (NFA) are pleiotropic signaling molecules with broad anti-inflammatory actions, potentially beneficial for the treatment of MVO. NFA are amphipathic thus can seamlessly integrate into the phospholipid shell of MBs. Thus, we have constructed microbubbles with NFA (NFABs) to treat ischemia-reperfusion injury (IRI) with UTMC in the rat myocardial model. Left anterior descending (LAD) coronary artery was ligated for 30 min, allowing for IRI. After 15 min of reperfusion, UTMC + NFABs therapy was administered. Echocardiography measurements were recorded at baseline, during ligation and post-treatment. Left ventricular fractional shortening (%) was calculated and NFA concentration in cardiac tissue was determined. UTMC with NFABs exhibited promising efficacy in improving fractional shortening post IRI, and in targeted myocardial delivery of NFA. Studies assessing ejection fraction, myocardial area at risk, histopathology, inflammatory burden, oxidative stress and cytoprotective biomarkers are underway." @default.
- W4367276768 created "2023-04-29" @default.
- W4367276768 creator A5007468650 @default.
- W4367276768 creator A5013958345 @default.
- W4367276768 creator A5015566121 @default.
- W4367276768 creator A5017169939 @default.
- W4367276768 creator A5038467192 @default.
- W4367276768 creator A5077714526 @default.
- W4367276768 creator A5086281831 @default.
- W4367276768 date "2023-03-01" @default.
- W4367276768 modified "2023-10-01" @default.
- W4367276768 title "Cardioprotective efficacy of ultrasound-targeted nitrofatty acid microbubbles in rat myocardial ischemia-reperfusion injury model" @default.
- W4367276768 doi "https://doi.org/10.1121/10.0018308" @default.
- W4367276768 hasPublicationYear "2023" @default.
- W4367276768 type Work @default.
- W4367276768 citedByCount "0" @default.
- W4367276768 crossrefType "journal-article" @default.
- W4367276768 hasAuthorship W4367276768A5007468650 @default.
- W4367276768 hasAuthorship W4367276768A5013958345 @default.
- W4367276768 hasAuthorship W4367276768A5015566121 @default.
- W4367276768 hasAuthorship W4367276768A5017169939 @default.
- W4367276768 hasAuthorship W4367276768A5038467192 @default.
- W4367276768 hasAuthorship W4367276768A5077714526 @default.
- W4367276768 hasAuthorship W4367276768A5086281831 @default.
- W4367276768 hasConcept C126322002 @default.
- W4367276768 hasConcept C126838900 @default.
- W4367276768 hasConcept C143753070 @default.
- W4367276768 hasConcept C164705383 @default.
- W4367276768 hasConcept C179437574 @default.
- W4367276768 hasConcept C2778198053 @default.
- W4367276768 hasConcept C2780114680 @default.
- W4367276768 hasConcept C500558357 @default.
- W4367276768 hasConcept C541997718 @default.
- W4367276768 hasConcept C64012434 @default.
- W4367276768 hasConcept C71924100 @default.
- W4367276768 hasConcept C78085059 @default.
- W4367276768 hasConceptScore W4367276768C126322002 @default.
- W4367276768 hasConceptScore W4367276768C126838900 @default.
- W4367276768 hasConceptScore W4367276768C143753070 @default.
- W4367276768 hasConceptScore W4367276768C164705383 @default.
- W4367276768 hasConceptScore W4367276768C179437574 @default.
- W4367276768 hasConceptScore W4367276768C2778198053 @default.
- W4367276768 hasConceptScore W4367276768C2780114680 @default.
- W4367276768 hasConceptScore W4367276768C500558357 @default.
- W4367276768 hasConceptScore W4367276768C541997718 @default.
- W4367276768 hasConceptScore W4367276768C64012434 @default.
- W4367276768 hasConceptScore W4367276768C71924100 @default.
- W4367276768 hasConceptScore W4367276768C78085059 @default.
- W4367276768 hasIssue "3_supplement" @default.
- W4367276768 hasLocation W43672767681 @default.
- W4367276768 hasOpenAccess W4367276768 @default.
- W4367276768 hasPrimaryLocation W43672767681 @default.
- W4367276768 hasRelatedWork W2045987832 @default.
- W4367276768 hasRelatedWork W2051712573 @default.
- W4367276768 hasRelatedWork W2077083067 @default.
- W4367276768 hasRelatedWork W2091139515 @default.
- W4367276768 hasRelatedWork W2319805938 @default.
- W4367276768 hasRelatedWork W2355594703 @default.
- W4367276768 hasRelatedWork W2999308310 @default.
- W4367276768 hasRelatedWork W3033076790 @default.
- W4367276768 hasRelatedWork W3155674270 @default.
- W4367276768 hasRelatedWork W3187572025 @default.
- W4367276768 hasVolume "153" @default.
- W4367276768 isParatext "false" @default.
- W4367276768 isRetracted "false" @default.
- W4367276768 workType "article" @default.