Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367295967> ?p ?o ?g. }
- W4367295967 endingPage "106767" @default.
- W4367295967 startingPage "106767" @default.
- W4367295967 abstract "Living cells process information about their environment through the central dogma processes of transcription and translation, which drive the cellular response to stimuli. Here, we study the transfer of information from environmental input to the transcript and protein expression levels. Evaluation of both experimental and analogous simulation data reveals that transcription and translation are not two simple information channels connected in series. Instead, we demonstrate that the central dogma reactions often create a time-integrating information channel, where the translation channel receives and integrates multiple outputs from the transcription channel. This information channel model of the central dogma provides new information-theoretic selection criteria for the central dogma rate constants. Using the data for four well-studied species we show that their central dogma rate constants achieve information gain because of time integration while also keeping the loss because of stochasticity in translation relatively low (<0.5 bits)." @default.
- W4367295967 created "2023-04-29" @default.
- W4367295967 creator A5072773241 @default.
- W4367295967 creator A5080411857 @default.
- W4367295967 date "2023-06-01" @default.
- W4367295967 modified "2023-10-18" @default.
- W4367295967 title "Nearly maximal information gain due to time integration in central dogma reactions" @default.
- W4367295967 cites W1508225465 @default.
- W4367295967 cites W1966054814 @default.
- W4367295967 cites W1983388907 @default.
- W4367295967 cites W1985161570 @default.
- W4367295967 cites W1987127255 @default.
- W4367295967 cites W2010173857 @default.
- W4367295967 cites W2018256109 @default.
- W4367295967 cites W2019472515 @default.
- W4367295967 cites W2021058886 @default.
- W4367295967 cites W2021387539 @default.
- W4367295967 cites W2023566618 @default.
- W4367295967 cites W2027657888 @default.
- W4367295967 cites W2041238782 @default.
- W4367295967 cites W2051342143 @default.
- W4367295967 cites W2052796757 @default.
- W4367295967 cites W2055214702 @default.
- W4367295967 cites W2059053384 @default.
- W4367295967 cites W2068872007 @default.
- W4367295967 cites W2071214852 @default.
- W4367295967 cites W2074489745 @default.
- W4367295967 cites W2075099666 @default.
- W4367295967 cites W2075251971 @default.
- W4367295967 cites W2076695023 @default.
- W4367295967 cites W2080433169 @default.
- W4367295967 cites W2096025479 @default.
- W4367295967 cites W2099139235 @default.
- W4367295967 cites W2109281577 @default.
- W4367295967 cites W2112326910 @default.
- W4367295967 cites W2120695614 @default.
- W4367295967 cites W2122121413 @default.
- W4367295967 cites W2128551987 @default.
- W4367295967 cites W2134440848 @default.
- W4367295967 cites W2134964128 @default.
- W4367295967 cites W2139122199 @default.
- W4367295967 cites W2139500219 @default.
- W4367295967 cites W2148986322 @default.
- W4367295967 cites W2167949116 @default.
- W4367295967 cites W2168571551 @default.
- W4367295967 cites W2171948041 @default.
- W4367295967 cites W2219121760 @default.
- W4367295967 cites W2329248684 @default.
- W4367295967 cites W2341244875 @default.
- W4367295967 cites W2524240402 @default.
- W4367295967 cites W2569268737 @default.
- W4367295967 cites W2613783344 @default.
- W4367295967 cites W2755050428 @default.
- W4367295967 cites W2757705619 @default.
- W4367295967 cites W2770907192 @default.
- W4367295967 cites W2772107495 @default.
- W4367295967 cites W2773585372 @default.
- W4367295967 cites W2809899191 @default.
- W4367295967 cites W2909620196 @default.
- W4367295967 cites W2909818156 @default.
- W4367295967 cites W2953166597 @default.
- W4367295967 cites W3020873672 @default.
- W4367295967 cites W3025476696 @default.
- W4367295967 cites W3119546074 @default.
- W4367295967 cites W3128046355 @default.
- W4367295967 cites W3165265242 @default.
- W4367295967 cites W4290994039 @default.
- W4367295967 doi "https://doi.org/10.1016/j.isci.2023.106767" @default.
- W4367295967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37235057" @default.
- W4367295967 hasPublicationYear "2023" @default.
- W4367295967 type Work @default.
- W4367295967 citedByCount "0" @default.
- W4367295967 crossrefType "journal-article" @default.
- W4367295967 hasAuthorship W4367295967A5072773241 @default.
- W4367295967 hasAuthorship W4367295967A5080411857 @default.
- W4367295967 hasBestOaLocation W43672959671 @default.
- W4367295967 hasConcept C104317684 @default.
- W4367295967 hasConcept C105580179 @default.
- W4367295967 hasConcept C127162648 @default.
- W4367295967 hasConcept C138885662 @default.
- W4367295967 hasConcept C149364088 @default.
- W4367295967 hasConcept C169760540 @default.
- W4367295967 hasConcept C179926584 @default.
- W4367295967 hasConcept C185592680 @default.
- W4367295967 hasConcept C31258907 @default.
- W4367295967 hasConcept C41008148 @default.
- W4367295967 hasConcept C41895202 @default.
- W4367295967 hasConcept C54355233 @default.
- W4367295967 hasConcept C70721500 @default.
- W4367295967 hasConcept C76155785 @default.
- W4367295967 hasConcept C86803240 @default.
- W4367295967 hasConcept C8854915 @default.
- W4367295967 hasConceptScore W4367295967C104317684 @default.
- W4367295967 hasConceptScore W4367295967C105580179 @default.
- W4367295967 hasConceptScore W4367295967C127162648 @default.
- W4367295967 hasConceptScore W4367295967C138885662 @default.
- W4367295967 hasConceptScore W4367295967C149364088 @default.
- W4367295967 hasConceptScore W4367295967C169760540 @default.