FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367296069> ?p ?o ?g. }

• W4367296069 abstract "<h3>Objective:</h3> To evaluate the relationship between lesion location, functional systems, and disability using an artificial intelligence (AI) model. <h3>Background:</h3> The topographical model of MS depicts localized lesion burden in a pool of variable neurological reserve, with the cervical cord at the shallow end. <h3>Design/Methods:</h3> 63 people with MS (30 RRMS, 33 SPMS, 51 female, baseline age 45.8±10.0 yrs) were longitudinally evaluated with MRI and clinical metrics (EDSS and functional system scores [FSS]) with median 2 time points, max. 8, (total: 154), follow-up 2.1±2.5 years. Imaging: icobrain was used to measure T2-FLAIR lesions on brain MRI, and adapted to measure T2 lesion volumes in cervical cord. To create a lesion/reserve ratio, localized lesion volume percentiles were divided by regional parenchymal volume percentile (cerebral, infratentorial, cervical cord), yielding regionally-specific lesion parenchymal fraction (LPF). Modeling: in 500 iterations, Random Forest (RF) regression models were trained to estimate cross-sectional EDSS and FSS. Estimations were Spearman correlated with actual scores; median correlation was assessed. To evaluate role of LPF, two estimator sets were used: 1) simple model: age and sex, 2) full model: age, sex, and topographical LPF. <h3>Results:</h3> Spearman correlations between fitted and true clinical scores were highest for overall EDSS (R=0.29), pyramidal (R=0.37), bowel/bladder (R=0.38), and cerebellar (R=0.27). Models including LPF outperformed the simple model in 100%, 100%, 98%, and 91% of iterations, respectively. The EDSS and pyramidal FSS were most strongly associated with infratentorial LPF, which also most strongly predicted conversion to SPMS. <h3>Conclusions:</h3> Lesion localization can be mapped to specific functional systems to explicate MS heterogeneity. Lesion parenchymal fraction, an assessment of lesion load/parenchymal volume ratio, is a quantified expression of the topographical model of MS and may be a useful MRI correlate of MS clinical symptoms. Using this metric, AI techniques can be refined to identify specific thresholds for conversion to SPMS. <b>Disclosure:</b> Dr. Krieger has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Krieger has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for EMD Serono. Dr. Krieger has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech. Dr. Krieger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Dr. Krieger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for TG Therapeutics. Dr. Krieger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Krieger has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Expert Witness. The institution of Dr. Krieger has received research support from Novartis. The institution of Dr. Krieger has received research support from Bristol Myers Squibb. Thibo Billiet has received personal compensation for serving as an employee of icometrix. Miss Maes has received personal compensation for serving as an employee of icometrix. Dr. De Barros has received personal compensation for serving as an employee of Icometrix. Dr. Van Hecke has received personal compensation for serving as an employee of icometrix. Annemie Ribbens, 9599 has received personal compensation for serving as an employee of icometrix. Annemie Ribbens, 9599 has stock in icometrix. Chenyu Wang, 7886 has received personal compensation for serving as an employee of Sydney Neuroimaging Analysis Centre. The institution of Chenyu Wang, 7886 has received research support from Multiple Sclerosis Research Australia. Kain Kyle has received personal compensation for serving as an employee of Sydney Neuroimaging Analysis Centre. Kain Kyle has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sydney Neuroimaging Analysis Centre. Linda Ly has nothing to disclose. Dr. Garber has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Garber has received research support from Trish MS Foundation. Michael Barnett has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sydney Neuroimaging Analysis Centre. An immediate family member of Michael Barnett has received stock or an ownership interest from RxMx. The institution of Michael Barnett has received research support from Genzyme Sanofi. The institution of Michael Barnett has received research support from Biogen. The institution of Michael Barnett has received research support from Novartis." @default.
• W4367296069 created "2023-04-29" @default.
• W4367296069 creator A5001679084 @default.
• W4367296069 creator A5003895017 @default.
• W4367296069 creator A5029371783 @default.
• W4367296069 creator A5033877964 @default.
• W4367296069 creator A5034242696 @default.
• W4367296069 creator A5036128004 @default.
• W4367296069 creator A5061402319 @default.
• W4367296069 creator A5079698055 @default.
• W4367296069 creator A5079965425 @default.
• W4367296069 creator A5082119673 @default.
• W4367296069 creator A5086329561 @default.
• W4367296069 date "2023-04-25" @default.
• W4367296069 modified "2023-09-30" @default.
• W4367296069 title "AI-based characterization of multiple sclerosis clinical symptomatology using lesion parenchymal fraction: empirical support for the topographical model of MS (P3-3.018)" @default.
• W4367296069 doi "https://doi.org/10.1212/wnl.0000000000202986" @default.
• W4367296069 hasPublicationYear "2023" @default.
• W4367296069 type Work @default.
• W4367296069 citedByCount "0" @default.
• W4367296069 crossrefType "proceedings-article" @default.
• W4367296069 hasAuthorship W4367296069A5001679084 @default.
• W4367296069 hasAuthorship W4367296069A5003895017 @default.
• W4367296069 hasAuthorship W4367296069A5029371783 @default.
• W4367296069 hasAuthorship W4367296069A5033877964 @default.
• W4367296069 hasAuthorship W4367296069A5034242696 @default.
• W4367296069 hasAuthorship W4367296069A5036128004 @default.
• W4367296069 hasAuthorship W4367296069A5061402319 @default.
• W4367296069 hasAuthorship W4367296069A5079698055 @default.
• W4367296069 hasAuthorship W4367296069A5079965425 @default.
• W4367296069 hasAuthorship W4367296069A5082119673 @default.
• W4367296069 hasAuthorship W4367296069A5086329561 @default.
• W4367296069 hasConcept C101070640 @default.
• W4367296069 hasConcept C105795698 @default.
• W4367296069 hasConcept C118552586 @default.
• W4367296069 hasConcept C122048520 @default.
• W4367296069 hasConcept C126322002 @default.
• W4367296069 hasConcept C126838900 @default.
• W4367296069 hasConcept C142724271 @default.
• W4367296069 hasConcept C143409427 @default.
• W4367296069 hasConcept C2780640218 @default.
• W4367296069 hasConcept C2781156865 @default.
• W4367296069 hasConcept C2989005 @default.
• W4367296069 hasConcept C33923547 @default.
• W4367296069 hasConcept C71924100 @default.
• W4367296069 hasConceptScore W4367296069C101070640 @default.
• W4367296069 hasConceptScore W4367296069C105795698 @default.
• W4367296069 hasConceptScore W4367296069C118552586 @default.
• W4367296069 hasConceptScore W4367296069C122048520 @default.
• W4367296069 hasConceptScore W4367296069C126322002 @default.
• W4367296069 hasConceptScore W4367296069C126838900 @default.
• W4367296069 hasConceptScore W4367296069C142724271 @default.
• W4367296069 hasConceptScore W4367296069C143409427 @default.
• W4367296069 hasConceptScore W4367296069C2780640218 @default.
• W4367296069 hasConceptScore W4367296069C2781156865 @default.
• W4367296069 hasConceptScore W4367296069C2989005 @default.
• W4367296069 hasConceptScore W4367296069C33923547 @default.
• W4367296069 hasConceptScore W4367296069C71924100 @default.
• W4367296069 hasLocation W43672960691 @default.
• W4367296069 hasOpenAccess W4367296069 @default.
• W4367296069 hasPrimaryLocation W43672960691 @default.
• W4367296069 hasRelatedWork W2001364525 @default.
• W4367296069 hasRelatedWork W2005020945 @default.
• W4367296069 hasRelatedWork W2041543008 @default.
• W4367296069 hasRelatedWork W2056919748 @default.
• W4367296069 hasRelatedWork W2062532180 @default.
• W4367296069 hasRelatedWork W2165532981 @default.
• W4367296069 hasRelatedWork W2180241394 @default.
• W4367296069 hasRelatedWork W2365219015 @default.
• W4367296069 hasRelatedWork W2395410554 @default.
• W4367296069 hasRelatedWork W2400349113 @default.
• W4367296069 isParatext "false" @default.
• W4367296069 isRetracted "false" @default.
• W4367296069 workType "article" @default.