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- W4367293203 abstract "Adult-born cells, arriving daily into the rodent olfactory bulb, either integrate into the neural circuitry or get eliminated. However, whether these two populations differ in their morphological or functional properties remains unclear. Using longitudinal in vivo two-photon imaging, we monitored dendritic morphogenesis, odor-evoked responsiveness, ongoing Ca2+ signaling, and survival/death of adult-born juxtaglomerular neurons (abJGNs). We found that the maturation of abJGNs is accompanied by a significant reduction in dendritic complexity, with surviving and subsequently eliminated cells showing similar degrees of dendritic remodeling. Surprisingly, ∼63% of eliminated abJGNs acquired odor responsiveness before death, with amplitudes and time courses of odor-evoked responses similar to those recorded in surviving cells. However, the subsequently eliminated cell population exhibited significantly higher ongoing Ca2+ signals, with a difference visible even 10 days before death. Quantitative supervised machine learning analysis revealed a relationship between the abJGNs’ activity and survival probability, with low neuronal activity being supportive for survival." @default.
- W4367293203 created "2023-04-29" @default.
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- W4367293203 date "2023-05-01" @default.
- W4367293203 modified "2023-10-01" @default.
- W4367293203 title "Neuronal silence as a prosurvival factor for adult-born olfactory bulb interneurons" @default.
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- W4367293203 doi "https://doi.org/10.1016/j.stemcr.2023.03.018" @default.
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