FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367296444> ?p ?o ?g. }

• W4367296444 endingPage "6943" @default.
• W4367296444 startingPage "6935" @default.
• W4367296444 abstract "Pentacyclic triterpenoids, including betulinic acid (BA), and their glycosides are abundant in fruits such as Zizyphus sp., Dillenia sp., and Azanza sp. These compounds exhibit various pharmacological activities in human cells. Here, we investigated the effects of BA on the cellular proliferation and senescence of cultured normal human dermal fibroblasts (NHDFs). BA treatment for 24–48 h increased the proliferation of low-passage young fibroblasts. Furthermore, BA reduced the proportion of senescent cells, as determined via the β-galactosidase assay of high-passage NHDFs. DNA microarray analysis and subsequent validations via quantitative real-time polymerase chain reaction revealed that BA downregulates interferon (IFN)-inducible genes, including IFIT1, IFITM1, IFI6, MX1, and OAS2, which are upregulated in replicative senescent cells compared with the low-passage young cells (control). Enrichment analysis based on the microarray data predicted BA-induced suppression of the type I IFN signaling pathway. BA downregulated the expression of the IRF9 transcriptional factor downstream of the type 1 IFN signaling pathway. IFN-inducible genes were downregulated via IRF9 silencing using siRNA compared with the negative control treated with siRNA. Consistently, BA treatment reduced the proportion of senescent cells and IFN-inducible genes in etoposide-treated fibroblasts. Hence, BA alleviates cellular senescence via the inhibition of the type 1 IFN signaling pathway in dermal fibroblasts." @default.
• W4367296444 created "2023-04-29" @default.
• W4367296444 creator A5005811329 @default.
• W4367296444 creator A5031600041 @default.
• W4367296444 creator A5033250192 @default.
• W4367296444 creator A5035935266 @default.
• W4367296444 creator A5047211504 @default.
• W4367296444 creator A5050436628 @default.
• W4367296444 creator A5069711734 @default.
• W4367296444 date "2023-04-28" @default.
• W4367296444 modified "2023-10-09" @default.
• W4367296444 title "Effects of Betulinic Acid on the Proliferation, Cellular Senescence, and Type 1 Interferon-Related Signaling Pathways in Human Dermal Fibroblasts" @default.
• W4367296444 cites W1979009661 @default.
• W4367296444 cites W2010345740 @default.
• W4367296444 cites W2027298131 @default.
• W4367296444 cites W2048376317 @default.
• W4367296444 cites W2048829161 @default.
• W4367296444 cites W2069519394 @default.
• W4367296444 cites W2079104083 @default.
• W4367296444 cites W2126525177 @default.
• W4367296444 cites W2128378945 @default.
• W4367296444 cites W2128807350 @default.
• W4367296444 cites W2131974830 @default.
• W4367296444 cites W2404290522 @default.
• W4367296444 cites W2563381525 @default.
• W4367296444 cites W2734670913 @default.
• W4367296444 cites W2742007963 @default.
• W4367296444 cites W2756119006 @default.
• W4367296444 cites W2762611634 @default.
• W4367296444 cites W2775039013 @default.
• W4367296444 cites W2792709985 @default.
• W4367296444 cites W2795140302 @default.
• W4367296444 cites W2796888593 @default.
• W4367296444 cites W2800438504 @default.
• W4367296444 cites W2805184558 @default.
• W4367296444 cites W2810861436 @default.
• W4367296444 cites W2860743873 @default.
• W4367296444 cites W2893617001 @default.
• W4367296444 cites W2900136751 @default.
• W4367296444 cites W2944453374 @default.
• W4367296444 cites W2953870751 @default.
• W4367296444 cites W3062567037 @default.
• W4367296444 cites W3086498613 @default.
• W4367296444 cites W3155493998 @default.
• W4367296444 cites W3162806658 @default.
• W4367296444 cites W4200273754 @default.
• W4367296444 cites W4214817725 @default.
• W4367296444 cites W4224229902 @default.
• W4367296444 cites W4295907472 @default.
• W4367296444 doi "https://doi.org/10.1021/acs.jafc.2c08563" @default.
• W4367296444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37116884" @default.
• W4367296444 hasPublicationYear "2023" @default.
• W4367296444 type Work @default.
• W4367296444 citedByCount "1" @default.
• W4367296444 countsByYear W43672964442023 @default.
• W4367296444 crossrefType "journal-article" @default.
• W4367296444 hasAuthorship W4367296444A5005811329 @default.
• W4367296444 hasAuthorship W4367296444A5031600041 @default.
• W4367296444 hasAuthorship W4367296444A5033250192 @default.
• W4367296444 hasAuthorship W4367296444A5035935266 @default.
• W4367296444 hasAuthorship W4367296444A5047211504 @default.
• W4367296444 hasAuthorship W4367296444A5050436628 @default.
• W4367296444 hasAuthorship W4367296444A5069711734 @default.
• W4367296444 hasConcept C104317684 @default.
• W4367296444 hasConcept C119056186 @default.
• W4367296444 hasConcept C127561419 @default.
• W4367296444 hasConcept C150194340 @default.
• W4367296444 hasConcept C153911025 @default.
• W4367296444 hasConcept C185592680 @default.
• W4367296444 hasConcept C203014093 @default.
• W4367296444 hasConcept C2776178377 @default.
• W4367296444 hasConcept C2777829905 @default.
• W4367296444 hasConcept C522857546 @default.
• W4367296444 hasConcept C54355233 @default.
• W4367296444 hasConcept C55493867 @default.
• W4367296444 hasConcept C62112901 @default.
• W4367296444 hasConcept C62478195 @default.
• W4367296444 hasConcept C8415881 @default.
• W4367296444 hasConcept C86803240 @default.
• W4367296444 hasConcept C95444343 @default.
• W4367296444 hasConceptScore W4367296444C104317684 @default.
• W4367296444 hasConceptScore W4367296444C119056186 @default.
• W4367296444 hasConceptScore W4367296444C127561419 @default.
• W4367296444 hasConceptScore W4367296444C150194340 @default.
• W4367296444 hasConceptScore W4367296444C153911025 @default.
• W4367296444 hasConceptScore W4367296444C185592680 @default.
• W4367296444 hasConceptScore W4367296444C203014093 @default.
• W4367296444 hasConceptScore W4367296444C2776178377 @default.
• W4367296444 hasConceptScore W4367296444C2777829905 @default.
• W4367296444 hasConceptScore W4367296444C522857546 @default.
• W4367296444 hasConceptScore W4367296444C54355233 @default.
• W4367296444 hasConceptScore W4367296444C55493867 @default.
• W4367296444 hasConceptScore W4367296444C62112901 @default.
• W4367296444 hasConceptScore W4367296444C62478195 @default.
• W4367296444 hasConceptScore W4367296444C8415881 @default.
• W4367296444 hasConceptScore W4367296444C86803240 @default.
• W4367296444 hasConceptScore W4367296444C95444343 @default.
• W4367296444 hasFunder F4320327353 @default.

• next