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- W4367294014 abstract "In this month’s issue of the JAAD, Elewski et al (page 36) discuss a randomized, placebo-controlled study demonstrating rapid and sustained improvements in generalized pustular psoriasis flares with spesolimab. This valuable new agent promises to be a true game changer for pustular variants of psoriasis and other neutrophil-mediated disorders. Also in this issue, Gong et al (page 45) report on apolipoprotein A-IV as a novel predictor of prognosis in Stevens-Johnson syndrome/toxic epidermal necrolysis. The authors sought to assess the efficacy and safety of combination treatment with the tumor necrosis factor-alfa antagonist adalimumab and corticosteroids. Combination therapy shortened the time to mucocutaneous reepithelialization and healing, with fewer side effects caused by corticosteroids. Plasma proteomic profiling demonstrated that apolipoprotein A-IV was one of the most significant differentially expressed proteins and multivariate regression analysis revealed an association with prognosis. Limitations included the size of the cohort." @default.
- W4367294014 created "2023-04-29" @default.
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- W4367294014 date "2023-07-01" @default.
- W4367294014 modified "2023-09-23" @default.
- W4367294014 title "This month in JAAD: July 2023" @default.
- W4367294014 doi "https://doi.org/10.1016/j.jaad.2023.04.036" @default.
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