Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367298975> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4367298975 endingPage "105527" @default.
- W4367298975 startingPage "105527" @default.
- W4367298975 abstract "Shikonin is the main active ingredient in Arnebiae Radix, an herbal medicine with anti-inflammatory and hemostatic effects, yet which mechanism remains unveiled. Urokinase-type plasminogen activator (uPA) not only regulates fibrinolysis, but also modulates macrophage invasion, matrix remodeling and adhesion. This study examined whether uPA participated in the anti-inflammatory activity of Shikonin on LPS-induced mice acute lung-injury (ALI) and RAW264.7 models, and investigated whether Shikonin mediated a hemostatic effect by inhibiting uPA in animal serum. The results showed that Shikonin ameliorated inflammation and reduced uPA in the lung of ALI mice. Proteomic results revealed that Shikonin markedly decreased uPA, MMP-9 and pro-inflammatory cytokines in macrophages. Besides, Shikonin decreased serum uPA and promoted blood coagulation. Collectively, current data suggested that Shikonin inhibited uPA, which possibly associated with its anti-inflammatory and hemostatic effects." @default.
- W4367298975 created "2023-04-29" @default.
- W4367298975 creator A5004343457 @default.
- W4367298975 creator A5021253561 @default.
- W4367298975 creator A5024409772 @default.
- W4367298975 creator A5028179790 @default.
- W4367298975 creator A5034308015 @default.
- W4367298975 creator A5061723044 @default.
- W4367298975 creator A5064138532 @default.
- W4367298975 date "2023-06-01" @default.
- W4367298975 modified "2023-10-16" @default.
- W4367298975 title "Shikonin mediated anti-acute lung injury and hemostatic effects via inhibiting uPA" @default.
- W4367298975 cites W1924528760 @default.
- W4367298975 cites W1967713787 @default.
- W4367298975 cites W1974471520 @default.
- W4367298975 cites W1991217765 @default.
- W4367298975 cites W1998935905 @default.
- W4367298975 cites W2131416447 @default.
- W4367298975 cites W2155819806 @default.
- W4367298975 cites W2166226531 @default.
- W4367298975 cites W2317488575 @default.
- W4367298975 cites W2318410418 @default.
- W4367298975 cites W2370339191 @default.
- W4367298975 cites W2775252403 @default.
- W4367298975 cites W2802971089 @default.
- W4367298975 cites W2892372248 @default.
- W4367298975 cites W2919279492 @default.
- W4367298975 cites W2945934997 @default.
- W4367298975 cites W2969802310 @default.
- W4367298975 cites W3110790698 @default.
- W4367298975 cites W3154855081 @default.
- W4367298975 cites W3177462871 @default.
- W4367298975 cites W3195108485 @default.
- W4367298975 cites W4205163336 @default.
- W4367298975 cites W4221055057 @default.
- W4367298975 cites W4225123881 @default.
- W4367298975 cites W4293105580 @default.
- W4367298975 cites W4308737640 @default.
- W4367298975 cites W4311118070 @default.
- W4367298975 cites W4313224256 @default.
- W4367298975 doi "https://doi.org/10.1016/j.jff.2023.105527" @default.
- W4367298975 hasPublicationYear "2023" @default.
- W4367298975 type Work @default.
- W4367298975 citedByCount "0" @default.
- W4367298975 crossrefType "journal-article" @default.
- W4367298975 hasAuthorship W4367298975A5004343457 @default.
- W4367298975 hasAuthorship W4367298975A5021253561 @default.
- W4367298975 hasAuthorship W4367298975A5024409772 @default.
- W4367298975 hasAuthorship W4367298975A5028179790 @default.
- W4367298975 hasAuthorship W4367298975A5034308015 @default.
- W4367298975 hasAuthorship W4367298975A5061723044 @default.
- W4367298975 hasAuthorship W4367298975A5064138532 @default.
- W4367298975 hasBestOaLocation W43672989751 @default.
- W4367298975 hasConcept C126322002 @default.
- W4367298975 hasConcept C164027704 @default.
- W4367298975 hasConcept C185592680 @default.
- W4367298975 hasConcept C203014093 @default.
- W4367298975 hasConcept C2776825266 @default.
- W4367298975 hasConcept C2776892390 @default.
- W4367298975 hasConcept C2776914184 @default.
- W4367298975 hasConcept C2779679481 @default.
- W4367298975 hasConcept C71924100 @default.
- W4367298975 hasConcept C98274493 @default.
- W4367298975 hasConceptScore W4367298975C126322002 @default.
- W4367298975 hasConceptScore W4367298975C164027704 @default.
- W4367298975 hasConceptScore W4367298975C185592680 @default.
- W4367298975 hasConceptScore W4367298975C203014093 @default.
- W4367298975 hasConceptScore W4367298975C2776825266 @default.
- W4367298975 hasConceptScore W4367298975C2776892390 @default.
- W4367298975 hasConceptScore W4367298975C2776914184 @default.
- W4367298975 hasConceptScore W4367298975C2779679481 @default.
- W4367298975 hasConceptScore W4367298975C71924100 @default.
- W4367298975 hasConceptScore W4367298975C98274493 @default.
- W4367298975 hasFunder F4320321001 @default.
- W4367298975 hasFunder F4320321921 @default.
- W4367298975 hasLocation W43672989751 @default.
- W4367298975 hasOpenAccess W4367298975 @default.
- W4367298975 hasPrimaryLocation W43672989751 @default.
- W4367298975 hasRelatedWork W1986325054 @default.
- W4367298975 hasRelatedWork W1987351278 @default.
- W4367298975 hasRelatedWork W2165578318 @default.
- W4367298975 hasRelatedWork W2313033156 @default.
- W4367298975 hasRelatedWork W2406606844 @default.
- W4367298975 hasRelatedWork W2417756525 @default.
- W4367298975 hasRelatedWork W2427132053 @default.
- W4367298975 hasRelatedWork W2433598040 @default.
- W4367298975 hasRelatedWork W2466223857 @default.
- W4367298975 hasRelatedWork W322829953 @default.
- W4367298975 hasVolume "105" @default.
- W4367298975 isParatext "false" @default.
- W4367298975 isRetracted "false" @default.
- W4367298975 workType "article" @default.