Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367293759> ?p ?o ?g. }
- W4367293759 endingPage "100099" @default.
- W4367293759 startingPage "100099" @default.
- W4367293759 abstract "Heavy drinking can induce early-onset dementia and increase the likelihood of the progression and severity of Alzheimer's Disease and related dementias (ADRD). Recently, we showed that alcohol-drinking by mature adult C57BL/6J mice induces more signs of cognitive impairment in females versus males without worsening age-related cognitive decline in aged mice. Here, we immunoblotted for glutamate receptors and protein markers of ADRD-related neuropathology within the hippocampus and prefrontal cortex (PFC) of these mice after three weeks of alcohol withdrawal to determine protein correlates of alcohol-induced cognitive decline. Irrespective of alcohol history, age-related changes in protein expression included a male-specific decline in hippocampal glutamate receptors and an increase in the expression of a beta-site amyloid precursor protein cleaving enzyme (BACE) isoform in the PFC as well as a sex-independent increase in hippocampal amyloid precursor protein. Alcohol-drinking was associated with altered expression of glutamate receptors in the hippocampus in a sex-dependent manner, while all glutamate receptor proteins exhibited significant alcohol-related increases in the PFC of both sexes. Expression of BACE isoforms and phosphorylated tau varied in the PFC and hippocampus based on age, sex, and drinking history. The results of this study indicate that withdrawal from a history of alcohol-drinking during later life induces sex- and age-selective effects on glutamate receptor expression and protein markers of ADRD-related neuropathology within the hippocampus and PFC of potential relevance to the etiology, treatment and prevention of alcohol-induced dementia and Alzheimer's Disease." @default.
- W4367293759 created "2023-04-29" @default.
- W4367293759 creator A5002963814 @default.
- W4367293759 creator A5018962673 @default.
- W4367293759 creator A5024097076 @default.
- W4367293759 creator A5024630999 @default.
- W4367293759 creator A5026746860 @default.
- W4367293759 date "2023-09-01" @default.
- W4367293759 modified "2023-09-27" @default.
- W4367293759 title "Alcohol-drinking during later life by C57BL/6J mice induces sex- and age-dependent changes in hippocampal and prefrontal cortex expression of glutamate receptors and neuropathology markers" @default.
- W4367293759 cites W1051312076 @default.
- W4367293759 cites W144638589 @default.
- W4367293759 cites W1505997555 @default.
- W4367293759 cites W1524486546 @default.
- W4367293759 cites W1596984737 @default.
- W4367293759 cites W1738529902 @default.
- W4367293759 cites W193991277 @default.
- W4367293759 cites W1954244449 @default.
- W4367293759 cites W1963097925 @default.
- W4367293759 cites W1963556215 @default.
- W4367293759 cites W1964227372 @default.
- W4367293759 cites W1972033713 @default.
- W4367293759 cites W1977340092 @default.
- W4367293759 cites W1982313782 @default.
- W4367293759 cites W1983652754 @default.
- W4367293759 cites W1996831079 @default.
- W4367293759 cites W1998138099 @default.
- W4367293759 cites W2001752952 @default.
- W4367293759 cites W2003655335 @default.
- W4367293759 cites W2005915948 @default.
- W4367293759 cites W2007448929 @default.
- W4367293759 cites W2014016927 @default.
- W4367293759 cites W2015410192 @default.
- W4367293759 cites W2017956681 @default.
- W4367293759 cites W2022746377 @default.
- W4367293759 cites W2023041956 @default.
- W4367293759 cites W2032920422 @default.
- W4367293759 cites W2035528777 @default.
- W4367293759 cites W2036755018 @default.
- W4367293759 cites W2037875108 @default.
- W4367293759 cites W2044367989 @default.
- W4367293759 cites W2047869246 @default.
- W4367293759 cites W2052925957 @default.
- W4367293759 cites W2064609957 @default.
- W4367293759 cites W2065970134 @default.
- W4367293759 cites W2068888057 @default.
- W4367293759 cites W2069179155 @default.
- W4367293759 cites W2071068165 @default.
- W4367293759 cites W2076868543 @default.
- W4367293759 cites W2077943855 @default.
- W4367293759 cites W2090601883 @default.
- W4367293759 cites W2091094658 @default.
- W4367293759 cites W2093426751 @default.
- W4367293759 cites W2093872071 @default.
- W4367293759 cites W2095283153 @default.
- W4367293759 cites W2095367777 @default.
- W4367293759 cites W2097398649 @default.
- W4367293759 cites W2116298307 @default.
- W4367293759 cites W2118867129 @default.
- W4367293759 cites W2136860220 @default.
- W4367293759 cites W2136975483 @default.
- W4367293759 cites W2139893960 @default.
- W4367293759 cites W2140432027 @default.
- W4367293759 cites W2147889480 @default.
- W4367293759 cites W2155237226 @default.
- W4367293759 cites W2224588211 @default.
- W4367293759 cites W2395422150 @default.
- W4367293759 cites W2402958017 @default.
- W4367293759 cites W2521991649 @default.
- W4367293759 cites W2558817386 @default.
- W4367293759 cites W2560034663 @default.
- W4367293759 cites W2575824869 @default.
- W4367293759 cites W2613914741 @default.
- W4367293759 cites W2743968520 @default.
- W4367293759 cites W2779463443 @default.
- W4367293759 cites W2782408037 @default.
- W4367293759 cites W2790529391 @default.
- W4367293759 cites W2792063936 @default.
- W4367293759 cites W2792565886 @default.
- W4367293759 cites W2834941082 @default.
- W4367293759 cites W2886976326 @default.
- W4367293759 cites W2891243896 @default.
- W4367293759 cites W2903622567 @default.
- W4367293759 cites W2911406916 @default.
- W4367293759 cites W2911518850 @default.
- W4367293759 cites W2914644197 @default.
- W4367293759 cites W2952572679 @default.
- W4367293759 cites W2984858749 @default.
- W4367293759 cites W2985050537 @default.
- W4367293759 cites W2989784226 @default.
- W4367293759 cites W2996879041 @default.
- W4367293759 cites W3005941841 @default.
- W4367293759 cites W3014779409 @default.
- W4367293759 cites W3024260684 @default.
- W4367293759 cites W3037419297 @default.
- W4367293759 cites W3040785547 @default.
- W4367293759 cites W3048762992 @default.
- W4367293759 cites W3082616876 @default.