Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367296843> ?p ?o ?g. }
- W4367296843 endingPage "1498" @default.
- W4367296843 startingPage "1485" @default.
- W4367296843 abstract "The role of the tumor microenvironment (TME) and intratumoral T cells in splenic marginal zone lymphoma (sMZL) is largely unknown. In the present study, we evaluated 36 sMZL spleen specimens by single cell analysis to gain a better understanding of the TME in sMZL. Using mass cytometry (CyTOF), we observed that the TME in sMZL is distinct from that of control non-malignant reactive spleen (rSP). We found that the number of TFH cells varied greatly in sMZL, ICOS+ TFH cells were more abundant in sMZL than rSP, and TFH cells positively correlated with increased numbers of memory B cells. Treg cell analysis revealed that TIGIT+ Treg cells are enriched in sMZL and correlate with suppression of TH17 and TH22 cells. Intratumoral CD8+ T cells were comprised of subsets of short-lived, exhausted and late-stage differentiated cells, thereby functionally impaired. We observed that T-cell exhaustion was present in sMZL and TIM-3 expression on PD-1low cells identified cells with severe immune dysfunction. Gene expression profiling by CITE-seq analysis validated this finding. Taken together, our data suggest that the TME as a whole, and T-cell population specifically, are heterogenous in sMZL and immune exhaustion is one of the major factors impairing T-cell function." @default.
- W4367296843 created "2023-04-29" @default.
- W4367296843 creator A5010322304 @default.
- W4367296843 creator A5017156539 @default.
- W4367296843 creator A5031537463 @default.
- W4367296843 creator A5033016169 @default.
- W4367296843 creator A5040160436 @default.
- W4367296843 creator A5044935392 @default.
- W4367296843 creator A5046495281 @default.
- W4367296843 creator A5049816813 @default.
- W4367296843 creator A5059729547 @default.
- W4367296843 creator A5063296982 @default.
- W4367296843 creator A5067247835 @default.
- W4367296843 creator A5068796848 @default.
- W4367296843 creator A5084324197 @default.
- W4367296843 date "2023-04-28" @default.
- W4367296843 modified "2023-10-12" @default.
- W4367296843 title "Characterization of immune exhaustion and suppression in the tumor microenvironment of splenic marginal zone lymphoma" @default.
- W4367296843 cites W1540592014 @default.
- W4367296843 cites W1546847318 @default.
- W4367296843 cites W1678412754 @default.
- W4367296843 cites W1968909135 @default.
- W4367296843 cites W1971425687 @default.
- W4367296843 cites W1976105607 @default.
- W4367296843 cites W1978020435 @default.
- W4367296843 cites W1978436252 @default.
- W4367296843 cites W1979773132 @default.
- W4367296843 cites W1987165863 @default.
- W4367296843 cites W1994257755 @default.
- W4367296843 cites W2014789164 @default.
- W4367296843 cites W2029399624 @default.
- W4367296843 cites W2041143310 @default.
- W4367296843 cites W2064610182 @default.
- W4367296843 cites W2085309730 @default.
- W4367296843 cites W2125616358 @default.
- W4367296843 cites W2139605769 @default.
- W4367296843 cites W2150492554 @default.
- W4367296843 cites W2155764740 @default.
- W4367296843 cites W2158333823 @default.
- W4367296843 cites W2167556523 @default.
- W4367296843 cites W2343596911 @default.
- W4367296843 cites W2410845838 @default.
- W4367296843 cites W2412725897 @default.
- W4367296843 cites W2463733433 @default.
- W4367296843 cites W2553178734 @default.
- W4367296843 cites W2605683323 @default.
- W4367296843 cites W2618433578 @default.
- W4367296843 cites W2618667882 @default.
- W4367296843 cites W2766915823 @default.
- W4367296843 cites W2804786344 @default.
- W4367296843 cites W2810262638 @default.
- W4367296843 cites W2890876244 @default.
- W4367296843 cites W2909334052 @default.
- W4367296843 cites W2911876402 @default.
- W4367296843 cites W2917986195 @default.
- W4367296843 cites W2964858496 @default.
- W4367296843 cites W2968942240 @default.
- W4367296843 cites W3010440315 @default.
- W4367296843 cites W3012215575 @default.
- W4367296843 cites W3205992773 @default.
- W4367296843 cites W4240098044 @default.
- W4367296843 cites W4282917406 @default.
- W4367296843 cites W4286632131 @default.
- W4367296843 doi "https://doi.org/10.1038/s41375-023-01911-2" @default.
- W4367296843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37117318" @default.
- W4367296843 hasPublicationYear "2023" @default.
- W4367296843 type Work @default.
- W4367296843 citedByCount "0" @default.
- W4367296843 crossrefType "journal-article" @default.
- W4367296843 hasAuthorship W4367296843A5010322304 @default.
- W4367296843 hasAuthorship W4367296843A5017156539 @default.
- W4367296843 hasAuthorship W4367296843A5031537463 @default.
- W4367296843 hasAuthorship W4367296843A5033016169 @default.
- W4367296843 hasAuthorship W4367296843A5040160436 @default.
- W4367296843 hasAuthorship W4367296843A5044935392 @default.
- W4367296843 hasAuthorship W4367296843A5046495281 @default.
- W4367296843 hasAuthorship W4367296843A5049816813 @default.
- W4367296843 hasAuthorship W4367296843A5059729547 @default.
- W4367296843 hasAuthorship W4367296843A5063296982 @default.
- W4367296843 hasAuthorship W4367296843A5067247835 @default.
- W4367296843 hasAuthorship W4367296843A5068796848 @default.
- W4367296843 hasAuthorship W4367296843A5084324197 @default.
- W4367296843 hasBestOaLocation W43672968432 @default.
- W4367296843 hasConcept C104317684 @default.
- W4367296843 hasConcept C127716648 @default.
- W4367296843 hasConcept C159654299 @default.
- W4367296843 hasConcept C167672396 @default.
- W4367296843 hasConcept C203014093 @default.
- W4367296843 hasConcept C2776090121 @default.
- W4367296843 hasConcept C2776107976 @default.
- W4367296843 hasConcept C2776309230 @default.
- W4367296843 hasConcept C2778015335 @default.
- W4367296843 hasConcept C2778453870 @default.
- W4367296843 hasConcept C2779118045 @default.
- W4367296843 hasConcept C2779338263 @default.
- W4367296843 hasConcept C2779380147 @default.
- W4367296843 hasConcept C2779921676 @default.
- W4367296843 hasConcept C2780931953 @default.