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- W4367293800 endingPage "106757" @default.
- W4367293800 startingPage "106757" @default.
- W4367293800 abstract "The complexity of the metazoan proteome is significantly increased by the expression of small proteins (<100 aa) derived from smORFs within lncRNAs, uORFs, 3′ UTRs and, reading frames overlapping the CDS. These smORF encoded proteins (SEPs) have diverse roles, ranging from the regulation of cellular physiological to essential developmental functions. We report the characterization of a new member of this protein family, SEP53BP1, derived from a small internal ORF that overlaps the CDS encoding 53BP1. Its expression is coupled to the utilization of an alternative, cell-type specific promoter coupled to translational reinitiation events mediated by a uORF in the alternative 5′ TL of the mRNA. This uORF-mediated reinitiation at an internal ORF is also observed in zebrafish. Interactome studies indicate that the human SEP53BP1 associates with components of the protein turnover pathway including the proteasome, and the TRiC/CCT chaperonin complex, suggesting that it may play a role in cellular proteostasis." @default.
- W4367293800 created "2023-04-29" @default.
- W4367293800 creator A5013082040 @default.
- W4367293800 creator A5026647731 @default.
- W4367293800 creator A5058819460 @default.
- W4367293800 creator A5063446181 @default.
- W4367293800 creator A5069443690 @default.
- W4367293800 creator A5086956108 @default.
- W4367293800 date "2023-05-01" @default.
- W4367293800 modified "2023-09-27" @default.
- W4367293800 title "TP53BP1, a dual-coding gene, uses promoter switching and translational reinitiation to express a smORF protein" @default.
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