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• W4367293209 abstract "Aim of the study . To determine the effects of xenon exposure at a dose of 0.5 MAC of different duration on the content and enzyme-inactivating phosphorylation of the glycogen synthase kinase-3β (GSK3β) in the perifocal zone of ischemic cerebral infarction in an experimental setting. Materials and methods . The Long method was used for modelling brain ischemia/reperfusion in 39 rats weighing 300-350 g. Study group animals was exposed to xenon at a dose of 0.5 MAC during 30, 60 and 120 minutes whereas control group animals received an oxygen-air mixture. Sham-operated animals served as a comparison group. The levels of GSK3β and phospho-GSK3β in brain homogenates were determined by blotting using specific antibodies. Results . In ischemic stroke model, the content of GSK3β did not significantly change in control animals compared to comparison group. However, control group animals exhibited significant (2.7-fold, P <0.001) decrease in the content of its phospho-GSK3β in the perifocal zone of ischemic cerebral infarction. Inhalation of 0.5 MAC xenon during 30 minutes did not lead to an increase in phosphorylation of the GSK3β enzyme ( P =0.9), however, 60 and 120 minutes of 0.5 MAC xenon exposures resulted in the increase in phosphorylated form of the enzyme by a factor of 2.1 ( P =0.005) and 2.3 ( P =0.001), respectively, compared to the control group. Conclusion . The results reveal a possible molecular mechanism (i. e., execution of neuroprotective and anti-inflammatory effects of xenon due to GSK-Зβ inactivation) and show the prospects for using 60 and 120 minutes of 0.5 MAC xenon exposures in ischemic brain damage after a stroke, traumatic brain injury and other brain lesions." @default.
• W4367293209 created "2023-04-29" @default.
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• W4367293209 date "2023-04-26" @default.
• W4367293209 modified "2023-10-01" @default.
• W4367293209 title "The Effect of Xenon on the Activity of Glycogen Synthase Kinase-Зβ in the Perifocal Zone of Ischemic Cerebral Infarction (Experimental Study)" @default.
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• W4367293209 doi "https://doi.org/10.15360/1813-9779-2023-2-2274" @default.
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