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- W4367299764 abstract "Despite the large arsenal of analgesic medications, neuropathic pain (NP) management is not solved yet. Angiotensin II receptor type 1 (AT1) has been identified as a potential target in NP therapy. Here, we investigate the antiallodynic effect of AT1 blockers telmisartan and losartan, and particularly their combination with morphine on rat mononeuropathic pain following acute or chronic oral administration. The impact of telmisartan on morphine analgesic tolerance was also assessed using the rat tail-flick assay. Morphine potency and efficacy in spinal cord samples of treated neuropathic animals were assessed by [35S]GTPγS-binding assay. Finally, the glutamate content of the cerebrospinal fluid (CSF) was measured by capillary electrophoresis. Oral telmisartan or losartan in higher doses showed an acute antiallodynic effect. In the chronic treatment study, the combination of subanalgesic doses of telmisartan and morphine ameliorated allodynia and resulted in a leftward shift in the dose–response curve of morphine in the [35S]GTPγS binding assay and increased CSF glutamate content. Telmisartan delayed morphine analgesic-tolerance development. Our study has identified a promising combination therapy composed of telmisartan and morphine for NP and opioid tolerance. Since telmisartan is an inhibitor of AT1 and activator of PPAR-γ, future studies are needed to analyze the effect of each component." @default.
- W4367299764 created "2023-04-29" @default.
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- W4367299764 date "2023-04-27" @default.
- W4367299764 modified "2023-10-09" @default.
- W4367299764 title "Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats" @default.
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- W4367299764 cites W1969904009 @default.
- W4367299764 cites W1972647407 @default.
- W4367299764 cites W1974017013 @default.
- W4367299764 cites W1978144435 @default.
- W4367299764 cites W1979297235 @default.
- W4367299764 cites W1979700346 @default.
- W4367299764 cites W1983318444 @default.
- W4367299764 cites W1985719155 @default.
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- W4367299764 cites W2003372025 @default.
- W4367299764 cites W2010651929 @default.
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- W4367299764 cites W2800256118 @default.
- W4367299764 cites W2888589263 @default.
- W4367299764 cites W2896951195 @default.
- W4367299764 cites W2911351633 @default.
- W4367299764 cites W2936347490 @default.
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- W4367299764 cites W3028694118 @default.
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- W4367299764 doi "https://doi.org/10.3390/ijms24097970" @default.
- W4367299764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37175678" @default.
- W4367299764 hasPublicationYear "2023" @default.
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