Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367300172> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4367300172 abstract "The high morbidity and mortality rate of the pulmonary arterial hypertension (PAH) is partially explained by the metabolic deregulation associated with the disease. The present study identified statistically significant increase of the glucose transporter solute carrier family 2 (Slc2a1), beta nerve growth factor (Ngf), and nuclear factor erythroid derived 2, like 2 (Nfe2l2) on three standard PAH rat models and their healthy counterpart. PAH was induced by subjecting the animals to hypoxia (HO group) or by injecting them with monocrotaline in either normal (CM) or hypoxic (HM) atmospheric conditions. The Western blot and double immunofluorescent experiments were complemented with the gene expression profiling of the animal lungs analyzed from the perspective of the Genomic Fabric Paradigm. We found substantial remodeling of the genomic fabrics of the citrate cycle, pyruvate metabolism, glycolysis/gluconeogenesis and fructose and manose pathways. According to the novel transcriptomic distance criterion, the most comprehensive measure of the transcriptomic alteration, glycolysis/gluconeogenesis was the most affected functional pathway in all three PAH models. PAH decoupled the coordinated expression of many metabolic genes and replaced Pmm2 with Pmm1 in the center of the fructose and mannose metabolism. Our data show that metabolic dysregulation is a major pathogenic factor of the PAH." @default.
- W4367300172 created "2023-04-29" @default.
- W4367300172 creator A5008709494 @default.
- W4367300172 creator A5051420597 @default.
- W4367300172 creator A5077549848 @default.
- W4367300172 creator A5083455648 @default.
- W4367300172 date "2023-04-28" @default.
- W4367300172 modified "2023-09-25" @default.
- W4367300172 title "Metabolic Deregulation in Pulmonary Hypertension" @default.
- W4367300172 doi "https://doi.org/10.20944/preprints202304.1105.v1" @default.
- W4367300172 hasPublicationYear "2023" @default.
- W4367300172 type Work @default.
- W4367300172 citedByCount "0" @default.
- W4367300172 crossrefType "posted-content" @default.
- W4367300172 hasAuthorship W4367300172A5008709494 @default.
- W4367300172 hasAuthorship W4367300172A5051420597 @default.
- W4367300172 hasAuthorship W4367300172A5077549848 @default.
- W4367300172 hasAuthorship W4367300172A5083455648 @default.
- W4367300172 hasBestOaLocation W43673001721 @default.
- W4367300172 hasConcept C104317684 @default.
- W4367300172 hasConcept C126322002 @default.
- W4367300172 hasConcept C134018914 @default.
- W4367300172 hasConcept C150194340 @default.
- W4367300172 hasConcept C161573976 @default.
- W4367300172 hasConcept C162317418 @default.
- W4367300172 hasConcept C165135838 @default.
- W4367300172 hasConcept C17093226 @default.
- W4367300172 hasConcept C178790620 @default.
- W4367300172 hasConcept C185592680 @default.
- W4367300172 hasConcept C192989942 @default.
- W4367300172 hasConcept C20251656 @default.
- W4367300172 hasConcept C20904676 @default.
- W4367300172 hasConcept C2776970464 @default.
- W4367300172 hasConcept C2779306644 @default.
- W4367300172 hasConcept C540031477 @default.
- W4367300172 hasConcept C55493867 @default.
- W4367300172 hasConcept C62231903 @default.
- W4367300172 hasConcept C71924100 @default.
- W4367300172 hasConcept C7836513 @default.
- W4367300172 hasConcept C86803240 @default.
- W4367300172 hasConceptScore W4367300172C104317684 @default.
- W4367300172 hasConceptScore W4367300172C126322002 @default.
- W4367300172 hasConceptScore W4367300172C134018914 @default.
- W4367300172 hasConceptScore W4367300172C150194340 @default.
- W4367300172 hasConceptScore W4367300172C161573976 @default.
- W4367300172 hasConceptScore W4367300172C162317418 @default.
- W4367300172 hasConceptScore W4367300172C165135838 @default.
- W4367300172 hasConceptScore W4367300172C17093226 @default.
- W4367300172 hasConceptScore W4367300172C178790620 @default.
- W4367300172 hasConceptScore W4367300172C185592680 @default.
- W4367300172 hasConceptScore W4367300172C192989942 @default.
- W4367300172 hasConceptScore W4367300172C20251656 @default.
- W4367300172 hasConceptScore W4367300172C20904676 @default.
- W4367300172 hasConceptScore W4367300172C2776970464 @default.
- W4367300172 hasConceptScore W4367300172C2779306644 @default.
- W4367300172 hasConceptScore W4367300172C540031477 @default.
- W4367300172 hasConceptScore W4367300172C55493867 @default.
- W4367300172 hasConceptScore W4367300172C62231903 @default.
- W4367300172 hasConceptScore W4367300172C71924100 @default.
- W4367300172 hasConceptScore W4367300172C7836513 @default.
- W4367300172 hasConceptScore W4367300172C86803240 @default.
- W4367300172 hasLocation W43673001721 @default.
- W4367300172 hasOpenAccess W4367300172 @default.
- W4367300172 hasPrimaryLocation W43673001721 @default.
- W4367300172 hasRelatedWork W1873871307 @default.
- W4367300172 hasRelatedWork W2046344380 @default.
- W4367300172 hasRelatedWork W2133707772 @default.
- W4367300172 hasRelatedWork W2475714415 @default.
- W4367300172 hasRelatedWork W3015139478 @default.
- W4367300172 hasRelatedWork W3122022461 @default.
- W4367300172 hasRelatedWork W3127871318 @default.
- W4367300172 hasRelatedWork W3204388171 @default.
- W4367300172 hasRelatedWork W4297807345 @default.
- W4367300172 hasRelatedWork W4328101219 @default.
- W4367300172 isParatext "false" @default.
- W4367300172 isRetracted "false" @default.
- W4367300172 workType "article" @default.