FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367299898> ?p ?o ?g. }

• W4367299898 abstract "Ovarian cancer (OC) is the most lethal gynecological cancer. In 2018, it was responsible for over 180,000 deaths worldwide. The high mortality rate is the culmination of a lack of early diagnosis and high rates of chemotherapy resistance, which is synonymous with disease recurrence. Over the last two decades, an increasingly significant role of epigenetic mechanisms, in particular DNA methylation, has emerged. This review will discuss several of the most significant genes whose hypo/hypermethylation profiles are associated with chemoresistance. Aside from functionally elucidating and evaluating these epimutations, this review will discuss recent trials of DNA methyltransferase inhibitors (DNMTi). Finally, we will propose future directions that could enhance the feasibility of utilizing these candidate epimutations as clinical biomarkers.To perform this review, a comprehensive literature search based on our keywords was conducted across the online databases PubMed and Google Scholar for identifying relevant studies published up until August 2022.Epimutations affecting MLH1, MSH2, and Ras-association domain family 1 isoform A (DNA damage repair and apoptosis); ATP-binding cassette subfamily B member 1 and methylation-controlled J (drug export); secreted frizzled-related proteins (Wnt/β-catenin signaling), neurocalcin delta (calcium and G protein-coupled receptor signaling), and zinc finger protein 671 all have potential as biomarkers for chemoresistance. However, specific uncertainties relating to these epimutations include histotype-specific differences, intrinsic versus acquired chemoresistance, and the interplay with complete surgical debulking. DNMTi for chemoresistant OC patients has shown some promise; however, issues surrounding their efficacy and dose-limiting toxicities remain; a personalized approach is required to maximize their effectiveness.Establishing a panel of aberrantly methylated chemoresistance-related genes to predict chemoresponsiveness and patients' suitability to DNMTi could significantly reduce OC recurrence, while improving DNMTi therapy viability. To achieve this, a large-scale prospective genome-wide DNA methylation profile study that spans different histotypes, includes paired samples (before and after chemotherapy), and integrates transcriptomic and methylomic analysis, is warranted." @default.
• W4367299898 created "2023-04-29" @default.
• W4367299898 creator A5008325011 @default.
• W4367299898 creator A5071595533 @default.
• W4367299898 date "2023-04-27" @default.
• W4367299898 modified "2023-09-24" @default.
• W4367299898 title "The role of DNA methylation in ovarian cancer chemoresistance: A narrative review" @default.
• W4367299898 cites W1492521210 @default.
• W4367299898 cites W1493801922 @default.
• W4367299898 cites W1501553071 @default.
• W4367299898 cites W1528319534 @default.
• W4367299898 cites W1546270188 @default.
• W4367299898 cites W1550210631 @default.
• W4367299898 cites W1552528612 @default.
• W4367299898 cites W1695398347 @default.
• W4367299898 cites W1895798608 @default.
• W4367299898 cites W1924694174 @default.
• W4367299898 cites W1969278255 @default.
• W4367299898 cites W1974747095 @default.
• W4367299898 cites W1974995008 @default.
• W4367299898 cites W1976731741 @default.
• W4367299898 cites W1979879868 @default.
• W4367299898 cites W1981440982 @default.
• W4367299898 cites W1988373085 @default.
• W4367299898 cites W1992882573 @default.
• W4367299898 cites W1993253909 @default.
• W4367299898 cites W1993463141 @default.
• W4367299898 cites W1997981312 @default.
• W4367299898 cites W2003673069 @default.
• W4367299898 cites W2005374850 @default.
• W4367299898 cites W2005428197 @default.
• W4367299898 cites W2013432817 @default.
• W4367299898 cites W2017563884 @default.
• W4367299898 cites W2019535129 @default.
• W4367299898 cites W2020458598 @default.
• W4367299898 cites W2022240113 @default.
• W4367299898 cites W2027102338 @default.
• W4367299898 cites W2027928327 @default.
• W4367299898 cites W2029918034 @default.
• W4367299898 cites W2032091934 @default.
• W4367299898 cites W2034687480 @default.
• W4367299898 cites W2036571761 @default.
• W4367299898 cites W2050202644 @default.
• W4367299898 cites W2051398284 @default.
• W4367299898 cites W2054407912 @default.
• W4367299898 cites W2060125529 @default.
• W4367299898 cites W2066840282 @default.
• W4367299898 cites W2070407979 @default.
• W4367299898 cites W2080288476 @default.
• W4367299898 cites W2082040301 @default.
• W4367299898 cites W2082399900 @default.
• W4367299898 cites W2085947779 @default.
• W4367299898 cites W2093407516 @default.
• W4367299898 cites W2095972733 @default.
• W4367299898 cites W2102179098 @default.
• W4367299898 cites W2106341289 @default.
• W4367299898 cites W2106391833 @default.
• W4367299898 cites W2109167689 @default.
• W4367299898 cites W2111836054 @default.
• W4367299898 cites W2115954319 @default.
• W4367299898 cites W2116538720 @default.
• W4367299898 cites W2120687087 @default.
• W4367299898 cites W2130215449 @default.
• W4367299898 cites W2130712410 @default.
• W4367299898 cites W2136905998 @default.
• W4367299898 cites W2143004704 @default.
• W4367299898 cites W2144263549 @default.
• W4367299898 cites W2151783390 @default.
• W4367299898 cites W2153104803 @default.
• W4367299898 cites W2159072674 @default.
• W4367299898 cites W2160234594 @default.
• W4367299898 cites W2162726435 @default.
• W4367299898 cites W2164778107 @default.
• W4367299898 cites W2165050206 @default.
• W4367299898 cites W2281254500 @default.
• W4367299898 cites W2317234826 @default.
• W4367299898 cites W2320228714 @default.
• W4367299898 cites W2343475249 @default.
• W4367299898 cites W2398785984 @default.
• W4367299898 cites W2472306545 @default.
• W4367299898 cites W2508058705 @default.
• W4367299898 cites W2531345178 @default.
• W4367299898 cites W2566737214 @default.
• W4367299898 cites W2584310548 @default.
• W4367299898 cites W2589099231 @default.
• W4367299898 cites W2589334089 @default.
• W4367299898 cites W2602520751 @default.
• W4367299898 cites W2607788676 @default.
• W4367299898 cites W2616605961 @default.
• W4367299898 cites W2724654878 @default.
• W4367299898 cites W2735288579 @default.
• W4367299898 cites W2749098392 @default.
• W4367299898 cites W2753774840 @default.
• W4367299898 cites W2762967811 @default.
• W4367299898 cites W2765662194 @default.
• W4367299898 cites W2778544629 @default.
• W4367299898 cites W2781525129 @default.
• W4367299898 cites W2793022348 @default.
• W4367299898 cites W2890895986 @default.
• W4367299898 cites W2901666999 @default.

• next