Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367297411> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4367297411 endingPage "100150" @default.
- W4367297411 startingPage "100150" @default.
- W4367297411 abstract "Background & Aims The use of direct acting antiviral agents (DAAs) in patients with chronic HCV genotype (GT) 3a infection results in sustained virologic response (SVR) rates of 93–98%, but 5–8% of patients experience virologic failure. Methods. We observed 48 patients infected with HCV subtype 3a who failed previous treatment with DAAs, including 43 subjects (89.6%) with liver cirrhosis. Thirty-seven (77%) subjects previously received NS5A inhibitors of the first generation (daclatasvir) and 11 subjects (23%) – of the second generation (velpatasvir). All patients received retreatment with sofosbuvir (SOF)/ velpatasvir (VEL) and ribavirin (RBV) for 24 weeks. We compared SVR12 rates depending on fibrosis stage, presence of NS5A mutation (L31M or A30K and Y93H), and on the generation of previously used NS5A inhibitors. Results. Observed SVR12 rate were: 83,3% (40/48 patients) overall; 100% in patients without cirrhosis (n=5) vs 81,4% (n=35) in those with cirrhosis (n=43) (P=0,01); 86,7% (n=13) with single L31M or A30K(n=15) vs 77,8% (n=21) with Y93H mutation (n=27) (P=0,46), 86,5% (n=32) in patients who previously failed first generation (n=37) vs 72,7% (n=8) in those who failed second generation NS5A inhibitors (n=11) (P=0,35). Conclusions. Retreatment with SOF/VEL+RBV was highly effective and safe in patients with chronic HCV GT3a infection, including those with liver cirrhosis, who previously failed DAA containing NS5A inhibitors. Presence of NS5A RASs L31M, A30K, and Y93H at the baseline, as well as the generation of previously used NS5A inhibitors did not impact SVR12 rates." @default.
- W4367297411 created "2023-04-29" @default.
- W4367297411 creator A5042467299 @default.
- W4367297411 creator A5050677659 @default.
- W4367297411 creator A5073904197 @default.
- W4367297411 creator A5080482627 @default.
- W4367297411 date "2023-06-01" @default.
- W4367297411 modified "2023-10-14" @default.
- W4367297411 title "Retreatment of patients with chronic hepatitis C, subtype 3a, and cirrhosis, who previously failed a regimen containing NS5A inhibitors with sofosbuvir/velpatasvir plus ribavirin for 24 weeks" @default.
- W4367297411 cites W2035804055 @default.
- W4367297411 cites W2037251110 @default.
- W4367297411 cites W2049370512 @default.
- W4367297411 cites W2121209352 @default.
- W4367297411 cites W2289667014 @default.
- W4367297411 cites W2553439691 @default.
- W4367297411 cites W2578013986 @default.
- W4367297411 cites W2739670275 @default.
- W4367297411 cites W2750060262 @default.
- W4367297411 cites W2789810042 @default.
- W4367297411 cites W2794248499 @default.
- W4367297411 cites W2810986710 @default.
- W4367297411 cites W2913425615 @default.
- W4367297411 cites W2969974394 @default.
- W4367297411 cites W2970340545 @default.
- W4367297411 cites W2987870062 @default.
- W4367297411 cites W2998988013 @default.
- W4367297411 cites W3013683696 @default.
- W4367297411 cites W3027214204 @default.
- W4367297411 cites W3088020815 @default.
- W4367297411 cites W3098168521 @default.
- W4367297411 cites W3118880158 @default.
- W4367297411 cites W3123923425 @default.
- W4367297411 cites W3126466671 @default.
- W4367297411 cites W3134737308 @default.
- W4367297411 cites W3186670979 @default.
- W4367297411 cites W3206517792 @default.
- W4367297411 cites W4280511719 @default.
- W4367297411 cites W4283169147 @default.
- W4367297411 doi "https://doi.org/10.1016/j.jcvp.2023.100150" @default.
- W4367297411 hasPublicationYear "2023" @default.
- W4367297411 type Work @default.
- W4367297411 citedByCount "0" @default.
- W4367297411 crossrefType "journal-article" @default.
- W4367297411 hasAuthorship W4367297411A5042467299 @default.
- W4367297411 hasAuthorship W4367297411A5050677659 @default.
- W4367297411 hasAuthorship W4367297411A5073904197 @default.
- W4367297411 hasAuthorship W4367297411A5080482627 @default.
- W4367297411 hasBestOaLocation W43672974111 @default.
- W4367297411 hasConcept C126322002 @default.
- W4367297411 hasConcept C159047783 @default.
- W4367297411 hasConcept C2522874641 @default.
- W4367297411 hasConcept C2776408679 @default.
- W4367297411 hasConcept C2776455275 @default.
- W4367297411 hasConcept C2776979040 @default.
- W4367297411 hasConcept C2777103181 @default.
- W4367297411 hasConcept C2777214474 @default.
- W4367297411 hasConcept C2778390639 @default.
- W4367297411 hasConcept C2780040827 @default.
- W4367297411 hasConcept C2781413609 @default.
- W4367297411 hasConcept C2781463415 @default.
- W4367297411 hasConcept C3020491458 @default.
- W4367297411 hasConcept C71924100 @default.
- W4367297411 hasConcept C90924648 @default.
- W4367297411 hasConceptScore W4367297411C126322002 @default.
- W4367297411 hasConceptScore W4367297411C159047783 @default.
- W4367297411 hasConceptScore W4367297411C2522874641 @default.
- W4367297411 hasConceptScore W4367297411C2776408679 @default.
- W4367297411 hasConceptScore W4367297411C2776455275 @default.
- W4367297411 hasConceptScore W4367297411C2776979040 @default.
- W4367297411 hasConceptScore W4367297411C2777103181 @default.
- W4367297411 hasConceptScore W4367297411C2777214474 @default.
- W4367297411 hasConceptScore W4367297411C2778390639 @default.
- W4367297411 hasConceptScore W4367297411C2780040827 @default.
- W4367297411 hasConceptScore W4367297411C2781413609 @default.
- W4367297411 hasConceptScore W4367297411C2781463415 @default.
- W4367297411 hasConceptScore W4367297411C3020491458 @default.
- W4367297411 hasConceptScore W4367297411C71924100 @default.
- W4367297411 hasConceptScore W4367297411C90924648 @default.
- W4367297411 hasIssue "2" @default.
- W4367297411 hasLocation W43672974111 @default.
- W4367297411 hasOpenAccess W4367297411 @default.
- W4367297411 hasPrimaryLocation W43672974111 @default.
- W4367297411 hasRelatedWork W2024150911 @default.
- W4367297411 hasRelatedWork W2114705120 @default.
- W4367297411 hasRelatedWork W2172454869 @default.
- W4367297411 hasRelatedWork W2560876434 @default.
- W4367297411 hasRelatedWork W2585250246 @default.
- W4367297411 hasRelatedWork W2767376718 @default.
- W4367297411 hasRelatedWork W3031498534 @default.
- W4367297411 hasRelatedWork W3110716148 @default.
- W4367297411 hasRelatedWork W4289815992 @default.
- W4367297411 hasRelatedWork W4360862229 @default.
- W4367297411 hasVolume "3" @default.
- W4367297411 isParatext "false" @default.
- W4367297411 isRetracted "false" @default.
- W4367297411 workType "article" @default.