FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367300312> ?p ?o ?g. }

• W4367300312 abstract "Abstract African trypanosomes replicate within infected mammals where they are constantly exposed to the molecules of the complement system. This system centres around complement factor C3, which is present in a soluble form in serum but can become covalently deposited onto the surfaces of pathogens after proteolytic cleavage to C3b. Membrane-associated C3b triggers different complement-mediated effectors which promote pathogen clearance, including complement receptor-mediated stimulation of immune cells or recruitment of components of the pore-forming membrane attack complex. To counter complement-mediated clearance, African trypanosomes have a cell surface receptor, ISG65, which binds to C3b and which decreases the rate of trypanosome clearance in an infection model. However, the mechanism by which ISG65 reduces C3b function had not been determined. We reveal through cryogenic electron microscopy that ISG65 has two distinct binding sites for C3b, only one of which is available in C3, ensuring that ISG65 preferentially binds to active C3b. We show that ISG65 does not block the formation of C3b or the function of the C3 convertase which catalyses the surface deposition of C3b. However, we show that ISG65 forms a specific conjugate with C3b, perhaps acting as a decoy. ISG65 also occludes the binding sites for complement receptors 2 and 3, which will disrupt recruitment of immune cells, including B cells, phagocytes and granulocytes. This suggests that ISG65 protects trypanosomes by combining multiple approaches to dampen the complement cascade." @default.
• W4367300312 created "2023-04-29" @default.
• W4367300312 creator A5014342835 @default.
• W4367300312 creator A5035509700 @default.
• W4367300312 creator A5059482371 @default.
• W4367300312 date "2023-04-27" @default.
• W4367300312 modified "2023-09-28" @default.
• W4367300312 title "Molecular mechanism of complement inhibition by the trypanosome receptor ISG65" @default.
• W4367300312 cites W1538755475 @default.
• W4367300312 cites W1570116363 @default.
• W4367300312 cites W1884715737 @default.
• W4367300312 cites W1963924977 @default.
• W4367300312 cites W1990643927 @default.
• W4367300312 cites W1992665403 @default.
• W4367300312 cites W2010717419 @default.
• W4367300312 cites W2025764746 @default.
• W4367300312 cites W2042777883 @default.
• W4367300312 cites W2054891189 @default.
• W4367300312 cites W2066663106 @default.
• W4367300312 cites W2075176915 @default.
• W4367300312 cites W2081151783 @default.
• W4367300312 cites W2084969272 @default.
• W4367300312 cites W2091933198 @default.
• W4367300312 cites W2104555813 @default.
• W4367300312 cites W2119211468 @default.
• W4367300312 cites W2124026197 @default.
• W4367300312 cites W2137578797 @default.
• W4367300312 cites W2141596893 @default.
• W4367300312 cites W2144278357 @default.
• W4367300312 cites W2145825761 @default.
• W4367300312 cites W2149923399 @default.
• W4367300312 cites W2150321849 @default.
• W4367300312 cites W2162509748 @default.
• W4367300312 cites W2167279371 @default.
• W4367300312 cites W2169466938 @default.
• W4367300312 cites W2180229411 @default.
• W4367300312 cites W2200760358 @default.
• W4367300312 cites W2305931865 @default.
• W4367300312 cites W2510934692 @default.
• W4367300312 cites W2545964391 @default.
• W4367300312 cites W2587625522 @default.
• W4367300312 cites W2765322245 @default.
• W4367300312 cites W2770867713 @default.
• W4367300312 cites W2801376357 @default.
• W4367300312 cites W2887001097 @default.
• W4367300312 cites W2899714098 @default.
• W4367300312 cites W3011865457 @default.
• W4367300312 cites W3083406432 @default.
• W4367300312 cites W3091635362 @default.
• W4367300312 cites W3103292928 @default.
• W4367300312 cites W3177828909 @default.
• W4367300312 cites W4293503604 @default.
• W4367300312 cites W4321078922 @default.
• W4367300312 doi "https://doi.org/10.1101/2023.04.27.538609" @default.
• W4367300312 hasPublicationYear "2023" @default.
• W4367300312 type Work @default.
• W4367300312 citedByCount "0" @default.
• W4367300312 crossrefType "posted-content" @default.
• W4367300312 hasAuthorship W4367300312A5014342835 @default.
• W4367300312 hasAuthorship W4367300312A5035509700 @default.
• W4367300312 hasAuthorship W4367300312A5059482371 @default.
• W4367300312 hasBestOaLocation W43673003121 @default.
• W4367300312 hasConcept C111684460 @default.
• W4367300312 hasConcept C12554922 @default.
• W4367300312 hasConcept C14356644 @default.
• W4367300312 hasConcept C159654299 @default.
• W4367300312 hasConcept C170493617 @default.
• W4367300312 hasConcept C175773311 @default.
• W4367300312 hasConcept C185592680 @default.
• W4367300312 hasConcept C189446657 @default.
• W4367300312 hasConcept C203014093 @default.
• W4367300312 hasConcept C2778212101 @default.
• W4367300312 hasConcept C34343649 @default.
• W4367300312 hasConcept C55493867 @default.
• W4367300312 hasConcept C86803240 @default.
• W4367300312 hasConcept C8891405 @default.
• W4367300312 hasConcept C9478725 @default.
• W4367300312 hasConcept C95444343 @default.
• W4367300312 hasConceptScore W4367300312C111684460 @default.
• W4367300312 hasConceptScore W4367300312C12554922 @default.
• W4367300312 hasConceptScore W4367300312C14356644 @default.
• W4367300312 hasConceptScore W4367300312C159654299 @default.
• W4367300312 hasConceptScore W4367300312C170493617 @default.
• W4367300312 hasConceptScore W4367300312C175773311 @default.
• W4367300312 hasConceptScore W4367300312C185592680 @default.
• W4367300312 hasConceptScore W4367300312C189446657 @default.
• W4367300312 hasConceptScore W4367300312C203014093 @default.
• W4367300312 hasConceptScore W4367300312C2778212101 @default.
• W4367300312 hasConceptScore W4367300312C34343649 @default.
• W4367300312 hasConceptScore W4367300312C55493867 @default.
• W4367300312 hasConceptScore W4367300312C86803240 @default.
• W4367300312 hasConceptScore W4367300312C8891405 @default.
• W4367300312 hasConceptScore W4367300312C9478725 @default.
• W4367300312 hasConceptScore W4367300312C95444343 @default.
• W4367300312 hasLocation W43673003121 @default.
• W4367300312 hasOpenAccess W4367300312 @default.
• W4367300312 hasPrimaryLocation W43673003121 @default.
• W4367300312 hasRelatedWork W2038350920 @default.
• W4367300312 hasRelatedWork W2054891189 @default.
• W4367300312 hasRelatedWork W2158163482 @default.

• next