FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367296844> ?p ?o ?g. }

• W4367296844 abstract "Abstract Hemolysis is the process of rupturing erythrocytes (red blood cells) by forming nanopores on their membranes using hemolysins, which then impede membrane permeability. However, the self‐assembly process before the state of transmembrane pores and underlying mechanisms of conformational change are not fully understood. In this work, theoretical and experimental evidence of the pre‐pore morphology of Clostridium perfringens epsilon toxin (ETX), a typical hemolysin, is provided using in situ atomic force microscopy (AFM) complemented by molecular dynamics (MD) simulations to detect the conformational distribution of different states in Mica. The AFM suggests that the ETX pore is formed in two stages: ETX monomers first attach to the membrane and form a pre‐pore in no special conditions required, which then undergo a conformational change to form a transmembrane pore at temperatures above the critical point in the presence of receptors. The authors’ MD simulations reveal that initial nucleation occurs when specific amino acids adsorb to negatively charged mica cavities. This work fills the knowledge gap in understanding the early stage of hemolysis and the oligomerization of hemolysins. Moreover, the newly identified pre‐pore of ETX holds promise as a candidate for nanopore applications." @default.
• W4367296844 created "2023-04-29" @default.
• W4367296844 creator A5021280842 @default.
• W4367296844 creator A5024178881 @default.
• W4367296844 creator A5024464343 @default.
• W4367296844 creator A5025408369 @default.
• W4367296844 creator A5054064979 @default.
• W4367296844 creator A5060822545 @default.
• W4367296844 creator A5064430504 @default.
• W4367296844 creator A5066102428 @default.
• W4367296844 creator A5068791026 @default.
• W4367296844 creator A5078014032 @default.
• W4367296844 creator A5079815413 @default.
• W4367296844 date "2023-04-28" @default.
• W4367296844 modified "2023-10-14" @default.
• W4367296844 title "Direct Visualization of the Dynamic Process of Epsilon Toxin on Hemolysis" @default.
• W4367296844 cites W1031578623 @default.
• W4367296844 cites W1847021296 @default.
• W4367296844 cites W1976499671 @default.
• W4367296844 cites W1978089204 @default.
• W4367296844 cites W1982129633 @default.
• W4367296844 cites W1999285513 @default.
• W4367296844 cites W2018054206 @default.
• W4367296844 cites W2021520922 @default.
• W4367296844 cites W2027492022 @default.
• W4367296844 cites W2029667189 @default.
• W4367296844 cites W2029833454 @default.
• W4367296844 cites W2035266068 @default.
• W4367296844 cites W2036070425 @default.
• W4367296844 cites W2039617999 @default.
• W4367296844 cites W2057477511 @default.
• W4367296844 cites W2067174909 @default.
• W4367296844 cites W2068119233 @default.
• W4367296844 cites W2068937960 @default.
• W4367296844 cites W2070783600 @default.
• W4367296844 cites W2081032354 @default.
• W4367296844 cites W2086047770 @default.
• W4367296844 cites W2089934202 @default.
• W4367296844 cites W2109154308 @default.
• W4367296844 cites W2118878149 @default.
• W4367296844 cites W2128572087 @default.
• W4367296844 cites W2138150368 @default.
• W4367296844 cites W2146377497 @default.
• W4367296844 cites W2154895333 @default.
• W4367296844 cites W2165810579 @default.
• W4367296844 cites W2171510183 @default.
• W4367296844 cites W2195219082 @default.
• W4367296844 cites W2197240885 @default.
• W4367296844 cites W2285181678 @default.
• W4367296844 cites W2297203981 @default.
• W4367296844 cites W2328852367 @default.
• W4367296844 cites W2387791141 @default.
• W4367296844 cites W2471671221 @default.
• W4367296844 cites W2574635384 @default.
• W4367296844 cites W2584282544 @default.
• W4367296844 cites W2595137052 @default.
• W4367296844 cites W2604286980 @default.
• W4367296844 cites W2625957644 @default.
• W4367296844 cites W2895654676 @default.
• W4367296844 cites W2921698928 @default.
• W4367296844 cites W2937890620 @default.
• W4367296844 cites W2943245415 @default.
• W4367296844 cites W2951391808 @default.
• W4367296844 cites W2952148325 @default.
• W4367296844 cites W2971777341 @default.
• W4367296844 cites W2989578970 @default.
• W4367296844 cites W3029202815 @default.
• W4367296844 cites W4288096375 @default.
• W4367296844 cites W4293115980 @default.
• W4367296844 cites W986392369 @default.
• W4367296844 doi "https://doi.org/10.1002/smtd.202300028" @default.
• W4367296844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37116083" @default.
• W4367296844 hasPublicationYear "2023" @default.
• W4367296844 type Work @default.
• W4367296844 citedByCount "0" @default.
• W4367296844 crossrefType "journal-article" @default.
• W4367296844 hasAuthorship W4367296844A5021280842 @default.
• W4367296844 hasAuthorship W4367296844A5024178881 @default.
• W4367296844 hasAuthorship W4367296844A5024464343 @default.
• W4367296844 hasAuthorship W4367296844A5025408369 @default.
• W4367296844 hasAuthorship W4367296844A5054064979 @default.
• W4367296844 hasAuthorship W4367296844A5060822545 @default.
• W4367296844 hasAuthorship W4367296844A5064430504 @default.
• W4367296844 hasAuthorship W4367296844A5066102428 @default.
• W4367296844 hasAuthorship W4367296844A5068791026 @default.
• W4367296844 hasAuthorship W4367296844A5078014032 @default.
• W4367296844 hasAuthorship W4367296844A5079815413 @default.
• W4367296844 hasBestOaLocation W43672968441 @default.
• W4367296844 hasConcept C104317684 @default.
• W4367296844 hasConcept C12554922 @default.
• W4367296844 hasConcept C136139683 @default.
• W4367296844 hasConcept C141795571 @default.
• W4367296844 hasConcept C147597530 @default.
• W4367296844 hasConcept C159467904 @default.
• W4367296844 hasConcept C170493617 @default.
• W4367296844 hasConcept C171250308 @default.
• W4367296844 hasConcept C174921431 @default.
• W4367296844 hasConcept C178790620 @default.
• W4367296844 hasConcept C185592680 @default.
• W4367296844 hasConcept C192562407 @default.

• next