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• W4367296054 abstract "Methylphenidate (MPH) and methamphetamine (METH) are the current treatments of choice for attention deficit/hyperactivity disorder. We previously reported that METH induces the release of dopamine (DA) and of the neurotransmitter candidate L-3,4-dihydroxyphenylalanine (L-DOPA). In contrast, we here found that MPH increased the DA release while it did not affect the L-DOPA release from the dorsolateral striatum. Nevertheless, MPH-induced hyperlocomotion was reduced in Gpr143 (L-DOPA receptor) gene-deficient (Gpr143−/y) mice. The rewarding effect and increased c-fos expression induced by MPH were also attenuated in Gpr143−/y mice. Together, these findings suggest that GPR143 is involved in the acute and chronic actions of MPH." @default.
• W4367296054 created "2023-04-29" @default.
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• W4367296054 date "2023-07-01" @default.
• W4367296054 modified "2023-10-14" @default.
• W4367296054 title "Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate" @default.
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• W4367296054 doi "https://doi.org/10.1016/j.jphs.2023.04.006" @default.
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