FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367299726> ?p ?o ?g. }

• W4367299726 endingPage "106933" @default.
• W4367299726 startingPage "106933" @default.
• W4367299726 abstract "Lung cancer is the malignant tumor with the highest mortality rate in the world. There is obvious heterogeneity within the tumor. Single cell sequencing technology enables scholars to obtain information about the cell type, status, subpopulation distribution and communication behavior between cells in the tumor microenvironment from the cellular level. However, due to the problem of sequencing depth, some genes with low expression cannot be detected, which results in that most of the specific genes of immune cells cannot be recognized, and lead to defects in the functional identification of immune cells. In this paper, we used single cell sequencing data of 12346 T cells in 14 treatment-naïve non-small-cell lung cancer patients to identify immune cell-specific genes and infer the function of three types of T cells. The method, named GRAPH-LC, implemented this function by gene interaction network and graph learning methods. Graph learning methods are used to extract genes feature and dense neural network is used to identify immune cell-specific genes. The experiments on 10-cross validation shows that the AUROC and AUPR reached at least 0.802, 0.815 on identifying cell-specific genes of three types of T cells. And we did functional enrichment analysis on the top 15 expressed genes. By functional enrichment analysis, we got 95 GO terms and 39 KEGG pathways that related to three types of T cells. The use of this technology will help to deeply understand the mechanism of the occurrence and development of lung cancer, find new diagnostic markers and therapeutic targets, and provide a theoretical reference for the precise treatment of lung cancer patients in the future." @default.
• W4367299726 created "2023-04-29" @default.
• W4367299726 creator A5003799076 @default.
• W4367299726 creator A5083755109 @default.
• W4367299726 date "2023-06-01" @default.
• W4367299726 modified "2023-10-16" @default.
• W4367299726 title "Function of CD8+, conventional CD4+, and regulatory CD4+ T cell identification in lung cancer" @default.
• W4367299726 cites W1891956616 @default.
• W4367299726 cites W2032518018 @default.
• W4367299726 cites W2079819818 @default.
• W4367299726 cites W2104268053 @default.
• W4367299726 cites W2149573463 @default.
• W4367299726 cites W2808837841 @default.
• W4367299726 cites W2865352686 @default.
• W4367299726 cites W2909936201 @default.
• W4367299726 cites W2936414047 @default.
• W4367299726 cites W2980411087 @default.
• W4367299726 cites W2980495984 @default.
• W4367299726 cites W2995410603 @default.
• W4367299726 cites W2997008807 @default.
• W4367299726 cites W3022968840 @default.
• W4367299726 cites W3031915029 @default.
• W4367299726 cites W3043335732 @default.
• W4367299726 cites W3078555423 @default.
• W4367299726 cites W3091035534 @default.
• W4367299726 cites W3091850962 @default.
• W4367299726 cites W3095479837 @default.
• W4367299726 cites W3114090031 @default.
• W4367299726 cites W3126698360 @default.
• W4367299726 cites W3138985726 @default.
• W4367299726 cites W3156862851 @default.
• W4367299726 cites W3170943164 @default.
• W4367299726 cites W3181005890 @default.
• W4367299726 cites W3194137039 @default.
• W4367299726 cites W3197858765 @default.
• W4367299726 cites W3199355169 @default.
• W4367299726 cites W3215142552 @default.
• W4367299726 cites W4210257598 @default.
• W4367299726 cites W4221040962 @default.
• W4367299726 cites W4226021238 @default.
• W4367299726 cites W4226093494 @default.
• W4367299726 cites W4280597232 @default.
• W4367299726 cites W4308834336 @default.
• W4367299726 cites W4313148629 @default.
• W4367299726 doi "https://doi.org/10.1016/j.compbiomed.2023.106933" @default.
• W4367299726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37156220" @default.
• W4367299726 hasPublicationYear "2023" @default.
• W4367299726 type Work @default.
• W4367299726 citedByCount "1" @default.
• W4367299726 countsByYear W43672997262023 @default.
• W4367299726 crossrefType "journal-article" @default.
• W4367299726 hasAuthorship W4367299726A5003799076 @default.
• W4367299726 hasAuthorship W4367299726A5083755109 @default.
• W4367299726 hasConcept C104317684 @default.
• W4367299726 hasConcept C142724271 @default.
• W4367299726 hasConcept C1491633281 @default.
• W4367299726 hasConcept C150194340 @default.
• W4367299726 hasConcept C152724338 @default.
• W4367299726 hasConcept C162317418 @default.
• W4367299726 hasConcept C167672396 @default.
• W4367299726 hasConcept C189014844 @default.
• W4367299726 hasConcept C203014093 @default.
• W4367299726 hasConcept C2776090121 @default.
• W4367299726 hasConcept C2776107976 @default.
• W4367299726 hasConcept C2776256026 @default.
• W4367299726 hasConcept C54355233 @default.
• W4367299726 hasConcept C70721500 @default.
• W4367299726 hasConcept C71924100 @default.
• W4367299726 hasConcept C86803240 @default.
• W4367299726 hasConcept C8891405 @default.
• W4367299726 hasConceptScore W4367299726C104317684 @default.
• W4367299726 hasConceptScore W4367299726C142724271 @default.
• W4367299726 hasConceptScore W4367299726C1491633281 @default.
• W4367299726 hasConceptScore W4367299726C150194340 @default.
• W4367299726 hasConceptScore W4367299726C152724338 @default.
• W4367299726 hasConceptScore W4367299726C162317418 @default.
• W4367299726 hasConceptScore W4367299726C167672396 @default.
• W4367299726 hasConceptScore W4367299726C189014844 @default.
• W4367299726 hasConceptScore W4367299726C203014093 @default.
• W4367299726 hasConceptScore W4367299726C2776090121 @default.
• W4367299726 hasConceptScore W4367299726C2776107976 @default.
• W4367299726 hasConceptScore W4367299726C2776256026 @default.
• W4367299726 hasConceptScore W4367299726C54355233 @default.
• W4367299726 hasConceptScore W4367299726C70721500 @default.
• W4367299726 hasConceptScore W4367299726C71924100 @default.
• W4367299726 hasConceptScore W4367299726C86803240 @default.
• W4367299726 hasConceptScore W4367299726C8891405 @default.
• W4367299726 hasLocation W43672997261 @default.
• W4367299726 hasLocation W43672997262 @default.
• W4367299726 hasOpenAccess W4367299726 @default.
• W4367299726 hasPrimaryLocation W43672997261 @default.
• W4367299726 hasRelatedWork W2009966535 @default.
• W4367299726 hasRelatedWork W2021523535 @default.
• W4367299726 hasRelatedWork W2582414407 @default.
• W4367299726 hasRelatedWork W2748644580 @default.
• W4367299726 hasRelatedWork W2754087939 @default.
• W4367299726 hasRelatedWork W2909382709 @default.
• W4367299726 hasRelatedWork W3197243161 @default.

• next