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• W4367285440 abstract "<sec> <title>BACKGROUND</title> Globally, most individuals who are susceptible to depression do not receive adequate or timely treatment. Unguided computerized cognitive behavioral therapy (cCBT) has the potential to bridge this treatment gap. However, the real-world effectiveness of unguided cCBT interventions, particularly in low- and middle-income countries (LMICs), remains inconclusive. </sec> <sec> <title>OBJECTIVE</title> In this study, we aimed to report the design and development of a new unguided cCBT–based multicomponent intervention, TreadWill, and its pragmatic evaluation. TreadWill was designed to be fully automated, engaging, easy to use, and accessible to LMICs. </sec> <sec> <title>METHODS</title> To evaluate the effectiveness of TreadWill and the engagement level, we performed a double-blind, fully remote, and randomized controlled trial with 598 participants in India and analyzed the data using a completer’s analysis. </sec> <sec> <title>RESULTS</title> The users who completed at least half of the modules in TreadWill showed significant reduction in depression-related (<i>P</i>=.04) and anxiety-related (<i>P</i>=.02) symptoms compared with the waitlist control. Compared with a plain-text version with the same therapeutic content, the full-featured version of TreadWill showed significantly higher engagement (<i>P=</i>.01). </sec> <sec> <title>CONCLUSIONS</title> Our study provides a new resource and evidence for the use of unguided cCBT as a scalable intervention in LMICs. </sec> <sec> <title>CLINICALTRIAL</title> ClinicalTrials.gov NCT03445598; https://clinicaltrials.gov/ct2/show/NCT03445598 </sec>" @default.
• W4367285440 created "2023-04-29" @default.
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• W4367285440 date "2022-07-12" @default.
• W4367285440 modified "2023-09-26" @default.
• W4367285440 title "An Unguided, Computerized Cognitive Behavioral Therapy Intervention (TreadWill) in a Lower Middle-Income Country: Pragmatic Randomized Controlled Trial (Preprint)" @default.
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• W4367285440 doi "https://doi.org/10.2196/preprints.41005" @default.
• W4367285440 hasPublicationYear "2022" @default.
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